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Composition and method for inducing aging of precancerous cells

A technology for precancerous lesions and cells, which is used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Active Publication Date: 2021-07-23
SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since existing HCC chemotherapy drugs such as sorafenib, regorafenib, and cabozantinib are not targeted drugs that specifically induce HCC senescence

Method used

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  • Composition and method for inducing aging of precancerous cells
  • Composition and method for inducing aging of precancerous cells
  • Composition and method for inducing aging of precancerous cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0107] 1.1 Experimental materials

[0108] 1.1.1 Mice

[0109] In this experiment, Fah with 129S4 background was used - / - Mice, in order to ensure that there were no senescent cells in the mouse liver before the experiment, all groups used 8-week-old mice. Experimental mice were kept in SPF animal room (specific pathogen free). The mice involved in this experiment strictly followed the relevant regulations and ethical guidelines for the management of experimental animals. The feeding and animal experiments of experimental animals have been applied for ethical review and approved by the ethics committee of the research institution.

[0110] 1.1.2 Consumables and reagents

[0111] L-sodium lactate 60% solution: purchased from Sinopharm Chemical Reagent Co., Ltd., the product number is XW08675612, produced by Wokai reagent;

[0112] Palbociclib (PD-0332991): purchased from LC laboratory in the United States, the product number is P-7766;

[0113] Palbociclib (PD0332991) intr...

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Abstract

The invention provides use of a CDK inhibitor in preparation of drugs for inducing aging of precancerous cells of an object, use of the CDK inhibitor in preparation of drugs for preventing or treating a precancerous lesion or cancer of the object, and use of the CDK inhibitor in preparation of drugs for inducing immune response of the object to aged cells.

Description

technical field [0001] The present invention relates to compositions and methods for preventing and treating precancerous lesions or cancer by inducing senescence of precancerous lesions. Background technique [0002] According to CA statistics in 2018, liver cancer is the sixth most deadly cancer worldwide. As one of the malignant tumors that seriously threaten the health of our people, the incidence of liver cancer has been increasing year by year in recent years. 75%-85% of liver cancer is hepatocellular carcinoma (HCC), and it is urgent to study the mechanism of HCC occurrence and development. [0003] The occurrence of HCC is a complex pathological process, and its progress can be summarized into four stages: chronic liver disease-hepatic fibrosis-cirrhosis-HCC. 70%-80% of HCC cases have a history of liver cirrhosis, and 1 / 3 of patients with liver cirrhosis will progress to HCC. HCC is highly heterogeneous, and no dominant carcinogenic cause has yet been identified. ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K45/06A61K31/519A61P35/00
CPCA61K45/00A61K45/06A61K31/519A61P35/00
Inventor 何志颖陈文健陈苗苗卢艳丽余朝
Owner SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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