Gamithromycin emulsion, preparation method thereof and application of gamithromycin emulsion in prevention and treatment of porcine ileitis

Abstract

The invention relates to a gamithromycin emulsion. Each 100g of the gamithromycin emulsion comprises the following components by weight of 0.01 to 5.0 g of gamithromycin, 0.1 to 16.0 g of lysimachia christinae hance oil, 0.1 to 5.0 g of ethyl linoleate, 8.0 to 30.0 g of sucrose fatty acid ester, 10.0 to 20.0 g of polyoxyethylene ether (60) hydrogenated castor oil, 5.0 to 10.0 g of 1, 2-propylene glycol and the balance of deionized water. Meanwhile, the invention further discloses a preparation method, the process operability is high, and production conversion is facilitated. The emulsion disclosed by the invention is in an oil-water mutual wrapping type, the prepared product can be infinitely diluted with water and can also be infinitely diluted with oil, after being diluted with water, the emulsion can meet the drinking water administration requirement and is convenient to use, and after being diluted with oil, the emulsion can be prepared into a slow-release emulsion, so that a long-acting antibacterial effect is achieved, and the administration frequency is reduced. The emulsion disclosed by the invention can be used for preventing and treating ileitis diseases caused by pig Lawsonia intracellularis infection, has an effect obviously better than that of the prior art, and has a wide market application prospect.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a gamithromycin emulsion and its preparation method and its application in the prevention and treatment of ileitis caused by Lawsonia intracellulare infection. Background technique [0002] Lawsonia intracellularis is a pathogenic bacterium that mainly infects the ileum. The pathogen not only exists in the lumen of the ileum, but also parasitizes in the cells of the intestinal wall. It is a type of intracellular parasite. During the process of reproduction and metabolism, the bacteria can cause damage to the ileal wall cells, causing organic lesions in the mucosal tissue, resulting in ileitis symptoms such as diarrhea, malnutrition, slowed growth and development, and bloody stools in infected pigs. Long-term blood in the stool can cause anemia symptoms in pigs, and it is easy to die from secondary infection. Among the veterinary drugs used to treat this ...

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Problems solved by technology

[0004] Aiming at the treatment problems caused by Lawsonia intracellularis suis infection and the defects in the clinical promotion of Gamithromycin, the object of the present invention is to provide a Gamithromycin emulsion, which is in the form of mutual inclusion of oil phase and water, It solves the problem that the drug is insoluble in water, and can be infinitely diluted with water without precipitation, meeting the needs of clinical drinking water administration. At the same time, it can also be infinitely diluted with oil substances, and prepared into a liquid preparation with sustained release effect, which reduces the number of administrations and saves time. Save labor and save cost

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