Antibacterial oxygen-releasing functional gel dressing as well as preparation and application thereof

Abstract

The invention discloses an antibacterial oxygen-releasing functional gel dressing as well as preparation and application thereof. The chitosan-polyethylene glycol-pyrogallol gel dressing is prepared through oxidation crosslinking of chitosan-hydrogenated caffeic acid and four-arm polyethylene glycol-pyrogallol, and the tissue adhesive force, the mechanical performance and the antibacterial capacity of the dressing can be remarkably improved; the delta-MnO2 nano-enzyme is uniformly loaded into the dressing, so that ROS (reactive oxygen species) generated at the wound of diabetes mellitus can be removed, oxidative stress of cells is eliminated, and oxygen can be continuously released. The gel dressing prepared by the invention has injectability, good mechanical properties (strong tensile property and compression property), strong tissue adhesion and antibacterial property, and has strong tissue adhesion and good stretchability, so that the gel dressing can be better attached to a wound, especially a joint part; the material can be used as a novel biological material in the biological fields of cells, tissue engineering, drug delivery and the like.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to an antibacterial and oxygen-releasing functional gel dressing and its preparation and application. Background technique [0002] The normal wound healing process can occur through various cellular responses, including activation of keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets. The pathological environment of diabetic wounds is significantly different from that of normal skin wounds. The oxidative microenvironment and high blood sugar environment at the wounds seriously hinder the healing process of diabetic skin wounds. In diabetic wounds, immune cells including neutrophils (leukocytes) will produce a large amount of reactive oxygen species (ROS) in a hyperglycemic environment, and the increase in ROS levels will cause wound cells to be damaged and the wound cannot be healed . High blood sugar can easily lead to bacterial infection in th...

AI Technical Summary

Problems solved by technology

It has been studied before that chitosan material modified by catechol can be oxidized into gel and have certain tissue adhesion, but the material has limited mechanical properties and does not have good antibacterial properties.

[0005] Although some synthetic gel dressings have been reported in the field of diabetic wound repair, the preparation technology of composite hydrogel dressings with injectability, strong tissue adhesion, strong antibacterial properties, ROS scavenging and continuous oxygen release has not been reported yet.

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