Salivary biomarkers for detection of epidermoid cancer of head and neck

A technique for epidermoid carcinoma, saliva, applied in the fields of biomaterial analysis, biochemical equipment and methods, and microbial determination/examination, etc., which can solve the problem of poor prognosis, no effective scheme for early detection of tumors, no showing the same trend, etc. question

Pending Publication Date: 2022-02-01
ビオノウリサーチエセエレ
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, analysis of the results at the genus or species level did not show the same trend
[0005] Epidermoid carcinoma of the head and neck is often diagnosed at an advanced stage of the disease and therefore has a poor prognosis
At present, it seems paradoxical that, with the means available, there are no effective protocols for the early detection of such tumors

Method used

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  • Salivary biomarkers for detection of epidermoid cancer of head and neck
  • Salivary biomarkers for detection of epidermoid cancer of head and neck
  • Salivary biomarkers for detection of epidermoid cancer of head and neck

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0139] Materials and methods

[0140] research group

[0141] All patients over the age of 18 with an anatomic pathological diagnosis of epidermoid carcinoma localized in the pharynx were studied.

[0142] sample

[0143] Saliva and tissue samples were collected by the Otorhinolaryngology and Molecular Biology Service, and informed consent was then given from all patients with benign and malignant head and neck tumors treated between January 2008 and December 2012 (inclusive) . An initial total sample of 179 patients was thus obtained.

[0144] Subsequently, a total of 20 patients were selected among these samples, and together with saliva samples from 20 healthy volunteers, the hypervariable region of the rS16 gene was analyzed in saliva samples. The sequencing results were analyzed at the Bioithas Biomedical Research Center located in the Alicante Science Park. Two groups of patients were selected to maintain homogeneity in their sociodemographic characteristics.

[01...

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PUM

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Abstract

Present invention relates to the in vitro use of the level or concentration in a salivary or breath sample of bacteria belonging to the Alloprevotella, Prevotella, Campylobacter, Rothia, Catonella, Porphyromona, Fretibacterium genus, or any combination thereof, for the diagnosis of carcinomas or epidermoid cancers, especially epidermoid cancer of the head and neck, in a patient, or to obtain useful data that allow such a diagnosis.

Description

technical field [0001] The present invention relates to a biomarker or combination of biomarkers in a saliva sample which, on the one hand, aids in the diagnosis of epidermoid carcinoma of the head and neck and, on the other hand, predicts response to treatment in subjects suffering from the disease. Background technique [0002] Epidermoid Cancer of the Head and Neck is a malignant neoplastic entity originating from the epithelium covering the mucosa of the aerodigestive tract. Its annual incidence rate is 700,000 patients, ranking sixth in the world among cancers with a high incidence rate. Of the 53,640 newly detected cases of head and neck tumors (oral cavity, pharynx, and larynx) in the United States in 2013, 95% corresponded to epidermoid carcinomas of the head and neck. According to the GLOBOCAN report in 2010, Spain is one of the countries with the highest incidence of epidermoid carcinoma of the head and neck in the entire European continent, as evidenced by the 11...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569C12Q1/6886G01N33/574C12Q1/689
CPCG01N33/57407G01N33/56955G01N2333/205C12Q1/6886C12Q1/689G01N33/56911C12Q2600/158C12Q2600/16
Inventor V·M·纳瓦罗·洛佩兹
Owner ビオノウリサーチエセエレ
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