Multimodal fusion analysis method of genetic image based on white matter integrity and DNA methylation
An analysis method, methylation technology, applied in the human field, can solve problems such as in-depth mining of unfavorable multi-modal data
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[0031] In this embodiment, the DTI (diffusion tensor imaging) of 42 patients with schizophrenia ("subjects" or "patients") and 38 healthy control patients and the methylation levels of the genome-wide CpG sites of 42 patients are The research object, carries out the detailed step S of illustrating the present invention by way of example.
[0032]After collecting all subject data, firstly, step S1: perform DTI data preprocessing to ensure data consistency. Preprocessing includes: using FSL 5.0 toolkit (http: / / www.fmrib.ox.ac.uk / fsl) to correct head motion and eddy current distortion of DTI image data; using Diffusion Toolkit software (TrackVis.org ) Estimate the diffusion tensor model of each voxel by the linear least squares fitting method, and obtain the respective b0 map and FA map.
[0033] Step S2: Calculate the FA value of each voxel in the whole brain in the DTI data of all subjects (42 cases of schizophrenia patients and 38 cases of healthy controls). Specifically, it...
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