109results about How to "Conducive to clinical promotion and application" patented technology

This invention relates to a suspension chip technology for the gene test to human papillomavirus used in testing and typing 26 kinds of papillomaviruses, in which, specific probes of which are crosslinked on 26 kinds of fluorescent microspheres to be reacted with the tested specimens then reacted with the report molecules labeled by the fluorescein to test the type specific nucleic acid of the virus by a fluorescent test device, which can test 26 kinds of ordinary HPV once and increases the test efficiency greatly and overcomes the shortcoming of missing testing the potential infections in the serology and immunity test method to realize early diagnosis to HPA diseases.

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention provides a pharmaceutical composition for treating embolism and a preparation method thereof, the pharmaceutical composition comprises a hydroxyl-contained biocompatible polymer materialand a monomer containing unsaturated double bonds and anion groups, as well as a polymer generated by polymerization reaction of an optional vinyl monomer, wherein the polymerization is initiated through free radicles, and bleomycin or pingyangmycin is combined on the anion groups of the generated polymer. The preparation method combines the bleomycin or the pingyangmycin on a carrier of the polymer, thereby being capable of fully playing the dual effects of an anti-tumor antibiotic and a hardening agent owned by the bleomycin or the pingyangmycin during the embolism treatment. The anion partof the polymer can be properly combined with the bleomycin or the pingyangmycin which is rich in amino groups, thereby not only realizing the higher drug loading, but also leading the drug in an emboliaztion agent to be exchanged by cation in human body, and further realizing the slow release. In addition, the embolic carrier of the polymer has the advantages of simple prepration technology andlow cost, thereby being applicable to large-scale industrial production.

Provided are a glucagon-like peptide-1 (GLP-1) analogue monomer and dimmer, a preparation method thereof, and an application thereof. The GLP-1 analogue monomer comprises one cysteine; and the dimer is formed by two monomer molecules connected via an intermolecular disulfide bond formed by the cysteine. The GLP-1 monomer comprising cysteine has the following general formula: 7HAEX10TFTSX15VSSYLEX22X23AAKEFIX30WLX33KGRG37, wherein X10 is glycine or cysteine, X15 is aspartate or cysteine, X22 is glycine or cysteine, X23 is glutamine or cysteine, X30 is alanine or cysteine, and X33 is valine or cysteine; and only one of X10, X15, X22, X23, X30, and X33 is cysteine. The glucagon-like peptide-1 analogue dimer of the present invention has an in vivo half-life of more than 8 to 96 hours, thus facilitating clinical promotion and application.

The invention discloses a lower limb vein thrombosis prevention and treatment instrument and relates to the field of medical instruments. The lower limb vein thrombosis prevention and treatment instrument comprises a lower limb cushion and a massage device. The lower limb cushion comprises a shank cushion plate and a thigh cushion plate which are hinged. The thigh cushion plate is connected with an adjusting rod penetrating through a fixed seat. The massage device comprises a main machine and a leg sleeve. The main machine comprises a box internally provided with an electromagnetic air pump, an electromagnetic water pump, an electronic temperature adjusting device and a constant-temperature water tank. A panel of the box is provided with a time control instrument, a pressure dial gauge, a pressure adjusting valve and a temperature control instrument. The time control instrument, the pressure dial gauge and the pressure adjusting valve are connected with the electromagnetic water pump, and the temperature control instrument is connected with the electronic temperature adjusting device and the electromagnetic water pump. The leg sleeve comprises an air bag communicated with the pressure adjusting valve, and a cushion blanket arranged on the surface layer. The problems that in the prior art, the angle and the height of a lower limb cushion cannot be adjusted, the lower limb is prone to slide down from the two sides, the popliteal space is prone to be pressed, blood circulation is affected, and the cold-proof and heat preservation effect on the affected limb is poor and the problem that the inflation and deflation pressure of a pressure anti- thrombosis pump cannot be adjusted at any time are solved.

The invention relates to an automatically synthetic method of <18>F-Fallypride, and belongs to the technical field of the synthesis of the <18>F-Fallypride for dopamine D2 receptor positron(PET) developer. By adopting the PET-MF-2V-IT-I type multifunctional fluorine marking module to carry out the automatic synthesis of the <18>F-Fallypride, as well as adopting the Sep-PakC-18 to purify the <18>F-Fallypride, the invention is capable of producing D2 receptor positron(PET) developer (s)-(-)(1-allyl pyrrolidine-2-amino methyl)-5-(3-[<18>f] fluoropropyl)-2, 3-dimethoxy benzamide(<18>F-Fallypride), and surveying the biological distribution in the mouse. The radiochemical productivity of the (<18>F-Fallypride) is 40.7 percent (verified), and the synthetic period is 25mins without HPLC separation, moreover, the radiochemical purity is higher than 95 percent. After the <18>F-Fallypride in injected, the radioactivity is mainly distributed in the liver. The injection of the striaturn in the brain is the highest, and the cleanness is slow. The automatic synthesis of the <18>F-Fallypride is rapid and efficient. Besides, the <18>F-Fallypride is a fine dopamine D2 receptor positron(PET) developer.

The invention provides a medicine composite used for embolotherapy and acesodyne and a preparation method thereof. The medicine composite comprises a biocompatibility macromolecular compound containing hydroxy, a monomer containing unsaturated double bond and anion group, a polymer, and local anesthetic containing amino group, wherein the polymer is generated through a polymerization reaction of an optional vinyl monomer and the polymerization reaction is initiated by free radicals, and the local anesthetic is combined to an anion group of the generated polymer. In the invention, lidocaine hydrochloride is combined to a polymer carrier; which can give full play to the acesodyne effect of the local anesthetic in the embolotherapy; the anion part of the polymer can properly combine with the local anesthetic containing the amino group, which can both realize higher medicine loading capacity and enable the medicine in an emboliaztion agent to be exchanged by cations in vivo and then slowly released. Moreover, the polymer emboliaztion carrier has simple technology, low cost, and suitability for large scale industrial production.

The invention provides an embolization polymer. The embolization polymer is prepared by performing polymerization reaction initiated by free radicals on micromolecule monomer containing unsaturated double bonds, monomer containing unsaturated double bonds and an optional cross-linking agent; the cross-linking agent is polyfunctionality water-soluble acrylate or acrylamide. The embolization polymeris an ion exchange microsphere carrier and has higher deformation ability and higher drug trapping efficiency and drug loading capacity; meanwhile, a slow release effect is better. The invention further provides a novel blood vessel embolization chemotherapy composite. The embolization chemotherapy composite disclosed by the invention can jointly deliver an embolization agent and chemotherapy drug to a target blood vessel part through a catheter, so that a curative effect of the chemotherapy drug is fully played, peripheral normal tissues are prevented from being damaged, and disease relapsing is reduced.

The invention discloses a novel sputasol for isolated culture of Legionnella, which can be used for sputamentum digestion in isolated culture of Legionnella and can be also used as a digestive juice for conventional bacterial culture of clinical sputamentum. The sputasol comprises the following components: 2.0g of dithiothreitol (DTT), 0.894g of ethylene diamine tetraacetic acid (EDTA), 0.4g of potassium chloride, 3.6g of dipotassium hydrogen phosphate, 0.4g of potassium dihydrogen phosphate and 100g of water. By using the DTT, the sputasol breaks disulfide bonds in mucoproteins, thereby degrading the mucoproteins and digesting the sputamentum. By adding the EDTA into the sputasol, the EDTA can react with alkali metal, rare earth elements, transition metal and the like to form stable water-soluble complexes, thereby avoiding the poison of heavy metallic salts on the Legionnella. A buffer system comprises KCl, K2HPO4, KH2PO4 and other potassium salts and avoids the inhibiting effect of Na<+> ions on the Legionnella, thereby improving the positive rate in isolated culture of the Legionnella.

The invention provides a mobile phone capable of realizing multi-lead ECG (electrocardiogram) examination and ECG monitoring. Part of a body of the mobile phone is taken as a negative electrode (1), and part of the bottom is a positive electrode (2). The right hand holds the mobile phone, the bottom electrode is contacted with a detection point to collect ECG data, and a complete lead system-righthand lead ECG is formed; a complete conventional standard lead ECG can be derived by calculation. Three limb leads of three lead types are connected to the corresponding positions, the mobile phone is held by the right hand, the bottom electrode is placed at chest lead detection points respectively, and a standard lead ECG can be collected by only three leads with the method. The ECG data collection required by one complete lead system is completed by the mobile phone with only two electrodes for the first time, and the data can be directly analyzed or converted into the standard lead ECG foranalysis. The leads can be adopted for ECG examination, ECG monitoring or remote ECG monitoring. The demand of a patient for ECG and ECG monitoring anytime and anywhere is met.

The invention belongs to the technical field of medicines. The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for preventing and treating COVID-19 (diseases caused by novel coronaviruses) and a preparation method thereof. The pharmaceutical composition comprises active ingredients of mycobacterium vaccae for injection and salbutamol sulfate, and the weight ratio of the mycobacterium vaccae for injection to the salbutamol sulfate is 1: (50-200). The medicine prepared from the medicine composition can adopt an aerosol inhalation treatment mode, and through short-term aerosol inhalation, the compliance of a patient can be improved by providing the medicine with a specific purpose for the patient, so that the patient can take the medicine conveniently, and the medical cost is reduced. The pharmaceutical composition for preventing and treating COVID-19 disclosed by the invention has the advantages that the COVID-19 can be effectively prevented and treated; severe or critical symptoms of patients are relieved, nucleic acid negative conversion time is shortened by about 4 days averagely, treatment time is correspondingly shortened, other respiratory virus infections can be prevented and treated nonspecifically, and a new way and scheme are provided for clinical prevention and treatment of COVID-19 and respiratory virus infections.

The invention provides a method for simultaneously determining free thyroid hormones T3, T4, rT3 and cortisol in saliva, which comprises the following steps of performing ultrafiltration and centrifugation, selecting a filter membrane with a proper molecular weight cutoff limit range, removing protein and combined thyroid hormones and cortisol in the saliva, adding anti-adsorption reagents such as methanol according to a proper proportion, and overcoming the problem of serious adsorption in the detection process of free T3, rT3, T4 and cortisol in saliva. The four free thyroid hormones T3, rT3 and T4 and cortisol in saliva can be simultaneously and accurately detected at one time by utilizing a high performance liquid chromatography-tandem mass spectrometry analysis technology. The method has the advantages of high throughput, simplicity and convenience in operation, high treatment efficiency, low consumable cost, high accuracy and high sensitivity, and is convenient for clinical popularization and application.

The present invention relates to a Chinese medicine preparation for curing woman menopausal syndrome. Said Chinese medicine preparation is made by using the Chinese meterials of curculigo root and epimedium as main material and other four auxiliary materials. Said invention features good therapeutic effect and small side effect. Said invention also provides its preparation method.

A preparing method of a human DCCIK immunocompetent cell is disclosed. The method includes steps of: (1) separating a mononuclear cell from human peripheral blood; (2) inoculating the mononuclear cell to a culture medium suitable for lymphocyte culturing, adding IFN[gamma], IL-2, an anti-CD3 monoclonal antibody, GM-CSF and IL-4, and culturing for 3-5 days; (3) adding TNF[alpha], and continuously culturing for 1-2 days; and (4) adding IL-2, and continuously culturing for 7-10 days to obtain the DCCIK cell. A composition of various cytokines and stimulating factors is added directly into the mononuclear cell so that the DC cell and lymphocyte induce at the same time and mutually stimulate maturity, thus simplifying operation steps, reducing experiment consumable items and shortening cell culturing time. In addition, normalized experiment process technology can be easily mastered, thus facilitating clinic popularization and application.

The invention provides a Gelan Xinning soft capsule for treating coronary disease and angina and a preparation method of the Gelan Xinning soft capsule. The medicine comprises the following raw materials in parts by weight or is composed of the following raw materials in parts by weight: 4 to 60 parts of radix puerariae general flavones, 1 to 30 parts of fructus crataegi extract, 0.4 to 10 parts of gynostemma pentaphylla general flavones, 5 to 100 parts of soybean oil or salad oil, 0.1 to 3 parts of beewax, 0.4 to 10 parts of hydrogenated palm oil, 0.2 to 5 parts of soyabean lecithin, 0.01 to 0.5 parts of dimeticone, 8 to 150 parts of gelatin, 3 to 80 parts of glycerol, 8 to 150 parts of purified water and 0.01 to 0.8 parts of ethylparaben. The preparation method of the medicine provided by the invention is simple, the processing cost is low, the efficacy is remarkable and the Gelan Xinning soft capsule is free from any toxic and side effects.

The invention relates to a method for quantitatively detecting TRAb plate-type fluorescent enzyme immunity and an application thereof. The method is characterized in that recombination human thyroxin stimulating hormone receptor (hTSHR) extracellular domain amino terminal proteins is taken as antigen to coat a perforated plate and then is sealed by PBST containing 1-5% of BSA; anti-hTSHR first antibody or standard substance, enzyme-labeled second antibody, fluorescent substrate and stopping solution are sequentially added by utilizing the perforated plate as a carrier; and finally fluorescence intensity is measured on a fluorescence illuminant analyzer. The clinical detection of TRAb which mainly comprises TSAb in patient serum has great significance on pathogenic diagnosis, curative effect observation and drug withdrawal occasion determination of GD hyperthyroidism. The invention performs the fluorescence enzyme immunoassay by utilizing a multi-hole site plastic plate as a solid carrier, has easy sheet material source, low cost and easy promotion, and the method is distinctive, sensitive, accurate and stable, thereby being suitable for clinical requirement and promotion.

The invention discloses a fixed protection device for a PD (peritoneal dialysis) external short pipe. The device comprises a fixing cover, a yielding groove, a fixing plate, a yielding hole, a first spring, a pressing plate, a snap ring, an ultraviolet germicidal lamp, a base, an observation cover plate, a sliding rod, a sliding block, a second spring and a shading plate. The fixed protection device for the PD external short pipe has ingenious structure and powerful functions, the external short pipe and a port of a dialysate bag can be connected and fixed more firmly during external connection for change operation of a dialysate by protective wearing type design, and the problem of pipe falling off and separation is greatly solved; besides, the device can be carried, operated and used conveniently, clinical practicality is expanded; moreover, purposes of sterilization and disinfection can be achieved by the cooperation effect of an internal sterilization mechanism, breeding of bacteria is effectively reduced, the effects of cleaning, sanitation and infection prevention are achieved, and finally, the purpose of clinical popularization and application is well achieved.

The invention discloses a percutaneous lumbar aperture mirror puncture assisted locator. The percutaneous lumbar aperture mirror puncture assisted locator comprises a base, a crossbar, a slider, and apuncture positioning assembly, the puncture positioning assembly comprises: a horizontal angle instrument, a vertical angle instrument and a puncture sleeve, a first curved slide rail and a second curved slide rail are respectively formed on the horizontal angle instrument and the vertical angle instrument, the vertical angle instrument slides in the first curved slide rail, and the puncture sleeve slides in the second curved slide rail. The puncture-assisted locator of the invention can realize accurate puncture of the intervertebral foramen conveniently and quickly at low cost, avoids blindness of puncture and reduces the risk of neurovascular injury. The puncture-assisted locator is easy to learn and use, the weight is light, and the components can be separately disassembled and placedin a fast-moving box of the apparatus, which has a good promotion and application prospect in the industry. The puncture-assisted locator enables more low-grade specialists to familiarize themselveswith the use of a percutaneous puncture technique and shortens the learning cycle, which is conducive to the clinical application of the procedure.

The invention relates to a Chinese medicinal composition for treating cold and a preparation method thereof. The composition comprises the following raw materials in part by weight: 150 to 200 parts of baical skullcap root, 150 to 200 parts of weeping forsythia, 90 to 120 parts of heterophylly falsestarwort root, 90 to 120 parts of fineleaf schizonepeta herb, 50 to 80 parts of cablin potchouli herb, 90 to 120 parts of honeysuckle flower, 90 to 120 parts of indigowoad root, 50 to 80 parts of swordlike atractylodes rhizome, 50 to 80 parts of kudzuvine root and 30 to 60 parts of liquoric root. The composition is prepared by cleaning and wetting medicinal materials, filtering, concentrating, uniformly mixing, loading into capsules, sterilizing, and the like. The composition is abundant in prescription medicine source, short in treatment course and low in medicine price, has an obvious curative effect, is convenient to take and easily accepted by patients, and has a definite curative effect and is safely taken and controllable in quality after being massively and clinically used for years; the preparation process is simple; and the composition is prepared into the capsules, so the composition is convenient to take compared with the traditional decoction and pills, and is easy to clinically popularize and apply.

The invention provides compound cortex phellodendri liquid coating mouthwash gel. The mouthwash gel comprises, by weight, 0.1 to 10% of chitosan, 0.1 to 2% of carbomer, 2 to 40% of glycerin, 0.05 to 0.1% of ethylparaben, 0.5 to 4.0% of triethanolamine, 2 to 10% of propylene glycol, 0.5 to 5% of Tween-80 and the balance of compound cortex phellodendri medical extract. The compound cortex phellodendri extract is prepared from a mixed liquid of medical plant extract and centipede enzymatic hydrolysate through cryoconcentration. According to the physical and chemical properties of effective components in the compound cortex phellodendri liquid and dosage forms, the gel matrix is preliminarily determined. The mouthwash gel can inhibit a variety of bacteria, forms a cured film on the ulcer surface to effectively isolate pathogens, has effects of diminishing inflammation, easing pain and promoting healing and can produce good curative effects on dental ulcer caused by radiotherapy and chemotherapy.

The invention discloses a multifunctional medical treatment bed which comprises a bed frame and a bed body. The multifunctional medical treatment bed is characterized in that the bed body comprises a head and waist supporting structure, a waist and hip supporting structure and a leg supporting structure; the heat and waist supporting structure can be horizontally or obliquely arranged along the bed body; the waist and hip supporting structure consists of multiple supporting cushions capable of ascending and descending, and the lower part of each supporting cushion is provided with a support structure connected with the bed frame; the leg support structure is internally provided with pressure sore prevention piece; the pressure sore prevention piece can slide in the bed body so as to form a convex arc shape. The multifunctional medical treatment bed is scientific and simple in structure; by virtue of arranging four supporting cushions which are capable of ascending and descending and can move horizontally, a multipoint support effect for the waist and hip and an effect of facilitating defecation can be realized; compared with an existing single lifting device, the multifunctional medical treatment bed has the characteristic of applicability to multiple crowds.

The invention discloses a medicinal Chinese medicine for curing regenerative obstructive anaemia and its preparing technique, prepared in proportion of red ginseng tails, Radix astragali, Radix rehmanniae preparata, dodder seed, alter slice, moxibustion tortoise plastron, medlar, Malaytea Scurfpea Fruit, Prepared Common Monkshood Daughter Root, and cinnamon. And the preparing technique: decocting the above ten raw materials twice and combining the two filtrates; then concentrating, alcohol-depositing, cooling to room temperature and making into cream; drying the cream and then making powder spraying and filling into capsules; or adding dextrin or starch to the cream to make into soft material, and finally screening and drying the soft material to make into electuary or tablets. It can not only regulate mediation disorder of human immunity, stimulate the hemopoiesis recovery of human marrow, and have remarkable curative effect on the regenerative obstructive anaemia but also has considerably good curative effect on other refractory anaemias, as well as the symptoms caused by various reasons, such as marrow inhibition, blood cell reduction, etc. And it almost has no toxicity and side effect, safe and reliable, low-cost.

A diaphysis drilling protector for ensuring correct drilling on diaphysis and protecting periost and soft tissue has a guiding sleeve pipe with a drilling hole, and a C-shaped diaphysis supporting handle with a front end used as the barrier plate of drill bit.

The invention relates to a gamithromycin emulsion. Each 100g of the gamithromycin emulsion comprises the following components by weight of 0.01 to 5.0 g of gamithromycin, 0.1 to 16.0 g of lysimachia christinae hance oil, 0.1 to 5.0 g of ethyl linoleate, 8.0 to 30.0 g of sucrose fatty acid ester, 10.0 to 20.0 g of polyoxyethylene ether (60) hydrogenated castor oil, 5.0 to 10.0 g of 1, 2-propylene glycol and the balance of deionized water. Meanwhile, the invention further discloses a preparation method, the process operability is high, and production conversion is facilitated. The emulsion disclosed by the invention is in an oil-water mutual wrapping type, the prepared product can be infinitely diluted with water and can also be infinitely diluted with oil, after being diluted with water, the emulsion can meet the drinking water administration requirement and is convenient to use, and after being diluted with oil, the emulsion can be prepared into a slow-release emulsion, so that a long-acting antibacterial effect is achieved, and the administration frequency is reduced. The emulsion disclosed by the invention can be used for preventing and treating ileitis diseases caused by pig Lawsonia intracellularis infection, has an effect obviously better than that of the prior art, and has a wide market application prospect.

The invention discloses a preparation method of a compound traditional Chinese medicine nasal spray. The method involves with the following raw materials in parts by weight: 2-4 parts of honeysuckle stem, 1-2 parts of smilax glabra, 1-2 parts of Scutellaria baicalensis, 1-2 parts of sophora flavescens, 1-2 parts of mint, 1-2 parts of agastache rugosus, 1-2 parts of honeysuckle flower, 1-2 parts of chrysanthemum indicum, 1-2 parts of magnolia flower and 1-2 parts of herba houttuyniae. The preparation method comprises the following steps: mixing the raw materials and decocting with water, distilling and collecting volatile ingredients; stopping distilling, continuing decocting with water and concentrating, filtering and removing residues, refrigerating the liquid medicine and precipitating through night to obtain a clarified solution, and then mixing the clarified solution with the distillate, adding sodium benzoate, and finally adjusting the pH value, thereby obtaining the finished product. The compound traditional Chinese medicine nasal spray is capable of treating the diseases such as acute and chronic sinusitis and rhinitis, adenoidal hypertrophy of children and secretory otitis media, behaves well in the advantage of the traditional Chinese medicine of treating both symptoms and root causes, and is wide in application range and free from toxic and side effects; the compound traditional Chinese medicine nasal spray does not harm the previous physiological functions and structures of the turbinates, and further has the characteristics of simpleness and convenience in operation, relatively short course of treatment, satisfying effect, high cure rate and the like.

The invention discloses a sucking training instrument for a neonate and a training method of the sucking training instrument for the neonate. The sucking training instrument for the neonate comprises a pressure measurement silicone tube, a pressure sensor, a sensor signal amplifying circuit, a microprocessor and a touch display screen, wherein one end of the pressure measurement silicone tube is a sucking end, the other end of the pressure measurement silicone tube is connected with a T-shaped tube, the pressure sensor is arranged at one end of the T-shaped tube, the other end of the T-shaped tube is connected with a milk storage device, and a milk valve is arranged at the end, connected with the milk storage device, of the T-shaped pipe; the pressure sensor is connected with the microprocessor through the sensor signal amplifying circuit, and the microprocessor is connected with the touch display screen and the milk valve and is used for controlling opening and closing of the milk valve. According to the sucking training instrument for the neonate and the training method of the sucking training instrument for the neonate, the initial sucking negative pressure of the neonate is obtained through a pressure measurement device, then parameters of the neonate are input through the touch screen, a target negative pressure for training is given by a system, the microprocessor controls the milk valve to be opened when the sucking negative pressure of the neonate reaches a predetermined value, and then the neonate can suck milk in the milk storage device. The pressure value can be increased step by step in the future, and thus the purposes of increasing sucking negative pressure of the neonate and fully stimulating milk secretion are achieved.

The invention provides an anti-acne drug and a preparation method thereof. The anti-acne drug is characterized by being prepared from the following medicines: 160g of dandelion, 240g of salvia miltiorrhiza, 240g of scutellaria baicalensis, 48g of coptis chinensis, 150g of eclipta alba, 48g of rheum officinale, 160g of glossy privet fruit, 160g of radix angelicae, 240g of coix lachrymal, 160g of radices trichosanthis, 48g of liquorice, 320g of oldenlandia diffusa, 240g of spina gleditsiae, 48g of radix bupleuri, 120g of cotex dictamni, and 120g of the root bark of white mulberry. The drug is mainly used for clearing heat-toxin and eliminating dampness, activating blood circulation, eliminating carbuncle and expelling pus, can comprehensively condition each viscera and clearly distinguish deficiency and excess, and has the effects of clearing heat to eliminate acne, removing dampness to eliminate acne, expelling carbuncle to eliminate acne, and activating blood circulation to eliminate acne.

The invention discloses an Lf-HA-DOX macromolecule prodrug compound, a constructing method thereof and an application of the Lf-HA-DOX macromolecule prodrug compound to treating glioma. According to the Lf-HA-DOX macromolecule prodrug compound, lactoferrin (Lf) serves as ligand for targeting modification, Doxorubicin (DOX) serves as a therapeutic drug, hyaluronic acid (HA) serves as a carrier skeleton, tumor targeting of the HA is used, and the double-targeting macromolecule prodrug compound is obtained. The Lf-HA-DOX macromolecule prodrug compound can penetrate through blood brain barriers, and further has quite good glioma targeting; meanwhile, the effect of slowly releasing the drug can be achieved, and the Lf-HA-DOX macromolecule prodrug compound has the quite good application prospects in treatment of glioma.

The invention relates to a traditional Chinese medicine fumigation and washing agent for treating diabetic peripheral neuropathy and belongs to the technical field of traditional Chinese medicines. Crude drugs of the traditional Chinese medicine fumigation and washing agent are prepared from the following components in parts by weight: 28 to 32 parts of processed olibanum, 25 to 35 parts of processed myrrh, 15 to 22 parts of radix angelicae sinensis, 18 to 23 parts of rhizoma chuanxiong, 27 to 35 parts of caulis spatholobi, 28 to 32 parts of herba lycopodii, 28 to 32 parts of caulis impatientis, 10 to 18 parts of ramulus cinnamomi, 8 to 12 parts of black radix aconiti carmichaeli, 18 to 22 parts of rhizoma zingiberis, 12 to 18 parts of processed radix aconiti and 8 to 12 parts of herba asari. The traditional Chinese medicine fumigation and washing agent provided by the invention has the effects of invigorating qi and promoting blood circulation, and dredging collaterals and stopping bleeding when being used for treating the diabetic peripheral neuropathy; the traditional Chinese medicine fumigation and washing agent can be used for promoting blood circulation and dredging collaterals to treat the secondary symptoms, and also can be used for tonifying qi and nourishing yin to treat the primary symptoms; the treatment effect is obvious and no obvious side effect is caused; the traditional Chinese medicine fumigation and washing agent is low in price and convenient to use.