Use of parasites and extracellular vesicles obtained from parasites in cancer treatment

A technology for cancer treatment and parasites, applied in the field of parasites and the use of extracellular vesicles obtained from parasites in cancer treatment, can solve the problems of disturbing the mental health of patients and reducing the effect of chemotherapy

Pending Publication Date: 2022-02-18
YEDITEPE UNIVSI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] •Sleep problems: Although it usually occurs due to psychological reasons, not being able to rest the body, especially during chemotherapy treatment, not only reduces the effectiveness of chemotherapy, but further disrupts the patient's mental health

Method used

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  • Use of parasites and extracellular vesicles obtained from parasites in cancer treatment
  • Use of parasites and extracellular vesicles obtained from parasites in cancer treatment
  • Use of parasites and extracellular vesicles obtained from parasites in cancer treatment

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Embodiment Construction

[0032] "Use of parasites and extracellular vesicles obtained from parasites in the treatment of cancer" developed for the purposes of the present invention is illustrated in the accompanying drawings, wherein:

[0033] figure 1 is a graphical representation of the apoptotic effect on cells of U87 cells incubated with two different doses of Leishmania infantum parasites.

[0034] figure 2 is a view of a light microscope photograph showing parasite infection after incubation of U87 cells with parasites in culture medium for 8 hours.

[0035] image 3 is a graphical representation of the effect of exosomes obtained from the Leishmania infantum parasite administered for 24, 48 and 72 hours at 8 different doses on the cell viability of U87 cells.

[0036] Figure 4 is a graphical representation of the effect of exosomes obtained from the Leishmania infantum parasite administered for 24, 48 and 72 hours at 8 different doses on the cell viability of A172 cells.

[0037] Figu...

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Abstract

The present invention relates to use of parasites and extracellular vesicles obtained from parasites for cancer treatment. The invention aims use of parasites and extracellular vesicles obtained from parasites in treatment of cancer, and loading active substance on exosomes by using the drug loading capacity of exosomes, and thus, by carrying specific drug directly to the target cancer cells without causing any side effect on the healthy cells and thereby enhancing bioavailability of the drug, achieving the desired effect in the tumor specific target region. Within the scope of the invention, particularly Leishmania infantum parasite is used as a source for extracellular vesicles.

Description

technical field [0001] The present invention relates to the use of parasites and extracellular vesicles obtained from parasites for cancer therapy purposes. Background technique [0002] Cancer is one of the most dangerous and common diseases today. An estimated 14.1 million new cancer cases were diagnosed worldwide in 2012 [1]. Although many different chemical and biological agents have been tried in cancer treatment, the developed treatments are insufficient due to their low efficacy and high side effects. For example, chemotherapy is the most commonly used treatment for many types of cancer, such as breast cancer, but it causes severe damage to many healthy tissues in the body, such as bone marrow, hair, and the digestive system [2]. A shortage of treatments has forced scientists to try new approaches in the field of cancer. In these trials, exosomes are expected to yield effective results. [0003] The term "neoplastic disease" as used within the scope of this applic...

Claims

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Application Information

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IPC IPC(8): A61K39/00A61K35/68
CPCA61K35/68A61K35/62A61K45/06C12N5/0601Y02A50/30A61P35/00A61K39/008A61K39/39A61K2039/55588
Inventor F·萨欣Z·伊斯莱克E·塔斯坎P·N·塔斯利B·T·博兹库特O·K·基尔巴什M·H·乌茨西克
Owner YEDITEPE UNIVSI
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