A kind of heather proanthocyanidin and its preparation method and application

A technology of proanthocyanidins and heather, which is applied in the fields of applications, pharmaceutical formulations, plant raw materials, etc., can solve the problems of less research reports on chemical components and biological activities, and achieve the effects of easy access to raw materials, good activity, and simple preparation methods

Inactive Publication Date: 2017-02-15
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the chemical constituents and biological activities of this genus.

Method used

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  • A kind of heather proanthocyanidin and its preparation method and application
  • A kind of heather proanthocyanidin and its preparation method and application
  • A kind of heather proanthocyanidin and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of embodiment 1 heather proanthocyanidins

[0034] Weigh 25g of dry heather infructescence rachis powder, place it in a 1000mL conical flask, add 800mL of 50% ethanol acidified with 0.5% (V / V) acetic acid, let it stand overnight, and place it in an ultrasonic generator at 40KHz the next day Ultrasonic extraction for 30min, Buchner funnel filtration, add 600mL 50% ethanol acidified with 0.5% acetic acid to the filter residue, ultrasonic extraction at 40KHz for 30min, Buchner funnel filtration, add 600mL 50% ethanol acidified with 0.5% acetic acid to the filter residue, 40KHz Ultrasonic extraction for 30 min, Buchner funnel filtration, three filtrates were combined, and the filtrate was concentrated under reduced pressure in a rotary evaporator at 45°C to obtain a concentrated extract, which was divided into two parts for macroporous resin purification.

[0035]Take 200g of new D101 macroporous resin, put it into a chromatography column, soak it wit...

Embodiment 2

[0045] The preparation method of embodiment 2 heather proanthocyanidins

[0046] Weigh 50g of dry Photinia glabra infructose rachis powder, put it in a 2000mL beaker, add 1500mL of 70% ethanol acidified with 1.0% (V / V) hydrochloric acid, let it stand overnight, and generate it by ultrasonic wave the next day. Ultrasonic extraction at 40KHz for 30min, Buchner funnel filtration, 1200mL of 70% ethanol acidified with 1.0% HCl was added to the filter residue, ultrasonic extraction at 40KHz for 30min, Buchner funnel filtration, and 1000mL of ethanol acidified with 1.0% HCl was added to the filter residue. 70% ethanol, ultrasonic extraction at 40KHz for 30min, Buchner funnel filtration, combined three filtrates, the filtrate was concentrated under reduced pressure in a rotary evaporator at 45°C to obtain a concentrated extract, which was used for macroporous resin purification.

[0047] Take 400g of new X-5 macroporous resin, put it into a chromatography column, soak it with 95% etha...

Embodiment 3

[0048] The preparation method of embodiment 3 heather proanthocyanidins

[0049] Weigh 50g of dried Photinia xfraseri infructescence axis coarse powder, put it in a 2000mL beaker, add 1500mL of 90% methanol acidified with 10% (V / V) acetic acid, let it stand overnight, and put it in an ultrasonic generator the next day medium, ultrasonically extract at 50KHz for 20min, filter with Buchner funnel, add 1200mL of 90% methanol acidified with 10% acetic acid to the filter residue, ultrasonically extract at 50KHz for 30min, filter with Buchner funnel, add 1000mL of 90% methanol acidified with 1.0% HCl to the filter residue % methanol, ultrasonic extraction at 50KHz for 60min, Buchner funnel filtration, combined three filtrates, the filtrate was concentrated under reduced pressure in a rotary evaporator at 45°C to obtain a concentrated extract, which was used for macroporous resin purification.

[0050] Take 400g of new AB-8 macroporous resin, put it into a chromatographic column, soa...

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Abstract

The invention discloses photinia serrulata procyanidine as well as a preparation method and an application thereof. The photinia serrulata procyanidine is prepared by extracting and purifying rachis of a photinia plant as an effective component. According to the photinia serrulata procyanidine as well as the preparation method and application, the branches, leaves and fruits of the photinia plant contain extremely high procyanidine like substances, and the matured rachis contain the most procyanidine; the plant extractive prepared through the rachis of the photinia plant by purifying has the antioxidant activity under low concentration higher than that as specified in the specification under the same mass concentration; and the chemical component analysis sheet shows that the contents of flavonoid components, phenol components and symbolic flavane-3-alcohol antioxidant components in the extractive are higher than that as specified in the specification. The raw materials of the extractive are easily obtained, the extracting process is simple, the cost is small, and wide market prospect and high economic value are brought.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and relates to heather proanthocyanidin and its preparation method and application. Background technique [0002] Since Denham Harman proposed the free radical theory of aging in 1956, people's attention and research on free radicals have been increasing day by day. With the increasing pressure of competition and the deterioration of the living environment, the health of organisms has been attacked by free radicals unprecedentedly. Free radicals directly lead to the damage of biofilms, affecting the metabolic balance of the body, leading to the aging of the body, and can cause various diseases such as cancer, diabetes, cardiovascular disease, and senile dementia. There is a set of free radical scavenging systems in organisms, including free radical scavenging enzyme systems and non-enzymatic systems, which maintain the body's free radical metabolic balance and repair the damage caused by...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61K8/9789A61P39/06A61Q19/08A23L33/10A23L2/52A23K10/30
Inventor 梁宗锁李鑫刘景玲毛仁俊杨星科
Owner NORTHWEST A & F UNIV
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