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Compound cortex phellodendri liquid coating mouthwash gel

A compound Phellodendron cortex liquid and gel technology, which is applied in anti-inflammatory agents, liquid delivery, pharmaceutical formulations, etc., can solve the problems of gel structure damage and complex components, and achieve the effect of promoting healing, good reproducibility, and reasonable composition Effect

Active Publication Date: 2018-01-16
SHANDONG HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex composition of traditional Chinese medicine extracts, they often interact with matrix excipients, or because the Chinese medicine extract is a hypertonic system, the water in the gel matrix network structure can leak out, thereby causing irreversible damage to the gel structure.

Method used

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  • Compound cortex phellodendri liquid coating mouthwash gel
  • Compound cortex phellodendri liquid coating mouthwash gel
  • Compound cortex phellodendri liquid coating mouthwash gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] 1. Research on the process of medicinal material extract

[0073] 1.1 Prescription

[0074] Forsythia 80±10g, Phellodendron 40±5g, Honeysuckle 40±5g, Dandelion 40±5g, Centipede 2.4±0.5g

[0075] 1.2 Extraction and purification process

[0076] 1.2.1 Herbal extracts

[0077] (1) Take the prescription amount of forsythia, Phellodendron cortex, honeysuckle, dandelion, add 6 times the amount of 70% ethanol for ultrasonic extraction 2-3 times;

[0078] (2) The alcohol extract is concentrated under reduced pressure (55°C) to a relative density of 1.00-1.05 (50°C);

[0079] (3) Add distilled water to 3-4 times the crude drug amount, stir evenly, and refrigerate for 12 hours to obtain the alcohol extract;

[0080] (4) Add 6 times the amount of water to the medicinal material residue after alcohol extraction, decoct and extract twice, 1 hour each time;

[0081] (5) The water extract is concentrated under reduced pressure (75°C) to a relative density of 1.10-1.15 (50°C);

...

Embodiment 2

[0101] 1. Research on the process of medicinal material extract

[0102] 1.1 Prescription

[0103] Forsythia 80±10g, Phellodendron 40±5g, Honeysuckle 40±5g, Dandelion 40±5g, Centipede 2.4±0.5g

[0104] 1.2 Extraction and purification process

[0105] 1.2.1 Herbal extracts

[0106] (1) Take the prescription amount of forsythia, Phellodendron cortex, honeysuckle, dandelion, add 6 times the amount of 70% ethanol for ultrasonic extraction 2-3 times;

[0107] (2) The alcohol extract is concentrated under reduced pressure (55°C) to a relative density of 1.00-1.05 (50°C);

[0108] (3) Add distilled water to 3-4 times the crude drug amount, stir evenly, and refrigerate for 12 hours to obtain the alcohol extract;

[0109] (4) Add 6 times the amount of water to the medicinal material residue after alcohol extraction, decoct and extract twice, 1 hour each time;

[0110] (5) The water extract is concentrated under reduced pressure (75°C) to a relative density of 1.10-1.15 (50°C);

...

Embodiment 3

[0127] Embodiment 3 analgesic test and antibacterial test

[0128] 1. Analgesic test:

[0129] 1. Test method

[0130] Kunming mice were used, and the mice were randomly divided into 3 groups: a model group, a compound Phellodendron liquid group (ie: commercially available compound Phellodendron liquid), and a compound Phellodendron liquid paint and mouthwash gel group. 5 mice per group.

[0131] The mice in each group were given the corresponding drug, the dosage was set at 10ml / kg, twice a day at 9:00-10:00 in the morning and 3:00-4:00 in the afternoon, for 3 consecutive days, and the last administration was 30 minutes Afterwards, 0.8% acetic acid (0.1ml / 10g) was injected intraperitoneally, and the number of writhing times of the mice in each group was observed after the injection of acetic acid for 15 minutes.

[0132] 2. Test results

[0133] Compared with the blank control group, the times of writhing of the mice in the Compound Phellodendron Liquid Group and the Comp...

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Abstract

The invention provides compound cortex phellodendri liquid coating mouthwash gel. The mouthwash gel comprises, by weight, 0.1 to 10% of chitosan, 0.1 to 2% of carbomer, 2 to 40% of glycerin, 0.05 to 0.1% of ethylparaben, 0.5 to 4.0% of triethanolamine, 2 to 10% of propylene glycol, 0.5 to 5% of Tween-80 and the balance of compound cortex phellodendri medical extract. The compound cortex phellodendri extract is prepared from a mixed liquid of medical plant extract and centipede enzymatic hydrolysate through cryoconcentration. According to the physical and chemical properties of effective components in the compound cortex phellodendri liquid and dosage forms, the gel matrix is preliminarily determined. The mouthwash gel can inhibit a variety of bacteria, forms a cured film on the ulcer surface to effectively isolate pathogens, has effects of diminishing inflammation, easing pain and promoting healing and can produce good curative effects on dental ulcer caused by radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to compound phellodendron liquid paint mouthwash gel and its preparation and application. Background technique [0002] According to the statistics of the World Health Organization, the current 5-year survival rate of malignant tumors is 45%. Radiotherapy and chemotherapy are one of the main treatment methods for malignant tumors. 60% to 70% of patients are treated with radiotherapy and chemotherapy as the first choice or comprehensive treatment. made of. In the treatment of oral and maxillofacial tumors, radiotherapy and chemotherapy also play a pivotal role. However, while radiotherapy and chemotherapy drugs can kill tumor cells and improve the cure rate of malignant tumors, they can also cause damage to normal tissues, leading to chemotherapy-induced oral ulcers. Barriers to treatment. [0003] Chemotherapy-induced oral ulcers usually occur 5 days after chemotherapy,...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/06A61K47/18A61K47/26A61K47/10A61K47/14A61P1/02A61P31/04A61P29/00A61K35/648
Inventor 秦承雪
Owner SHANDONG HANFANG PHARMA
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