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A kind of flavan-3-ol phenylpropanoid hybrid compound, its preparation method and application

A kind of technology of acetaminophen and hybrid compound, which is applied in the field of flavan-3-alcohol acetaminophen hybrid, and can solve problems such as body damage, excessive inflammatory response and the like

Active Publication Date: 2022-04-22
FENGXIAN CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inflammatory response is too strong and severe, which can lead to serious damage to the body

Method used

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  • A kind of flavan-3-ol phenylpropanoid hybrid compound, its preparation method and application
  • A kind of flavan-3-ol phenylpropanoid hybrid compound, its preparation method and application
  • A kind of flavan-3-ol phenylpropanoid hybrid compound, its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0061] Step 1): The dry whole herb of peppermint from the above sources is crushed to a powder (10kg) with a mesh size of 10 mesh or less;

[0062] Step 2): For the powder obtained in the step 1), use 75% (volume ratio) ethanol to carry out reflux extraction, reflux extraction 3 times, each time for 1 to 2 hours, filter and combine the extract; extract the combined extract Obtain the total extract after concentrating under reduced pressure;

[0063] Step 3): Disperse the total extract obtained in the step 2) in water, sequentially extract with equal volumes of petroleum ether and ethyl acetate (each solvent extracts 4 times), recover the solvent under reduced pressure, and obtain petroleum Ether phase extract, and ethyl acetate phase extract (about 87.5g);

[0064] Step 4): The ethyl acetate phase extract obtained in the step 3) is subjected to silica gel column chromatography, and the silica gel column chromatography adopts petroleum ether-ethyl acetate-acetone system for gr...

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Abstract

The present invention relates to a flavan-3-alcohol phenylpropanoid hybrid compound, its preparation method and application, and belongs to the field of natural medicinal chemistry and medical technology; the inventor of the present invention obtained a A new flavan-3-alcohol-phenylpropanoid hybrid, and in the course of further pharmacodynamic research, it was unexpectedly found that the compound has obvious anti-inflammatory effects; the flavan-3-alcohol-phenylpropanoid The protein hybrid has a clinical application prospect as an anti-inflammatory drug.

Description

technical field [0001] The invention relates to a flavan-3-ol phenylpropanoid hybrid compound, a preparation method and application thereof, and belongs to the technical fields of natural medicine chemistry and medicine. Background technique [0002] Inflammation is the defense response of living tissue with vascular system to damage factors, and is a defense response of the body to stimulation, manifested as redness, swelling, heat, pain and dysfunction. The inflammatory response is essentially a protective response produced by the body against the invasion of harmful factors to maintain the stability of the internal environment. It belongs to the category of natural immunity and is usually beneficial to the body. However, the inflammatory response is too strong and severe, which can lead to serious damage to the body. Current clinical studies have found that acute lung injury, arthritis, rheumatoid arthritis and other diseases are all related to inflammatory response. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04A61K31/352A61P29/00A61K36/534
CPCC07D493/04A61P29/00A61K36/534
Inventor 王曼马爱勤陆义安李锴
Owner FENGXIAN CENT HOSPITAL
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