Flavanol-fatty alcohol hybrids as well as pharmaceutical composition, preparation method and application thereof

A technology of flavanols and fatty alcohols, applied in the directions of drug combination, application, pharmaceutical formulation, etc.
CN111978330APending Publication Date: 2020-11-24KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Publication Date
2020-11-24

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Abstract

The invention provides 19 novel flavanol-fatty alcohol hybrids, as shown in a structural formula (I), tsaokoflavanols A-S 1-19, as well as a preparation method, pharmaceutical composition and application thereof, and relates to the technical field of medicines. The compound disclosed by the invention has obvious inhibitory activity on PTP1B and alpha-glucosidase, can form the pharmaceutical composition together with a medicinal carrier or an excipient, and can be used for preparing PTP1B and alpha-glucosidase inhibitor drugs, hypoglycemic drugs or health-care foods.
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Description

Technical field:

[0001] The invention belongs to the technical field of medicines. Specifically, it involves 19 new flavanol-fatty alcohol hybrids, tsaokoflavanols A-S (tsaokoflavanols A-S, 1-19), their preparation methods and applications, pharmaceutical compositions and their applications. Background technique:

[0002] Type 2 diabetes is a chronic metabolic disease characterized by inappropriate postprandial hyperglycemia, resulting from pancreatic β-cell dysfunction and insulin resistance in the body. In 2017, more than 400 million people worldwide suffered from type 2 diabetes, and this number is expected to reach 600 million by 2045. The clinical methods used to treat type 2 diabetes mainly include exogenous injection of insulin and oral hypoglycemic drugs. According to different modes of action, commonly used oral hypoglycemic drugs can be divided into biguanides, α-glucosidase inhibitors, insulin secretion enhancers, insulin sensitizers, glucagon-like peptide 1 rec...

Claims

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