Application of (4S,5S)-germacrone-4,5-epoxide in preparation of antibacterial and anti-inflammatory drugs

A technology of epoxy and geranone, applied in the field of medicine, can solve problems that have not been seen yet, and achieve good antibacterial and anti-inflammatory effects

Pending Publication Date: 2022-01-21
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(4S,5S)-geranone-4,5-epoxide is a sesquiterpene compound isolated from zedoary oil, and there is no related (4S,5S)-

Method used

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  • Application of (4S,5S)-germacrone-4,5-epoxide in preparation of antibacterial and anti-inflammatory drugs
  • Application of (4S,5S)-germacrone-4,5-epoxide in preparation of antibacterial and anti-inflammatory drugs
  • Application of (4S,5S)-germacrone-4,5-epoxide in preparation of antibacterial and anti-inflammatory drugs

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Embodiment Construction

[0014] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0015] 1) Source of material

[0016] 1.1) Cell lines:

[0017] RAW 264.7 cell line, purchased from Wuhan Prosai Life Technology Co., Ltd.;

[0018] 1.2) Main reagents:

[0019] (4S,5S)-geranone-4,5-epoxide was provided by Hainan Bikai Pharmaceutical Research Institute Co., Ltd.; Phosphate Buffered Saline (PBS) buffer, trypsin and penicillin-streptomycin solution were purchased from Gibco Company; RAW 264.7 cell-specific medium and fetal bovine serum were p...

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Abstract

The invention belongs to the technical field of medicines and particularly relates to application of (4S,5S)-germacrone-4,5-epoxide in preparation of antibacterial and anti-inflammatory drugs. Researches find that the (4S,5S)-germacrone-4,5-epoxide can be used for playing an anti-inflammatory effect by inhibiting expression levels of inflammation-related factors, has good antibacterial and anti-inflammatory effects, and is very suitable for being used as an active pharmaceutical ingredient of the antibacterial and anti-inflammatory drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of (4S,5S)-geranone-4,5-epoxide in the preparation of antibacterial and anti-inflammatory drugs. Background technique [0002] Inflammation is what is usually called "inflammation". It is a basic pathological process that occurs when biological tissues are stimulated by certain stimuli, such as trauma, infection and other damage factors. The local manifestations of inflammation are redness, swelling, heat, pain and dysfunction, and also accompanied by systemic reactions such as fever and changes in peripheral white blood cell count. [0003] In order to suppress the inflammatory response, a wide variety of antibacterial and anti-inflammatory drugs have been continuously developed. (4S,5S)-geranone-4,5-epoxide is a sesquiterpene compound isolated from zedoary oil, and there is no related (4S,5S)-geranone- A report on the application of 4,5-epoxide in...

Claims

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Application Information

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IPC IPC(8): A61K31/336A61P31/04A61P29/00
CPCA61K31/336A61P31/04A61P29/00
Inventor 徐扬毛庆秋陈容徐朗方方
Owner HAINAN BIKAI PHARM CO LTD
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