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Flavone-metal complex microsphere and preparation method and application thereof

A technology of metal complexation and flavonoids, which is applied in the field of flavone-metal complex microspheres and its preparation, can solve the problems that have not been reported in any reports, and achieve good biocompatibility, good acid resistance, and broad application prospects

Inactive Publication Date: 2013-04-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no reports about flavone-metal complex microspheres and their preparation

Method used

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  • Flavone-metal complex microsphere and preparation method and application thereof
  • Flavone-metal complex microsphere and preparation method and application thereof
  • Flavone-metal complex microsphere and preparation method and application thereof

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Embodiment 1

[0059] In the present embodiment, flavone-metal complex solid microspheres are prepared, and the process steps are as follows:

[0060] (1) Preparation of flavonoids solution

[0061] Add 0.01g of rutin to a reaction vessel containing 21mL of deionized water at normal pressure and room temperature, and dissolve the rutin completely under stirring;

[0062] (2) Reaction synthesis

[0063] Add Ag in the rutin aqueous solution prepared in step (1) under stirring + AgNO at a concentration of 0.06mol / L 3 Aqueous solution 1.5mL, auxiliary agent ethylene glycol 0.05mL to form a reaction solution, then use NaOH aqueous solution with a concentration of 0.1mol / L and HCl with a concentration of 0.1mol / L to adjust the pH value of the reaction solution, when the pH value of the reaction solution is stabilized at 6 , heated to 60°C for 15 hours at constant temperature under normal pressure;

[0064] (3) Product collection and drying

[0065] After the reaction, the precipitate was coll...

Embodiment 2

[0068] In the present embodiment, flavone-metal complex solid microspheres are prepared, and the process steps are as follows:

[0069] (1) Preparation of flavonoids solution

[0070] Add 0.1 kg of tea polyphenols into a reaction vessel containing 7.8 L of deionized water at normal pressure and room temperature, and dissolve the tea polyphenols completely under stirring;

[0071] (2) Reaction synthesis

[0072] Add Sr to the tea polyphenol aqueous solution prepared in step (1) under stirring 2+ SrCl with a concentration of 0.6mol / L 2 Aqueous solution 2.0L, auxiliary agent ethylene glycol 0.2L to form a reaction solution, then adjust the pH value of the reaction solution with a concentration of 0.5mol / L ammonia solution and a concentration of 0.5mol / L HCl, when the pH value of the reaction solution is stable at 8 , heated to 60°C for 15 hours at constant temperature under normal pressure;

[0073] (3) Product collection and drying

[0074] After the reaction, collect the p...

Embodiment 3

[0077] In the present embodiment, flavone-metal complex solid microspheres are prepared, and the process steps are as follows:

[0078] (1) Preparation of flavonoids solution

[0079] Add 1.0 g of flavanols into a reaction vessel containing 120 mL of deionized water at normal pressure and room temperature, and dissolve the flavanols completely under stirring;

[0080] (2) Reaction synthesis

[0081] Add Mg to the flavanol aqueous solution prepared in step (1) under stirring 2+ Concentration of 0.3mol / L MgSO 4 ·H 2O aqueous solution 25mL, auxiliary agent ethylene glycol 5mL form reaction solution, then adjust the pH value of reaction solution with the ammonia solution of concentration 0.5mol / L and the HCl of concentration 0.5mol / L, after the pH value of reaction solution is stable at 8, Heating to 70°C for 13 hours at constant temperature under normal pressure;

[0082] (3) Product collection and drying

[0083] After the reaction, collect the precipitate by filtration, a...

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Abstract

The invention relates to a flavone-metal complex microsphere which is in a spherical shape and in the structure of a solid sphere or a hollow sphere or a porous sphere, and the particle size of the sphere is 50nm-5000nm. The flavone-metal complex microsphere is formed by complexing flavonoid substances such as flavanol, anthocyanidin, tea polyphenol and the like with metal, and the preparation process comprises the following sequential steps: (1) preparing a flavone solution, (2) reacting and synthesizing, and (3) collecting and drying the product. In the reaction for synthesis, glycerin or glycol is used as an assistant, and the reaction temperature is 60 DEG C-70 DEG C for obtaining the solid microsphere. In the reaction for synthesis, ethyl acetate or vinyl alcohol is used as an assistant, and the reaction temperature is 90 DEG C-150 DEG C for obtaining the hollow microsphere. In the reaction for synthesis, ethanol is used as an assistant, and the reaction temperature is 70 DEG C-90 DEG C for obtaining the porous microsphere. The flavone-metal complex hollow microsphere can be used as a drug carrier or fluorescence molecular carrier for application.

Description

technical field [0001] The invention belongs to the field of metal-organic complexes, in particular to flavone-metal complex microspheres and a preparation method and application thereof. Background technique [0002] In recent years, the research on metal-organic coordination compounds (metal-organic framework, referred to as MOF) has further in-depth development. The application of metal-organic spheres in hydrogen storage materials, drug carriers, loading of functional material molecules, food, medicine and sanitation, and chemical catalysis has been widely concerned and studied (Imaze I, et al., Metal-Organic Spheres as Functional Systems for Guest Encapsulation, Angewandte Chemie International Edition, 2009, 48, 2325-2329). However, current MOS still has problems such as biological safety, lack of functionality of organic ligands, low drug loading, and lack of targeted release mechanism, etc. [0003] Flavonoids (polyphenols) have a strong complexing ability with meta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/00C07G99/00C07F3/02C07F3/00C07F13/00C07F3/06C07F1/08C07F15/02A61K47/26A61K47/24A61K9/16C09K11/06
Inventor 李旭东陈震华王彩红陈君泽周慧慧桑琳罗冬梅
Owner SICHUAN UNIV
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