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Application of lychee seed saponin in preparation of medicine for treating fatty liver

A technology of nucleoside and fatty liver is applied in the application field of lychee nucleoside in the preparation of a medicine for treating fatty liver, and the effect of improving the material basis is achieved.

Inactive Publication Date: 2021-12-17
广州医科大学附属中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, lychee core extract has been used clinically in diabetes and metabolic syndrome, and can achieve effective therapeutic effects, bringing good news to the treatment of diabetic patients
However, there is no relevant report on the use of lychee core extract for non-alcoholic steatohepatitis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Litchi core extract improves the material basis of NAFLD

[0019] 1.1 Identification of components extracted from litchi core:

[0020] Using the authorized patents of the research group (Guo Jiewen, Zhong Shishun, Ye Bibo, a preparation method for extracts of effective parts of litchi core, 2013-04-24, China, ZL201210012522.4; Guo Jiewen, Deng Zhijun, Qu Xiling, determination of litchi The method of saponin content in nuclear extract, 2015-08-05, China, ZL20131079692.7) method, identification of litchi nuclear saponin extract components.

[0021] 1.2 The effect and material basis of litchi core extract in improving NAFLD

[0022] (1) 6w-year-old normal wild-type mice were given litchi nucleoside extract by intragastric administration, divided into control group, high-dose group (1g / kg), middle-dose group (0.5g / kg), and low-dose group (0.25g / kg). Collect serum, detect ALT, AST and other indicators, detect different doses of liver toxicity; detect mouse weight, foo...

Embodiment 2

[0026] 1. The therapeutic effect of Arjunglucoside I (abbreviation: Arj I) on NAFLD

[0027] (1) Cell level

[0028] Taking the primary liver cells of wild-type mice as the research object, after 6 hours of culture in 1640 medium and changing the medium: ① Treat with different concentrations of Arj I (0-1mM), and use the CCK8 kit to detect the cell viability to determine the liver cells of different concentrations of Arj I. Cytotoxicity. ②Oleic acid and palmitic acid [OA (300 μM) & PA (100 μM)] were used to stimulate the model for 24 hours, and then treated with multiple concentrations of Arj I within the above safe concentration range for 24 hours, and the lipid accumulation in liver cells was directly observed by oil red experiment , Extract liver cells to detect triglyceride content, extract liver cell protein and RNA to detect changes in key genes of lipid metabolism such as PPARα and SREBP-1c by qPCR and WB (test methods are determined according to conventional methods)....

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PUM

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Abstract

The invention discloses an application of lychee seed saponin in preparation of a medicine for treating fatty liver, and belongs to the technical field of medicines. The invention specifically discloses an application of a lychee seed monomer Artungcoside I in preparation of the medicine for treating non-alcoholic fatty liver disease. According to the application of the lychee seed saponin in preparation of the medicine for treating the fatty liver, experiments verify that the lychee seed monomer Artungcoside I is used as an activating agent to activate an SIRT6-Nrf2 pathway, so that the effect of treating non-alcoholic fatty liver is realized, a direction and a basis are provided for clinically developing a new medicine for treating the non-alcoholic fatty liver disease, and a data support is provided for treating the non-alcoholic fatty liver disease.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of litchi nucleosides in the preparation of medicaments for treating fatty liver. Background technique [0002] Fatty liver refers to the lesion of excessive fat accumulation in liver cells caused by various reasons. It is a common pathological change of the liver, rather than an independent disease. Nonalcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by excessive fat deposition in liver cells caused by alcohol and other definite liver damage factors, and is closely related to the acquisition of insulin resistance and genetic susceptibility Metabolic stress-induced liver injury. Including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH) and related cirrhosis. Non-alcoholic fatty liver is very common clinically, and there are many drugs used to treat the disease, such as phosphatidylcholine, vitamin E, si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P1/16A61K131/00
CPCA61K36/77A61P1/16
Inventor 吴菲郭洁文江霞邓志军
Owner 广州医科大学附属中医医院