Active compound for inhibiting insulin resistance and application thereof

A technology of insulin resistance and compounds, applied in the field of medicine and biology, to achieve the effect of inhibiting insulin resistance activity and synergistically inhibiting insulin resistance activity

Active Publication Date: 2022-03-01
黑龙江护理高等专科学校
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The inventor of the present application has also been committed to the research of Hypericum adenocarpi for a long time and has published many academic papers, for example, Wang Yanli etc. " the effect of total flavonoids of Hypericum adenocarba on the inward rectification potassium current of rat cardiomyocyte arrhythmia model Influence." Chinese Journal of Traditional Chinese Medicine (2016). Another example, Wang Yanli, et al."Influence of total flavonoids from Hypericum attenuatum Choisy on inward rectifier potassium current of ratcardiac muscle c

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Materials

[0020] 1.1 Hyperin (hereinafter referred to as compound 1) and 5,7,3', 4'-tetrahydroxyflavanol (hereinafter referred to as compound 2) were separated and purified by chromatographic techniques according to literature methods (Dong Jianyong et al. Research on chemical constituents of flavonoids in Chinese herbal medicine [J]. Chinese Journal of Pharmaceutical Sciences, 2005, 40(12):897-899.)

[0021] 1.2 Experimental animals

[0022] 200 3-week-old SPF female SD rats were raised in the Animal Center of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine. 25°C constant temperature (50% humidity) clean-grade breeding, without feeding vitamin products, 12h light and 12h dark cycle alternately.

[0023] 2 Experimental methods

[0024] 2.1 Establishment of IR rat model

[0025] Insulin resistance rat model was established by feeding high-fat and high-sugar diet. Feed formula (g / 100g): fructose 60%, fat 15%, protein 21%,...

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PUM

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Abstract

The invention relates to a compound for inhibiting insulin resistance activity and application thereof. The compound is selected from one or a combination of hyperoside and 5, 7, 3 ', 4'-tetrahydroxyflavanol. Hyperoside and 5, 7, 3 ', 4'-tetrahydroxyflavanol have the activity of inhibiting insulin resistance, especially when the hyperoside and the 5, 7, 3 ', 4'-tetrahydroxyflavanol are combined according to a specific proportion, the effect of synergistically inhibiting the insulin resistance activity of the hyperoside and the 5, 7, 3 ', 4'-tetrahydroxyflavanol can be achieved, and the application has important significance for providing a novel medicine for treating type 2 diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to an active compound for inhibiting insulin resistance and its application. Background technique [0002] Insulin resistance (Insulin resistance, IR) refers to the reduction of the biological effect of insulin in the blood, that is, a state in which the body's responsiveness to the biological regulation of insulin is reduced, and insulin's ability to promote glucose uptake is impaired, resulting in increased compensatory insulin secretion. , and its important sign is hyperinsulinemia, which is manifested as a decrease in the sensitivity of peripheral tissues to insulin and an obstacle to the utilization of glucose. Insulin resistance is the common pathophysiological basis of many diseases of metabolic syndrome, such as obesity, hyperglycemia, type 2 diabetes, hyperlipidemia, coronary heart disease, hypertension, atherosclerotic coronary heart disease, etc. ...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K31/7048A61P3/10A61P5/50
CPCA61K31/353A61K31/7048A61P3/10A61P5/50A61K2300/00
Inventor 王艳丽高彩梅朴春妍邵靖宇宋辞隋思逸李学佳孔德凤
Owner 黑龙江护理高等专科学校
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