Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Modified succinyl chitosan, drug-loaded nanoparticles and their application in the preparation of drugs targeting liver cancer cells

A technology of succinyl chitosan and drug-loading nanometers, which is applied in the directions of nano-drugs, drug combinations, drug delivery, etc., can solve the problem that succinyl can not effectively satisfy chitosan and other problems, and achieve the effect of high-efficiency encapsulation

Active Publication Date: 2022-08-02
GUANGXI MEDICAL UNIVERSITY
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the modification of the succinyl group cannot effectively meet the needs of chitosan as a drug carrier, such as how to improve its encapsulation effect, targeting effect, and release effect on drugs as a drug carrier.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Modified succinyl chitosan, drug-loaded nanoparticles and their application in the preparation of drugs targeting liver cancer cells
  • Modified succinyl chitosan, drug-loaded nanoparticles and their application in the preparation of drugs targeting liver cancer cells
  • Modified succinyl chitosan, drug-loaded nanoparticles and their application in the preparation of drugs targeting liver cancer cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] In order to make the purpose, technical solutions and advantages of the present application more clear, the present application will be further described in detail below with reference to the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application, but not to limit the present application.

[0032] Synthesis of Modified Succinyl Chitosan

[0033] 1. Degradation and deacetylation of chitosan

[0034] A specific implementation process of degradation and deacetylation is as follows: Weigh 5.0 g of chitosan (food grade chitosan, 150,000 to 300,000 molecular weight, degree of deacetylation ≧70%, Nanjing Ximeinuo Biotechnology Co., Ltd.) Add in 500mL 1% formic acid solution, stir to dissolve and filter, carry out oxidation reaction in the filtrate according to 5wt% of chitosan weight and 10wt% hydrogen peroxide solution, and feed ozone into the reaction solution at the same time, and the flow rate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present application discloses modified succinyl chitosan, drug-loaded nanoparticles and their application in preparing drugs targeting liver cancer cells. The modified succinyl chitosan has the molecular structure shown in formulas II to XI. By introducing a long-chain alkyl group and an amino acid with dihydroxyl groups at the same time, the prepared modified succinyl chitosan has both hydrophilic and hydrophobic properties, thereby showing efficient encapsulation of sorafenib, And it is beneficial to its slow release and thermal stability. In addition, this application also confirmed the targeting of the drug-loaded nanoparticles prepared from this type of modified succinyl chitosan to liver cancer cells through in vitro cell experiments and in vivo experiments in liver cancer tumor-bearing mice, and can effectively reduce tumor-bearing The tumor volume of mouse liver plays a real anti-tumor effect.

Description

technical field [0001] The present application relates to the technical field of modified chitosan, in particular to modified succinyl chitosan, drug-loaded nanoparticles and their application in preparing drugs targeting liver cancer cells. Background technique [0002] Chitosan and its derivatives have the advantages of non-toxicity, good biocompatibility and biodegradability, and long retention time in the body. In recent years, they have been widely used in the research of polymer drug carriers in the field of medicine. Since the side chain of chitosan has amino groups, it can react with succinic anhydride, and the introduction of a carboxyl group at the N-terminus of the glucosamine unit is expected to be effective for the performance of chitosan. [0003] However, the transformation of succinyl group cannot effectively meet the needs of chitosan as a drug carrier, such as how to improve its encapsulation effect, targeting effect, and release effect as a drug carrier fo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08A61K9/52A61K47/36A61K31/44A61P35/00B82Y5/00B82Y40/00
Inventor 唐博赵樑刘晓萌
Owner GUANGXI MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com