Composition for promoting expression of aquaporin 3

A technology of aquaporin and composition, which is applied in the direction of drug combination, food ingredients containing organic compounds, applications, etc., and can solve the problems of slow wound healing and reduced elasticity of skin tissue

Inactive Publication Date: 2020-05-19
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, it has been reported that when the expression of AQP3 is lost, the elasticity of the skin tissue will be reduced and dry, and the healing of the wound will be slowed down (Non-Patent Document 4)

Method used

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  • Composition for promoting expression of aquaporin 3
  • Composition for promoting expression of aquaporin 3
  • Composition for promoting expression of aquaporin 3

Examples

Experimental program
Comparison scheme
Effect test

no. 1 Embodiment approach

[0148] Next, the composition according to the first embodiment of the present invention will be described. The composition according to the first embodiment is a composition for improving skin moisture, which contains a galloyl group-containing flavan-3-ol monomer and / or a galloyl group-containing flavan-3-ol monomer as an active ingredient. Compositions of alcohol polymers that enhance skin moisturization by increasing aquaporin-3 expression.

[0149] The method of using the composition according to the first embodiment of the present invention is not particularly limited, and it can be absorbed into the body by oral intake, or applied to the skin by coating or the like.

[0150] Among these, the method of absorbing into the body by oral intake is preferable.

[0151] In addition, in this specification, "moisture of the skin" means the state which retains moisture in a stratum corneum.

[0152] In addition, in this specification, the so-called "improving the moisture of the...

no. 2 Embodiment approach

[0172] Next, the composition according to the second embodiment of the present invention will be described. The composition according to the second embodiment is a composition for promoting expression of aquaporin 3, which contains a galloyl group-containing flavan-3-ol monomer and / or a galloyl group-containing flavan-3-ol monomer as an active ingredient. Compositions of 3-alcohol polymers.

[0173] Galloyl-containing flavan-3-ol monomers and / or galloyl-containing flavan-3-ol polymers have the ability to increase the expression of aquaporin 3, such as increasing the expression of aquaporin 3 in skin epithelial cells volume effect. Therefore, by using the composition related to the second embodiment of the present invention containing a flavan-3-ol monomer having a galloyl group and / or a flavan-3-ol polymer having a galloyl group, it is possible to promote aquaporin 3 expressions.

[0174] The composition according to the second embodiment of the present invention is prefera...

Embodiment 1

[0194] (Manufacturing method of grape extract (raw material derived from grapes))

[0195] The red wine is concentrated under reduced pressure, and the ethanol is distilled off as a grape extract. The OPC concentration of this grape extract was 15,000 ppm.

[0196] Here, extracts of grape-derived raw materials including grape seeds, such as wine, contain galloyl-containing flavan-3-ol polymers (proanthocyanidin B2-3'-O-gallate (hereinafter referred to as EC-ECG), Proanthocyanidin B4-3'-O-gallate (hereinafter referred to as C-ECG, etc.) and flavan-3-ol monomers with galloyl groups (epicatechin gallate (hereinafter referred to as ECG), etc.) (reference Document 1: "Comparative flavan-3-ol composition of seeds from different grape varieties" Food Chemistry 53(1995) 197-201, Reference 2: "PROCYANIDIN DIMERS AND TRIMERS FROM GRAPE SEEDS" Phytochemistry Vol.30.No.4, pp 1259-1264 1991, Reference 3: "The Functional Application of "Grape Seed Polyphenols"" NEW FOOD INDUSTRY Vol.43No....

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Abstract

The purpose of the present invention is to provide a specific composition for promoting expression of aquaporin 3, and the use of the composition. The present invention pertains to a composition for promoting expression of aquaporin 3, said composition including, as essential ingredients, a flavan-3-ol monomer having a galloyl group and / or a galloyl-group-containing flavan-3-ol polymer.

Description

technical field [0001] The invention relates to a composition for promoting the expression of aquaporin 3 and its use. Background technique [0002] Women's skin troubles and beauty-related expectations are mostly related to skin moisturizing and moisture, and research on techniques to improve skin moisture is currently in progress. [0003] Aquaporin (AQP) is known as such a protein capable of improving skin moisture. [0004] AQP is a protein discovered in 1992. It is a passage through water rapidly and in large quantities, and 13 types (AQP0-AQP12) have been confirmed to exist in humans. These AQPs are specifically distributed according to the kind of cells or tissues. AQP is distributed in almost all organs of human beings, especially in organs such as the kidney that transport a large amount of water. Their respective coordination functions include the production of urine, the secretion of digestive juices, the prevention of dryness, and the combination of cells Vari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K8/49A61K8/9789A61Q19/00
CPCA23L33/105A61Q19/00A61P17/00A61K8/498A61Q19/007Y02A50/30A61K8/9789A23V2002/00A23V2250/30A23V2200/318A61K31/351A61K36/87
Inventor 中村友美福井祐子土屋贵嗣泉玲子
Owner SUNTORY HLDG LTD
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