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Application of mt-nd6 as a new target in the diagnosis and treatment of metabolic syndrome

A MT-ND6, material technology, applied in the fields of biology and medicine, has achieved important development value, good application prospects, and easy operation

Active Publication Date: 2022-06-07
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on whether the MT-ND6 gene can regulate the occurrence of metabolic diseases such as obesity, diabetes, and hyperlipidemia.

Method used

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  • Application of mt-nd6 as a new target in the diagnosis and treatment of metabolic syndrome
  • Application of mt-nd6 as a new target in the diagnosis and treatment of metabolic syndrome
  • Application of mt-nd6 as a new target in the diagnosis and treatment of metabolic syndrome

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Experimental program
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Effect test

Embodiment 1

[0050] Methylation of MT-ND6 gene can be used as a biomarker for early clinical screening, diagnosis and prognosis of obesity, type 2 diabetes and other metabolic syndromes and their complications based on insulin resistance

[0051] like figure 1 As shown in A and C, the methylation level of the MT-ND6 gene was significantly increased in the peripheral blood leukocytes of type 2 diabetic human and in the liver of obese mice. like figure 2 As shown in C and D, linear correlation analysis showed that the methylation level of MT-ND6 gene in human peripheral blood leukocytes was positively correlated with HOMA-IR and glycosylated hemoglobin content, suggesting that methylation of MT-ND6 could serve as a biomarker of insulin resistance thing. Since insulin resistance is the pathological basis and core link of various metabolic diseases such as obesity and type 2 diabetes, the methylation of MT-ND6 gene can be used as an early clinical screening for metabolic syndrome and its co...

Embodiment 2

[0053] Methylation of MT-ND6 gene can be used as a biomarker for early clinical screening, diagnosis and prognosis of hyperlipidemia (or hyperlipidemia)

[0054] Elevated serum triglyceride levels are one of the most important features of hyperlipidemia (or hyperlipidemia), such as figure 2 As shown in B, the methylation modification level of MT-ND6 gene in human peripheral blood leukocytes is linearly positively correlated with serum triglyceride level, suggesting that the methylation of MT-ND6 gene can be used as a function of hyperlipidemia (or hyperlipidemia) Biomarkers for early clinical screening, diagnosis and prognosis.

Embodiment 3

[0056] The expression level of MT-ND6 can be used as a biomarker for early clinical screening, diagnosis and prognosis of hyperlipidemia (or hyperlipidemia), obesity, type 2 diabetes and metabolic syndrome and its complications

[0057] like figure 1 As shown in B and D, the mRNA expression level of the MT-ND6 gene was reduced in type 2 diabetic and obese mice, while as figure 2 As shown in A, the methylation of MT-ND6 gene in human peripheral blood leukocytes is linearly negatively correlated with its mRNA expression. Since the methylation level of MT-ND6 was positively correlated with serum triglyceride, HOMA-IR and glycosylated hemoglobin ( figure 2 B-D), it can be seen that the mRNA expression of MT-ND6 gene is negatively correlated with serum triglyceride, HOMA-IR and glycosylated hemoglobin levels, suggesting that the expression level of MT-ND6 (mRNA and protein levels) can be used as a function of hyperlipidemia (or hyperlipidemia). biomarkers for early clinical scr...

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Abstract

The application of MT‑ND6 as a new target in the diagnosis and treatment of metabolic syndrome, the expression of MT‑ND6 gene in the peripheral blood leukocytes of type 2 diabetic patients and the liver of obese mice was significantly reduced, and the methylation of MT‑ND6 gene Linear correlation analysis showed that the methylation level of MT‑ND6 gene was negatively correlated with its mRNA expression, and positively correlated with insulin resistance index HOMA‑IR, glycated hemoglobin content and serum triglyceride level. ‑ND6 can cause mitochondrial dysfunction, increase liver lipid droplet accumulation, and reduce insulin sensitivity at the same time, indicating that MT‑ND6 gene is closely related to the occurrence of metabolic syndrome; the present invention provides a method for clinical diagnosis and treatment of metabolic syndrome and its complications A new target with important application value.

Description

technical field [0001] The invention belongs to the fields of biology and medicine, and particularly relates to the application of MT-ND6 as a new target in the diagnosis and treatment of metabolic syndrome. Background technique [0002] Metabolic syndrome is a clinical pathological state in which various metabolic disorders such as obesity, diabetes, and dyslipidemia are abnormally aggregated. Insulin resistance is considered to be the pathological basis and core link of metabolic syndrome. With the development of social economy and changes in people's lifestyles, metabolic syndrome and the chronic non-communicable diseases caused by it have seriously threatened the health and quality of life of Chinese people. It is urgent to clarify its pathogenesis and seek more effective prevention and treatment targets. important question. [0003] Mitochondria are the key organelles that regulate glucose and lipid metabolism in cells. Under physiological conditions, mitochondrial gen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61P5/00A61P5/50A61P3/10A61P1/16A61P3/06
CPCA61K45/00A61P5/00A61P5/50A61P3/10A61P1/16A61P3/06
Inventor 刘健康曹可柳絮云龙建纲臧伟进冯智辉
Owner XI AN JIAOTONG UNIV
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