33 results about "Molecular Diagnostic Testing" patented technology

Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that have an up-regulation or a down- regulation in biomarker expression related to angiogenesis and vascular development. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti- angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used in different cancer types and with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

Apparatus and methods for practicing telemedicine in the form of software systems acting over a network and kits containing laboratory supplies and equipment to organize the laboratory operations and interpret the results of molecular diagnostic testing are disclosed. At least two computers in communication over the Internet or other network are used, a remote computer located at a remote site and a central server located at a central site. The remote site may be geographically distant from the central site. A specimen is procured from a patient proximate to the remote site. Laboratory operations are conducted on the specimen at the remote site. The laboratory data resulting from the laboratory operations is interpreted by an expert reviewer who may be located at the central site, and a report is then transmitted back to the remote site.

Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that are responsive to anti-angiogenesis therapeutics and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

The invention discloses a PCR instrument with multiple temperature control modules asynchronously selectable channels and a detection method thereof; it belongs to the field of medical inspection and testing instruments and molecular diagnosis and detection instruments; its technical gist is that it includes: m temperature control modules, m A reaction pool component module and a fluorescence detection component; the fluorescence detection module is an excitation light-receiving light integrated module structure; the optical fiber fixing plate is arranged with through holes, the number of the through holes, optical fibers, and reaction pools is the same, and the optical fiber and fluorescence detection module They are respectively located on both sides of the optical fiber fixing plate; one end of the optical fiber is fixedly communicated with the through holes one by one, and the other end is inserted into the reaction pool. The present invention aims to provide a PCR instrument with multiple temperature control modules asynchronously optional channels and a detection method thereof. A set of fluorescence detection system can collect the fluorescence signals of m PCR reaction pools without interfering with each other; the channels are optional and can be To better meet the needs of users and reduce costs, the universal enhancement of equipment.

A container for storing a biological sample for molecular diagnostic testing and / or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container and separates the two chambers. When the breakable membrane is broken, fluid can pass between the first and second chambers. The membrane may be broken through an activator on the closure, such as a depressible member or a rotatable carrier, causing the sample holder to break through the membrane.

The present disclosure relates to the identification of genes and gene combinations that are correlated with patients having or being predisposed to developing pancreatic ductal adenocarcinoma (PDAC). In some instances, methods herein utilize panels of 5 or 10 genes to accurately diagnose PDAC, determine the likelihood of developing PDAC, or determine the severity / stages of PDAC. These panels may be used in a molecular diagnostic test.

The invention discloses a nucleic acid extraction and amplification test tube and its working method, which belong to the field of molecular diagnosis and detection instruments, and its design points include: a PCR reaction tube, a lower tube of an extraction tube assembly, a middle tube of an extraction tube assembly, and an extraction tube assembly Upper tube assembly, top cover, piston rod, piston ring, first spool, second spring, second spool, third spring; extraction tube assembly upper tube assembly, extraction tube assembly middle tube, extraction tube assembly lower tube, The PCR reaction tubes are connected sequentially from top to bottom; the extraction tube assembly The upper tube assembly includes: two vertical parallel tube bodies: an extraction tube and a piston tube; a top cover is arranged on the top of the extraction tube; the piston rod is placed in the piston tube. The invention aims to provide a nucleic acid extraction and amplification test tube and its working method, which greatly improves the detection efficiency.