Encapsulated biochip

Abstract

The embodiment of the invention provides a packaged biochip which comprises a biochip and a chip support, wherein the biochip comprises a substrate and a probe fixed on the substrate, and the probe is used for capturing target biomolecules in a sample to be detected and forming recognizable fluorescence signals after being excited; the chip support comprises a bottom plate, an inner side wall and an outer side wall; one surface, on which the probe is fixed, of the biochip is downwards arranged on the inner side wall of the chip support, so that a closed hybridization space defined by the biochip and the chip support is formed; and the bottom plate of the chip support is also provided with two symmetrical liquid holes and sealing plugs matched with the liquid holes. The packaged biochip is simple in structure and low in cost, can be directly used for hybridization, cleaning, fluorescence excitation, imaging detection and other processes of the chip, is convenient to use and operate, can also be applied to the field of POCT, and has remarkable economic significance and social benefits.

Description

technical field [0001] The present invention relates to the field of testing instruments and equipment, in particular to the technical field of in vitro diagnostic testing and molecular diagnostic testing, in particular to a packaged biochip, more specifically to a low-to-medium density gene chip for immediate detection and protein chip. Background technique [0002] Biochip (biochip), in the early literature, is consistent with the concept of gene chip. With the in-depth research of technology, biochip broadly refers to the integration of biochemical analysis process on the chip surface according to the principle of specific interaction between biomolecules. Thus realizing high-throughput rapid detection of DNA, RNA, peptides, proteins and other biological components. According to the different types of probes immobilized on the surface of the chip, biochips are divided into gene chips, protein chips, tissue chips, and cell chips. China's biochip research began in 1997-19...

AI Technical Summary

Problems solved by technology

[0003] However, the low-to-medium density biochips currently on the market are often based on unpackaged bare gene chips, which generally need to be fenced and covered before hybridization. Cleaning after hybridization also requires special brackets and containers, resulting in biological The chip detection process is relatively complicated, and it cannot meet the requirements of convenient and fast POCT use, which limits the application of biochips in the field of POCT to a certain extent.

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