Sperm activity detection system and method based on micro-fluidic chip composite smart phone

A technology of microfluidic chips and smart phones, which is applied in measurement devices, material analysis by optical means, instruments, etc., to avoid low sperm motility, convenient detection process, and high accuracy.

Pending Publication Date: 2022-03-22
JIANGSU UNIV
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Problems solved by technology

[0003] The purpose of the present invention is to solve the problems existing in the existing sperm detection, provide a sperm motility detection system and method based on a microfluidic chip composite smart phone, improve the convenience of the sperm motility detection process and the accuracy of the detection results

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Embodiment Construction

[0031] see figure 1 , figure 2 with Figure 4 , the sperm activity detection system based on the microfluidic chip composite smart phone of the present invention is mainly composed of an upper plastic plate 10 and a lower plastic plate 11, the upper plastic plate 10 is above the lower plastic plate 11, and the upper plastic plate 10 is on both sides Extend the buckle 15 downwards, the two sides of the lower plastic plate 11 are upwardly provided with slots 14, the buckle 15 can be inserted in the slot 14 just in time, so that the upper plastic plate 10 passes through the slot 14 and the lower plastic plate 11. Buckles 15 are slidably connected together. The upper plastic plate 10 can be opened by sliding the buckle 15 during use.

[0032] The upper surface of the lower plastic plate 11 has a microfluidic chip placement groove 13, and the notch of the microfluidic chip placement groove 13 opens upwards, near the ends of the slots 14 on both sides (i.e. figure 1 Center near...

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Abstract

The invention discloses a sperm activity detection system and method based on a micro-fluidic chip composite smart phone in the field of biological activity detection, semen to be detected is injected into a first liquid inlet, sperm activity liquid is injected into a second liquid inlet, a camera of the smart phone collects and processes sperm images in a first semen pool, and the number of sperms is obtained; rotating the micro-fluidic chip by 180 degrees to record a sperm video of the second sperm pool and processing the sperm video frame by frame to obtain centroid coordinates and movement tracks of all sperms, fitting the movement track of each sperm to obtain an average movement path of the sperms, then calculating a curve path and a linear path of the movement track of each sperm to obtain six sperm kinematics parameters, and calculating the kinematics parameters of the sperms. The sperms are divided into four activity grades according to the parameters, and the sperm activity is judged according to the number of the four sperms and the number of the sperms in the first sperm pool; the micro-fluidic chip for simulating the fallopian tube is adopted, the sperm activity is analyzed by the smart phone, and the detection process is convenient, rapid and high in accuracy.

Description

technical field [0001] The invention relates to the field of biological activity detection, in particular to a sperm activity detection technology, which uses a microfluidic chip and a smart phone to detect the sperm activity. Background technique [0002] In the process of biological reproduction, the quality of sperm activity directly affects the success rate of breeding. Therefore, the detection of sperm activity is particularly important. The traditional sperm detection method is to stain the sperm in the semen with a staining reagent, and use a microscope to observe manually to judge the sperm activity. This method is cumbersome and relies on a large-scale microscope, so it can only be done in the laboratory. Moreover, manual observation is highly subjective and lacks rigorous and objective data support. With the rapid development of computer vision, many methods for detecting sperm activity using computer vision have emerged. For example, the Chinese patent applicatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84G01N21/01
CPCG01N21/84G01N21/01G01N2021/0112
Inventor 王天宝尹杭杨宁潘孝青张晓东张伏
Owner JIANGSU UNIV
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