Promoter pCALM2 and application thereof

A promoter, paav-pcalm2- technology, applied to the promoter pCALM2 and its application fields, can solve the problems such as the inability to meet the specificity requirements, and achieve the effects of high labeling efficiency, improved expression specificity, and wide application prospects.
CN112725342APending Publication Date: 2021-04-30SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Publication Date
2021-04-30

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Abstract

The invention discloses a promoter pCALM2 and an application thereof. The nucleotide sequence of the promoter pCALM2 is as shown in SEQ ID NO: 1. The promoter pCALM2 can be applied to recombinant adeno-associated viruses, so that exogenous genes can be efficiently expressed in the forebrain, and the promoter pCALM2 has a wide application prospect in the fields of neural circuit tracing and gene therapy.
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Description

technical field

[0001] The invention belongs to the technical field of neural engineering, in particular to a promoter pCALM2 and its application. Background technique

[0002] The forebrain belongs to the highest part of the brain and is the most complex and important nerve center in mammals. It is mainly composed of two parts: the telencephalon and the diencephalon. The telencephalon mainly includes the entire cerebral cortex, limbic system and basal ganglia, and the diencephalon mainly includes the thalamus and hypothalamus. It is involved in the regulation of many important physiological functions including movement, sensation, perception, autonomic nervous system, endocrine, feeding, learning, memory, cognition and so on. The analysis of forebrain neural circuits and their functions can help us better understand the high-level functions of the brain. The study of the forebrain can also help us better understand the pathogenesis of neurological diseases, and then find...

Claims

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