18F-Fallypride automatically synthesizing method
An automated synthesis, sep-pakc-18 technology, applied in the direction of organic chemistry methods, chemical instruments and methods, isotope introduction of organic compounds, etc., can solve the problems of long time-consuming high-efficiency liquid phase purification, unfavorable clinical promotion and use, expensive preparative columns, etc. problems, achieve the effect of high labeling rate, easy operation and high synthesis efficiency
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[0018] Example 1
[0019] 18 F-Fallypride automatic synthesis method, using domestic PET-MF-2V-IT-I type multifunctional fluorine labeling module 18 Automated synthesis of F-Fallypride, using Sep-Pak C-18 column pair synthesis 18 Purification by F-Fallypride:
[0020] Accelerator production 18 After the F-solution is adsorbed by the QMA column, it is absorbed by the 1.5 mL of K in the bottle (1). 222 (50~300mg / mL) and K 2 CO 3 (2~8mg / mL) acetonitrile / water=10 / 1(V / V) solution eluted into the reaction tube (7), heated at 115℃ to remove acetonitrile, then added 2mL of acetonitrile in bottle (2) to the reaction tube Azeotropically remove water and acetonitrile, then add 4~5mg in bottle (3) 18 F-Fallypride labeled precursor. After reacting at 90°C for 25 minutes, cool, add 2 mL of 80% acetonitrile in the bottle (4) and mix with it, start the negative pressure to make the liquid in the reaction bottle pass through the tee after Sep-Pak C-18 column Into the waste bottle, the crude produc...
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