Pigmented glaucoma animal model building method and application thereof

A technology of animal model and establishment method, which is applied in the field of glaucoma, can solve the problems of non-pigmented glaucoma animal models, etc., and achieve the effect of high success rate, easy operation and low cost

Inactive Publication Date: 2021-10-26
三门峡市眼科医院
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Problems solved by technology

[0003] Elevated intraocular pressure is the main risk factor for the occurrence and progression of glaucoma, and animal models are one of the main means of glaucoma research. At present, there is no animal model of pigmentary glaucoma that has been stably established. Therefore, we propose a method for establishing animal models of pigmentary glaucoma and its application for further improvement

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  • Pigmented glaucoma animal model building method and application thereof

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Embodiment Construction

[0018] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0019] see figure 1 , in the embodiment of the present invention, the animal model of pigmentary glaucoma establishment method and its application, the method and its application steps are as follows:

[0020] S1: the selection of the rat model group;

[0021] S2: Carry out the making of iris pigment granule suspension;

[0022] S3: measure and record the intraocular pressure of two groups of rats;

[0023] S4 Observation of optic neuropathology in rats.

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Abstract

The invention discloses a pigmented glaucoma animal model building method and application thereof. The method and the application thereof comprise the following steps: S1, selecting a rat model group; S2, preparing an iris pigment particle suspension; S3, performing measurement and data recording on intraocular pressure of the two groups of rats; and S4, performing optic neuropathology observation on the rats. According to a glaucoma animal model established by the invention, part of characteristics of human pigmented glaucoma can be conveniently and well simulated, and the obtained intraocular hypertension lasts for a long time; the method meets the pathological characteristics of pigmented glaucoma and the requirements of low cost, medium intraocular hypertension, long duration and stability of an optic nerve protection drug pharmacodynamic experimental animal model, has the characteristics of simplicity and convenience in operation and high success rate, and meets the establishment of a pigmented glaucoma model by medical science researchers.

Description

technical field [0001] The invention relates to the technical field of glaucoma, in particular to a method for establishing an animal model of pigmented glaucoma and its application. Background technique [0002] Glaucoma is a group of diseases characterized by optic disc atrophy and depression, visual field defect and vision loss. Pathological increased intraocular pressure and optic nerve insufficiency are the primary risk factors for its onset. The tolerance of optic nerve to pressure damage Sex has also been linked to the onset and progression of glaucoma. Obstacles in any part of the aqueous humor circulation pathway can lead to pathological changes caused by elevated intraocular pressure, but some patients also present with normal intraocular pressure glaucoma. Glaucoma is one of the three major blindness diseases that cause blindness in humans, with an incidence rate of 1% in the general population and 2% after the age of 45. Clinically, glaucoma is divided into thr...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027
CPCA01K67/027A01K2227/105A01K2267/03
Inventor 党亚龙
Owner 三门峡市眼科医院
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