Biological factor coating stent and preparation method thereof

Abstract

The invention belongs to the technical field of medical instruments, and discloses a biological factor coating stent and a preparation method thereof. The biological factor coating stent comprises a Ni-Ti stent with a PDA coating, a DA stent with a heparin sodium coating, a DA-Hep stent with a VEGF coating, a DA-Hep stent with an anti-CD 34 antibody coating, a stent without heparin, and a stent simultaneously loaded with PDA, biological factors and heparin. Self-polymerization of dopamine DA is utilized to form polydopamine PDA, and an irreversible organic complex is formed on the metal surface and metal, so that the PDA is used as a connecting stent and a biological factor medium coating; and after a polydopamine PDA coating is constructed on the surface of the stent, heparin Hep, vascular endothelial growth factor VEGF and an anti-CD 34 antibody are sequentially loaded by utilizing Schiff base reaction and Michael addition, and the biological factor coating stent is obtained. Endothelial progenitor cells in blood circulation are effectively captured, and proliferation and migration of endothelial cells around the neck of an aneurysm are promoted.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a biofactor-coated stent and a preparation method thereof. Background technique [0002] At present, intracranial aneurysm rupture and bleeding is the third cause of stroke after cerebral infarction and hypertensive cerebral hemorrhage, with a prevalence of about 3%, which is a great threat to human life. However, the current stents used to treat intracranial aneurysms are all bare stents, which cannot promote the endothelialization of the aneurysm neck very well, resulting in an aneurysm recurrence rate still higher than 10% after stent treatment. Therefore, there is an urgent need for a new biological factor-coated stent and a preparation method thereof. [0003] Through the above analysis, the existing problems and defects of the prior art are: the current stents used to treat intracranial aneurysms are all bare stents, which cannot promote the endothelial...

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Problems solved by technology

[0003] Through the above analysis, the existing problems and defects of the prior art are: the current stents used to treat intracranial aneurysms are all bare stents, which cannot promote the endothelialization of the aneurysm neck very well, resulting in a higher rate of aneurysm recurrence after stent treatment. Still above 10%

[0004] The difficulty in solving the above problems and defects is: In order to solve the problem of insufficient endothelialization, the existing method is to continuously increase the metal covering rate of bare stents, such as the application of dense mesh stents, compared with the previous non-dense mesh stents. The endothelialization effect is stronger, but the endothelialization effect has not yet achieved the desired effect. In some cases, complete endothelialization has not been achieved after 1 year or even 5 years; in addition, the increasing metal coverage rate increases the risk of thrombotic events. The probability of occurrence, which also limits the application of this type of stent in some cerebral vessels, and the implantation of dense mesh stents is much more difficult than that of non-dense mesh stents

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