Active compound for inhibiting insulin resistance and application thereof

Abstract

The invention relates to a compound for inhibiting insulin resistance activity and application thereof. The compound is selected from one or a combination of hyperoside and 5, 7, 3 ', 4'-tetrahydroxyflavanol. Hyperoside and 5, 7, 3 ', 4'-tetrahydroxyflavanol have the activity of inhibiting insulin resistance, especially when the hyperoside and the 5, 7, 3 ', 4'-tetrahydroxyflavanol are combined according to a specific proportion, the effect of synergistically inhibiting the insulin resistance activity of the hyperoside and the 5, 7, 3 ', 4'-tetrahydroxyflavanol can be achieved, and the application has important significance for providing a novel medicine for treating type 2 diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and in particular relates to an active compound for inhibiting insulin resistance and its application. Background technique [0002] Insulin resistance (Insulin resistance, IR) refers to the reduction of the biological effect of insulin in the blood, that is, a state in which the body's responsiveness to the biological regulation of insulin is reduced, and insulin's ability to promote glucose uptake is impaired, resulting in increased compensatory insulin secretion. , and its important sign is hyperinsulinemia, which is manifested as a decrease in the sensitivity of peripheral tissues to insulin and an obstacle to the utilization of glucose. Insulin resistance is the common pathophysiological basis of many diseases of metabolic syndrome, such as obesity, hyperglycemia, type 2 diabetes, hyperlipidemia, coronary heart disease, hypertension, atherosclerotic coronary heart disease, etc. ...

AI Technical Summary

Problems solved by technology

[0005] The inventor of the present application has also been committed to the research of Hypericum adenocarpi for a long time and has published many academic papers, for example, Wang Yanli etc. " the effect of total flavonoids of Hypericum adenocarba on the inward rectification potassium current of rat cardiomyocyte arrhythmia model Influence." Chinese Journal of Traditional Chinese Medicine (2016). Another example, Wang Yanli, et al."Influence of total flavonoids from Hypericum attenuatum Choisy on inward rectifier potassium current of ratcardiac muscle cell arrhythmia model." Chinese Journal of Traditional Chinese Medicine 031.002(2016):656 -658. Another example, Feng Y, Teng L, Wang Y, et al. Using Spectrum-Effect Relationships Coupled with LC–TOF–MS to Screen Anti-arrhythmic Components of the Total Flavonoids in Hypericum attenuatum Extracts[J].Journal of Chromatographic Science , 2020. However, there is no literature report on whether there is an active compound that can inhibit insulin resistance in St. Active compounds for insulin resistance, and the present invention has been accomplished accordingly