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Application of HTR6 in diagnosis and prognosis of breast cancer

A breast cancer and prognosis technology, applied in the field of breast cancer diagnosis, can solve the problem that the accuracy of breast cancer diagnosis needs to be improved, and achieve the effect of good clinical diagnosis value.

Pending Publication Date: 2022-01-18
SHENZHEN PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the accuracy of these serum markers for breast cancer diagnosis still needs to be improved

Method used

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  • Application of HTR6 in diagnosis and prognosis of breast cancer
  • Application of HTR6 in diagnosis and prognosis of breast cancer
  • Application of HTR6 in diagnosis and prognosis of breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The CCLE (Cancer Cell Line Encyclopedia, https: / / portals.broadinstitute.org / ccle) database contains multi-omics maps of thousands of cancer cell lines. Search the RNA-seq data of HTR6 in the CCLE database, and the results are as follows: figure 1 , it can be seen that the gene is expressed in many different tumor cell lines.

[0029]GEPIA (Gene Expression Profiling Interactive Analysis, http: / / gepia.cancer-pku.cn / ) is a visualization website based on the integration of GTEx and TCGA data. In GEPIA, the differential expression data of HTR6 in breast cancer and normal breast tissue were searched and analyzed. analysis, the result is as figure 2 As shown, the abscissa T is 1083 breast cancer patients, N is 291 normal people, and the ordinate is Transcripts Per Million (TPM). It can be seen from the figure that the expression of HTR6 is decreased in breast cancer compared with normal tissue or paracancerous tissue.

[0030] The expression of HTR6 in 44 breast cancer pati...

Embodiment 2

[0035] Tissue sections of patients with Luminal B breast cancer were selected, and the relative expression level of HTR6 protein was detected by immunohistochemical method, and the immunohistochemical score of the tissue was obtained accordingly. When the score was lower than the set threshold, it indicated that the patient had more High risk of poor prognosis.

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Abstract

The invention discloses an application of HTR6 in diagnosis and prognosis of breast cancer. On the first aspect, the invention provides an application of a reagent for quantitatively detecting HTR6 in preparation of kits for diagnosis and / or prognosis of breast cancer. The embodiment of the invention at least has beneficial effects of screening genes or proteins thereof with differential expression in breast cancer and normal breast tissues through a series of bioinformatics analysis methods. The HTR6 genes or the HTR6 proteins are provided as biomarkers for breast cancer diagnosis or continuous judgment on the progress or prognosis of the breast cancer for the first time, thereby making up for existing breast cancer diagnosis indexes and have good clinical diagnosis values.

Description

technical field [0001] This application relates to the technical field of breast cancer diagnosis, in particular to the application of HTR6 in the diagnosis and prognosis of breast cancer. Background technique [0002] Breast cancer is a relatively common malignant tumor, and it is also one of the tumors with a high mortality rate. The main cause of death of breast cancer is not the growth of carcinoma in situ. At present, the diagnosis of breast cancer includes clinical symptom diagnosis, pathological diagnosis and imaging diagnosis, but the indicators used in the diagnostic methods are often only obvious when the disease develops to a certain stage. indicative role. Among them, the pathological diagnosis is mainly tissue biopsy, which is cumbersome and time-consuming, difficult to sample, and the sampling process will cause damage to the subject. The imaging method scans through mammography, but the early accuracy of this method is low. In addition to the above methods,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886G01N33/57415C12Q2600/118G01N2333/70571
Inventor 戴勇张巍汤冬娥徐勇
Owner SHENZHEN PEOPLES HOSPITAL
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