Sensor with specificity for CFXs, recognition method and application

Abstract

The invention belongs to the technical field of sensors, and discloses a CFX-specific sensor, an identification method and application, and the manufacturing method of the CFX-specific sensor comprises the following steps: preparing Fe3O4-coated PtNPs by using a chemical coprecipitation method; the preparation of COF-AIECL is carried out through a condensation reaction; and manufacturing the sensor. According to the invention, an aggregation-induced ECL reagent is utilized to prepare a high-sensitivity novel molecular imprinting sensor for detecting ciprofloxacin (CFX). The result shows that the ECL signal of the COF-AIECL can be catalyzed and amplified by the Fe3O4 (at) PtNPs, and is obviously quenched by the CFX. According to the invention, an ECL signal is controlled by MIP elution and CFX adsorption, and a new CFX detection method is established. Therefore, the sensor developed by the invention shows good reproducibility, stability and selectivity on CFX detection.

Description

technical field [0001] The invention belongs to the technical field of sensors, and in particular relates to a sensor specific to _CFX_, a recognition method and an application. Background technique [0002] Currently, ciprofloxacin (CFX) is a commonly used third-generation fluoroquinolone antibacterial drug with high antibacterial activity. In addition to its strong antibacterial effect, CFX also has a broad antibacterial spectrum and is widely used to prevent and control various infections in humans and animals. CFX is a zoonotic drug, and its drug residues are more harmful to human health through the food chain, which is not conducive to the treatment of human diseases. In view of the importance of monitoring CFX residues in food of animal origin, it is of great significance to develop new methods for antibiotic detection with high sensitivity and selectivity. [0003] In recent years, scientists' in-depth research in the field of antibiotic detection technology has led...

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Problems solved by technology

[0007] (1) In the existing antibiotic detection methods, ECL reagents are usually highly toxic, difficult to functionalize and sensitive to the environment, which limits their wide application in ECL sensors

[0008] (2) There are few studies on the development of aggregation-induced electrochemiluminescent materials (AIECL) based on the AIE strategy

[0009] (3) The synthesis method of the existing COF-AIECL material is complicated, and the stability of the corresponding broken bond in the synthesis of the Schiff base chemical reaction is poor, which will affect the chemical reaction material

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