Intelligent analysis system and method for labial gland pathology

Abstract

The invention discloses an intelligent analysis system and method for labial gland pathology. The system comprises a labial gland tissue area determination module, a lymphocyte lesion determination module, an analysis processing module and a result display module. According to the system, by constructing a first deep neural network, the area (mm<2>) of each labial gland tissue in a labial gland digital pathological section is measured one by one, and the area of each labial gland tissue is added to obtain the total area of the labial gland tissue; meanwhile, a second deep neural network and a third deep neural network are constructed for identifying and counting the number of lymphocyte lesions aggregated by more than 50 lymphocytes to obtain the number of the lymphocyte lesions; and further whether the patient meets the gold standard for diagnosing the sicca syndrome or not is calculated, that is, the focal index is greater than or equal to 1, so as to provide diagnosis suggestions for clinicians. The system realizes intelligent analysis and evaluation of the pathology of the labial gland, can directly output a judgment result, is simple and accurate, not only solves the clinical problem that an artificial labial gland pathology report is not standard, but also can promote the process of standardized diagnosis of the sicca syndrome in China.

Description

technical field [0001] The invention belongs to the field of medical technology. More specifically, it relates to an intelligent analysis system and method for evaluating labial gland pathology. Background technique [0002] Sjögren's syndrome is a common autoimmune connective tissue disease, which is a chronic disease. It occurs frequently in middle-aged and perimenopausal women. Elevated antibody levels and the involvement of multiple organ systems outside the glands based on vasculitis. In severe cases, important organs such as the kidney, liver, and lungs may be involved, and may even lead to the death of the patient. Sjogren's syndrome is a global disease, and the annual incidence rate per 100,000 people is as high as 6.0-11.8 in Asia, followed by Europe (3.9-5.3) and North America (3.9). The prevalence rate of the Chinese population is 0.33% to 0.77%, and the estimated number of patients is not less than 4 million. Sjogren's syndrome has its unique disease involveme...

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the non-standard, inaccurate and difficult clinical operation problems in the pathological diagnosis technology of Sjogren's syndrome lip glands in the above-mentioned prior art, and provide a kind of intelligent analysis system and method for evaluating the pathology of lip glands, aiming at Let pathologists, rheumatologists and immunologists, and even patients themselves scan the stained lip gland tissue HE slices into digital pathological images, and upload them to this intelligent analysis method and system to learn the precise lip gland focal index and Compare and judge whether it meets the "gold standard" of labial gland pathology in Sjogren's syndrome, that is, the focal index of labial glands is ≥1

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