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Flavane-3-alcohol acylpropanoid heterocomplex and preparation method and application thereof

A technology of alcohol phenylpropanoids and hybrids, which is applied in the field of flavan-3-ol phenylpropanoids hybrids, and can solve problems such as excessive inflammatory response and body damage

Active Publication Date: 2021-06-25
FENGXIAN CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inflammatory response is too strong and severe, which can lead to serious damage to the body

Method used

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  • Flavane-3-alcohol acylpropanoid heterocomplex and preparation method and application thereof
  • Flavane-3-alcohol acylpropanoid heterocomplex and preparation method and application thereof
  • Flavane-3-alcohol acylpropanoid heterocomplex and preparation method and application thereof

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Experimental program
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Embodiment 1

[0061] Step 1): The dry whole herb of peppermint from the above sources is crushed to a powder (10kg) with a mesh size of 10 mesh or less;

[0062] Step 2): For the powder obtained in the step 1), use 75% (volume ratio) ethanol to carry out reflux extraction, reflux extraction 3 times, each time for 1 to 2 hours, filter and combine the extract; extract the combined extract Obtain the total extract after concentrating under reduced pressure;

[0063] Step 3): Disperse the total extract obtained in the step 2) in water, sequentially extract with equal volumes of petroleum ether and ethyl acetate (each solvent extracts 4 times), recover the solvent under reduced pressure, and obtain petroleum Ether phase extract, and ethyl acetate phase extract (about 87.5g);

[0064] Step 4): The ethyl acetate phase extract obtained in the step 3) is subjected to silica gel column chromatography, and the silica gel column chromatography adopts petroleum ether-ethyl acetate-acetone system for gr...

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Abstract

The invention relates to a flavane-3-alcohol acylpropanoid heterocomplex and a preparation method and application thereof, and belongs to the technical field of natural pharmaceutical chemistry and medicine. The inventor of the invention separates a new flavane-3-alcohol acylpropanoid heterocomplex from the whole herb of mentha piperita, and accidentally finds that the compound has an obvious anti-inflammatory effect in a further pharmacodynamic research process. The flavane-3-alcohol acylpropanoid heterocomplex disclosed by the invention has a clinical application prospect of an anti-inflammatory drug.

Description

technical field [0001] The invention relates to a flavan-3-ol phenylpropanoid hybrid compound, a preparation method and application thereof, and belongs to the technical fields of natural medicine chemistry and medicine. Background technique [0002] Inflammation is the defense response of living tissue with vascular system to damage factors, and is a defense response of the body to stimulation, manifested as redness, swelling, heat, pain and dysfunction. The inflammatory response is essentially a protective response produced by the body against the invasion of harmful factors to maintain the stability of the internal environment. It belongs to the category of natural immunity and is usually beneficial to the body. However, the inflammatory response is too strong and severe, which can lead to serious damage to the body. Current clinical studies have found that acute lung injury, arthritis, rheumatoid arthritis and other diseases are all related to inflammatory response. ...

Claims

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Application Information

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IPC IPC(8): C07D493/04A61K31/352A61P29/00A61K36/534
CPCC07D493/04A61P29/00A61K36/534
Inventor 王曼马爱勤陆义安李锴
Owner FENGXIAN CENT HOSPITAL
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