Biomarkers of neutrophil deregulation as diagnostic for gingivitis

A technology for gingivitis and gums, which is applied in the field of biomarkers for neutrophil imbalance as a diagnosis of gingivitis, and can solve problems such as inability to detect gingivitis

Pending Publication Date: 2021-09-10
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At first, gingivitis may not be detectable by visual inspection, but as it progresses, symptoms become more pronounced

Method used

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  • Biomarkers of neutrophil deregulation as diagnostic for gingivitis
  • Biomarkers of neutrophil deregulation as diagnostic for gingivitis
  • Biomarkers of neutrophil deregulation as diagnostic for gingivitis

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example 1

[0028] Gingivitis was successfully induced in human study subjects after 21 days of oral hygiene abstinence, as evidenced by a significant increase in gingival inflammation parameters. Chemokine analysis revealed that only macrophage inhibitory factor (MIF) was significantly increased during the induction phase of the study, whereas neutrophil chemokines MIP-1a, CXCL1, CXCL5, CXCL8, CXCL2, and CXCL6 were significantly increased after gingivitis induction Decreases initially or throughout the gingivitis induction phase. The data demonstrate that significant changes in host homeostasis occur after the onset of gingivitis, with the majority of the response being inhibition of host chemotactic factors for neutrophils.

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Abstract

Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; MIF:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.

Description

Background technique [0001] The gingiva (gum / gingiva) is the part of the soft tissue lining of the mouth that surrounds and provides a seal around the teeth. The gingival margin is the interface between the gingival sulcus epithelium and the oral epithelium. This interface exists at the most coronal point of the gingiva, also known as the coronal portion of the marginal gingiva. The gingival sulcus, also known as the sulcus, is the space surrounding the tooth between the wall of unattached gum tissue and the enamel and / or cementum. [0002] Gingivitis is inflammation of the gums as the initial stage of gum disease. The immediate cause of gingivitis is plaque - the soft, sticky, colorless film of bacteria that continually forms on the teeth and gums. Plaque, if not removed by daily brushing and flossing, produces toxins that can irritate gum tissue, causing gingivitis. In this early stage of gum disease, the damage can be reversed because the bone and connective tissues tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569G01N33/68
CPCG01N33/56955G01N2333/521G01N2333/522G01N2333/523G01N33/6863G01N33/5008
Inventor 卡米耶·泽诺比娅哈什·马亨德拉·特里维迪杨英
Owner COLGATE PALMOLIVE CO
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