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Application of semen plantaginis extract in preparation of medicine for treating myocardial hypertrophy

A technology of psyllium extract and myocardial hypertrophy, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc.

Inactive Publication Date: 2021-09-14
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no relevant report on whether the plantago seed extract has the effect of preventing and treating cardiac hypertrophy.

Method used

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  • Application of semen plantaginis extract in preparation of medicine for treating myocardial hypertrophy
  • Application of semen plantaginis extract in preparation of medicine for treating myocardial hypertrophy
  • Application of semen plantaginis extract in preparation of medicine for treating myocardial hypertrophy

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Experimental program
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Embodiment

[0030] One, the preparation of Semen Plantaginis extract of the present invention

[0031] 1) First use the ethanol aqueous solution of 70% by volume fraction to carry out reflux extraction 2 times to Fructus Plantaginis, extract 1 gram of Fructus Plantaginis with 12 milliliters of said ethanol aqueous solution, then filter and concentrate the extract collected into an extractum to obtain Semen Plantaginis Extract 1;

[0032] 2) First use 60% ethanol aqueous solution with a volume fraction to carry out reflux extraction of Semen Plantaginis once, use 6 ml of the aqueous ethanol solution for 1 gram of Semen Plantago for each extraction, then filter and concentrate the collected extract Become extractum, promptly get Semen Plantaginis extract 2;

[0033] 3) First use 80% ethanol aqueous solution with a volume fraction to carry out reflux extraction of Semen Plantaginis once, use 9 ml of the ethanol aqueous solution for each extraction of 1 gram of Semen Plantaginis, then filter...

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Abstract

The invention discloses application of a semen plantaginis extract in preparation of a medicine for treating myocardial hypertrophy. In-vivo pharmacological experiments are carried out by using an experimental animal model of isoproterenol-induced myocardial hypertrophy, and research results show that the semen plantaginis extract disclosed by the invention can be used for remarkably improving the heart function of a mouse with isoproterenol-induced myocardial hypertrophy, can be used for remarkably inhibiting myocardial morphological enlargement and high expression of an embryo gene, and the semen plantaginis extract is expected to be used for preparing medicines for preventing and treating myocardial hypertrophy or assisting in treating myocardial hypertrophy.

Description

technical field [0001] The invention relates to the use of plantago seed extract in the preparation of medicine for treating cardiac hypertrophy, and belongs to the technical field of application of traditional Chinese medicinal materials. Background technique [0002] Cardiac hypertrophy is an adaptive response of the heart to long-term overload and overactivation of neuroendocrine. The overall pathological manifestations are: increased heart volume, increased weight, concentric hypertrophy of the ventricular wall, and decreased ventricular cavity volume; the phenotype changes of the cells are mainly characterized by increased cardiomyocyte volume, increased protein content, and interstitial hyperplasia. A chronic compensatory response that is an early and important precursor to the development of chronic heart failure. [0003] Chronic heart failure (referred to as heart failure) is the end-stage manifestation of cardiovascular disease. Clinically, it is a series of compl...

Claims

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Application Information

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IPC IPC(8): A61K36/68A61P9/00A61P9/04A61P9/12A61K131/00
CPCA61K36/68A61P9/00A61P9/04A61P9/12A61K2236/333A61K2236/39
Inventor 杨莉吴晓俊范文静王峥涛
Owner SHANGHAI UNIV OF T C M
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