Embolization polymer, novel blood vessel embolization chemotherapy composite as well as preparation and application of novel blood vessel embolization chemotherapy composite

Abstract

The invention provides an embolization polymer. The embolization polymer is prepared by performing polymerization reaction initiated by free radicals on micromolecule monomer containing unsaturated double bonds, monomer containing unsaturated double bonds and an optional cross-linking agent; the cross-linking agent is polyfunctionality water-soluble acrylate or acrylamide. The embolization polymeris an ion exchange microsphere carrier and has higher deformation ability and higher drug trapping efficiency and drug loading capacity; meanwhile, a slow release effect is better. The invention further provides a novel blood vessel embolization chemotherapy composite. The embolization chemotherapy composite disclosed by the invention can jointly deliver an embolization agent and chemotherapy drug to a target blood vessel part through a catheter, so that a curative effect of the chemotherapy drug is fully played, peripheral normal tissues are prevented from being damaged, and disease relapsing is reduced.

Description

technical field [0001] The invention belongs to the field of interventional medicine, and relates to an embolic polymer, a novel vascular embolization chemotherapy composition, a preparation method and application thereof. Background technique [0002] Interventional radiology is a new discipline developed in recent years. It is a minimally invasive medical technology guided by imaging equipment. It has the characteristics of small trauma, fast recovery, and good curative effect. treatment pathway. At present, it has become the three most important therapeutic disciplines along with internal medicine and surgery. Interventional embolization is an important part of interventional therapy, and it is increasingly playing an important role in the treatment of malignant tumors, vascular malformations, uterine fibroids and hemostasis. [0003] Arterial chemoembolization, or TACE treatment, combines embolization and chemotherapy. It is a non-surgical and minimally invasive tumor ...

AI Technical Summary

Problems solved by technology

There are several main defects in traditional TACE treatment: ① lipiodol emulsion will have local deposition, and as time goes on, the cytotoxic effect of the drug on the tumor will also decrease; ② although the emulsion reduces systemic adverse reactions compared with traditional chemotherapy, it still has Some drugs enter the circulatory system, increasing adverse reactions; ③In tumor treatment, the therapeutic effect requires maintaining a certain drug concentration inside the tumor, and this depends on the sustained release of drugs, which is difficult for lipiodol emulsions; ④Emulsion-Embolism The embolization operation is complicated, and chemoembolization cannot be completed in one step

Generally, the polymerization reaction is greatly affected by the chemical structure, degree of alcoholysis, degree of polymerization, molecular weight and viscosity of polymer materials, which makes the synthesis process of microspheres difficult to control, which in turn affects the physical and chemical properties and embolism properties of microspheres.

Images