Application of aspirin in preparation of medicine for preventing and treating unexplained recurrent abortion

A technique for recurrent miscarriage, aspirin, applied in the field of obstetrics and gynecology

Pending Publication Date: 2022-02-18
THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aspirin combined with low-molecular-weight heparin is commonly used in clinical treatment of recurrent miscarriage, and it has also been reported that low-dose aspirin targeting HMGB1 can reduce the risk of atherosclerotic complications, but there is no relevant research report on unexplained recurrent miscarriage

Method used

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  • Application of aspirin in preparation of medicine for preventing and treating unexplained recurrent abortion
  • Application of aspirin in preparation of medicine for preventing and treating unexplained recurrent abortion
  • Application of aspirin in preparation of medicine for preventing and treating unexplained recurrent abortion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The test of low-dose aspirin of the present invention based on HMGB1 to protect unexplained recurrent miscarriage is as follows:

[0025] (1) Low-dose aspirin targets HMGB1 to protect unexplained recurrent miscarriage. The implementation of the technology is as follows:

[0026] Purchase 8-10-week-old female CBA / J mice and male DBA / 2J mice from Beijing Huafukang Biotechnology Co., Ltd., and purchase 8-10-week-old male BALB / c mice from the Experimental Animal Center of Anhui Medical University. mouse. All mice were adaptively fed for 1 week in a standard environment with a constant temperature of 21-23° C. and a humidity of 50-60%, and were given autoclaved water and food.

[0027] After one week of adaptive feeding, all female CBA / J mice were randomly divided into three groups, namely the control group (Control group, CBA / J♀×BALB / c♂), the model group (URSA group, CBA / J ♀×DBA / 2J♂) and the treatment group (URSA+ASPL group, CBA / J♀×DBA / 2J♂), 14 rats in each group, and the...

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Abstract

The invention relates to application of aspirin in preparation of a medicine for preventing and treating unexplained recurrent abortion. According to the invention, a small dose of aspirin is added into the drinking water of the unexplained recurrent abortion mouse, so that the embryo absorption rate is reduced, the inflammatory response of the decidua tissue of the mouse is improved, the HMGB1 level of the serum and the decidua tissue of the mouse is reduced, and the proinflammatory response further caused by the high-level HMGB1 of the unexplained recurrent abortion mouse is prevented; further, the pregnancy rate of the mice with unexplained recurrent abortion is effectively protected and treated.

Description

technical field [0001] The invention relates to the application of aspirin in the preparation of medicines for preventing and treating unexplained recurrent miscarriage, and belongs to the field of obstetrics and gynecology. Background technique [0002] Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an incidence rate of 1%-5% in women of childbearing age. The currently known etiology is complex and diverse, including abnormal genetic factors, abnormal anatomical factors, abnormal endocrine function, and abnormal immune function. abortion, URSA) [1] . For such patients, there is no specific drug for treatment so far, and it is impossible to identify the etiology of unexplained recurrent miscarriage, which brings a heavy burden to the physical and mental health of women of childbearing age and their families. [0003] Recurrent miscarriage lacks specific clinical manifestations, and some treatment measures are currently controversial, and its...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K9/08A61P15/06
CPCA61K31/616A61K9/0095A61P15/06
Inventor 许孝凤邹慧娟朱大敏曹云霞汪晶尹佳倩
Owner THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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