40 results about "Flavanolol" patented technology

The invention discloses a type of flavanol (isobutene flavanol) compounds. The structural formulae of the compounds are shown in the specifications. The compounds have good inhibiting actions on urease, and can be used for preparing medicaments for resisting gastritis, gastric ulcer, lithangiuria and the like. The invention further discloses a preparation method of the compounds.

The invention provides a gene SmLAC1, which is a salvia miltiorrhiza laccase gene, and the sequence of the salvia miltiorrhiza laccase gene SmLAC1 is as shown in SEQ ID NO. 1; the sequence of the SmLAC1 protein is as shown in SEQ ID NO. 2; an expression vector carrying the SmLAC1 is transformed into a living body, so that the content of procyanidine in a plant body can be increased; and organisms comprise microorganisms and plants, and the proanthocyanidins are dimers of proanthocyanidins B1, B2 and B3. The gene is cloned from a salvia miltiorrhiza plant for the first time, and the encoded protein can catalyze flavan-3-ol to polymerize into the procyanidine, has application value in the aspect of production of effective active substances, provides a new way for large-scale production of the procyanidine, and also lays a solid foundation for industrial production of other related procyanidine.

Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I)

wherein R¹ through R³ and R⁵ through R¹¹ are defined herein, and α, β, and γ are optional bonds, providing that when α is absent, β is present, and when β is absent, α is present. When α is present, preferred R⁴ moieties are selected from O, S, NH and CH₂, and when α is absent, preferred R⁴ groups are selected from OH, SH, NH₂ and CH₃. When γ is present, the preferred R⁵ substituent is O, while when γ is absent, the preferred R⁵ substituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

The invention discloses a method for analyzing a proanthocyanidin structure through combination of hydrophilic interaction and reversed-phase liquid chromatography. The method comprises the following steps: analyzing a flavan-3-alcohol monomer; carrying out acid degradation on the proanthocyanidin to obtain an acid degradation product to be analyzed; analyzing the acid degradation product to be analyzed by using reversed-phase liquid chromatography (RPLC), analyzing the type and content of terminal units of proanthocyanidin according to the difference of the type and content of flavane-3-alcohol analyzed by the RPLC and Hilic, and analyzing the type and content of extension units of proanthocyanidin according to the flavane-3-alcohol-phloroglucinol addition product analyzed by the RPLC and the anthocyanidin; and calculating the average polymerization degree of the proanthocyanidin according to the mole number of the proanthocyanidin extension unit and the mole number of the terminal unit. According to the scheme, the step of directly removing flavane-3-alcohol in a sample in a traditional method (time consumption is long) is replaced, and the analysis speed of the terminal unit of the proanthocyanidin is greatly increased.

This invention relates to a composition, preferably in the form of a beverage, whereby cellular hydration and drinkability are enhanced by the combination of green tea solids with selected levels and types of electrolytes and carbohydrates. The compositions comprise (a) from about 0.01 % to about 0.35 % flavanols; (b) from about 0.01 % to about 0.3 % sodium ions; (c) from about 0.005 % to about 0.08 % potassium ions; (d) from about 0.1 % to about 20 % of a carbohydrate which provides: (i) from about 0.05 % to about 10.0 % fructose; (ii) from about 0.05 % to about 10.0 % glucose; and (e) water.

The invention provides 19 novel flavanol-fatty alcohol hybrids, as shown in a structural formula (I), tsaokoflavanols A-S 1-19, as well as a preparation method, pharmaceutical composition and application thereof, and relates to the technical field of medicines. The compound disclosed by the invention has obvious inhibitory activity on PTP1B and alpha-glucosidase, can form the pharmaceutical composition together with a medicinal carrier or an excipient, and can be used for preparing PTP1B and alpha-glucosidase inhibitor drugs, hypoglycemic drugs or health-care foods.

The present invention relates to a composition for improving intestinal barrier function, the composition containing a compound having a gallic acid residue as an active ingredient, wherein the compound having a gallic acid residue is at least one compound selected from the group consisting of the following (A1) to (A3): (A1) a flavan-3-ol polymer having a galloyl group; (A2) a hydrolyzable tannin; and (A3) at least one compound selected from the group consisting of catechin gallate, epicatechin gallate, and gallocatechin gallate.

The invention belongs to the technical field of flavanol substance detection, and discloses an SPE-DES-HPLC method for simultaneously determining two flavanol substances in Shanxi mature vinegar. According to the method, a Dimonsil C18 chromatographic column is selected, and the flow velocity is 1mL/min; the sample size is 10 [mu] L; the detection wavelength is 280 nm; a mobile phase is a 0.1% phosphate buffer and acetonitrile; and gradient elution is carried out. Through an optimization experiment, when the dosage of the activated XAD-2 macroporous adsorption resin is finally determined to be 188mg, the volume of the eutectic solvent (tetraethylammonium chloride-n-caprylic acid in a molar ratio of 1: 3) is 400mu L, the adsorption time is 11min, and the analysis time is 20min, the enrichment effect of the two flavanol substances is optimal. Under the condition, the linear relation of catechin and epicatechin is sound (R2 > 0.99), and compared with the tedious process of traditional solid-phase extraction, the detection limit, the quantitation limit, the intraday and interday relative standard deviation and the adding standard recovery rate show that the method is simpler, more convenient, high in sensitivity and small in matrix interference, and is suitable for enrichment determination of catechin and epicatechin in Shanxi mature vinegar.

The invention relates to a compound for inhibiting insulin resistance activity and application thereof. The compound is selected from one or a combination of hyperoside and 5, 7, 3 ', 4'-tetrahydroxyflavanol. Hyperoside and 5, 7, 3 ', 4'-tetrahydroxyflavanol have the activity of inhibiting insulin resistance, especially when the hyperoside and the 5, 7, 3 ', 4'-tetrahydroxyflavanol are combined according to a specific proportion, the effect of synergistically inhibiting the insulin resistance activity of the hyperoside and the 5, 7, 3 ', 4'-tetrahydroxyflavanol can be achieved, and the application has important significance for providing a novel medicine for treating type 2 diabetes mellitus.

The invention relates to a flavane-3-alcohol acylpropanoid heterocomplex and a preparation method and application thereof, and belongs to the technical field of natural pharmaceutical chemistry and medicine. The inventor of the invention separates a new flavane-3-alcohol acylpropanoid heterocomplex from the whole herb of mentha piperita, and accidentally finds that the compound has an obvious anti-inflammatory effect in a further pharmacodynamic research process. The flavane-3-alcohol acylpropanoid heterocomplex disclosed by the invention has a clinical application prospect of an anti-inflammatory drug.

The invention discloses a preparation method of a gelatin-based food packaging film, which comprises the following steps: 1) mixing and soaking 16-30 parts by mass of gelatin and 100 parts by mass ofdistilled water for 0.5-1.5 hours to obtain a gelatin matrix; 2) adding 15-25 parts of a titanium compound aqueous solution with the concentration of 3-10g/L into the gelatin matrix; and adding 15-25parts of 0.5-2g/L high-polymerization-degree flavanol aqueous solution, adding 3-6 parts of 0.1-1.2 mol/L sodium hydroxide aqueous solution and 3-6 parts of glycerol, casting to form a film, and drying to obtain the finished product. According to the preparation method, natural polyflavanol and high-safety titanium ions are used as composite cross-linking agents, and the high-safety gelatin-basedfood packaging film with excellent physical and mechanical properties is prepared by utilizing a principle that protein reaction active sites are increased after the titanium ions and the polyflavanolform a coordination compound.

An anti-allergenic composition comprising from about 0.01% to about 50% by weight of a polyphenol, from about 0.01% to about 50% by weight of a terpene compound, and from about 0.001% to about 10% byweight of a glycolipid. The polyphenol has a flavanol derivative. The terpene compound can be selected from the group consisting of a terpene, terpinene, a terpene derivative and combinations thereof.In an embodiment, the sphingolipid comprises about 0.2% phytosphingosine.

The invention provides eight new flavanol-menthane polymers shown as a structural formula (I), namely amomutsaokins A-H (compounds 1-8), a preparation method, a pharmaceutical composition and application thereof, and relates to the technical field of medicines. The provided compounds have obvious inhibitory activity on PTP1B and alpha-glucosidase, can form a pharmaceutical composition with a medicinal carrier or excipient, and can be used for preparing PTP1B and alpha-glucosidase inhibitor drugs, hypoglycemic drugs or health foods.