The invention relates to a method for catalytic conversion preparation of a hexahydric alcohol from jerusalem artichoke as a raw material. The method is characterized in that a raw material of natural biomass jerusalem artichoke (mainly comprising fructose-based polysaccharide carbohydrates) undergoes a reaction at a temperature above 20 DEG C under hydrogen pressure of 1 to 13MPa in the presence of water as a solvent and a catalyst or a mixed catalyst for at least 5 minutes, wherein the catalyst comprises acidic carriers and one or more of transition metals of iron, cobalt, nickel, copper, ruthenium, rhodium, palladium, iridium and platinum loaded on the acidic carriers; and the mixed catalyst comprises solid acids and a metal hydrogenation catalyst comprising carriers and one or more of transition metals of iron, cobalt, nickel, copper, ruthenium, rhodium, palladium, iridium and platinum loaded on the carriers. Through one-step catalytic conversion, high-efficiency, high-selectivity and high-yield preparation of a hexahydric alcohol such as mannitol and sorbitol from jerusalem artichoke as a raw material is realized.