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Nano-palladium sheet loaded tuzumab nano-complex, preparation method and application of nano-palladium sheet loaded tuzumab nano-complex in preparation of medicine for treating inflammation-related anemia

A nano-composite, tocilizumab technology, applied in the direction of nano-drugs, antibodies, anti-inflammatory agents, etc., can solve the problems of side effects, reduce the effective drug concentration of the target organ liver tissue, etc., to reduce side effects, increase the effective drug concentration, Improve the effect of AI action

Pending Publication Date: 2022-04-22
天津市泌尿外科研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after TCZ enters the body through the blood, it will be distributed to the tissues and organs of the whole body, which reduces the effective drug concentration in the liver tissue of the target organ, and also induces side effects of other tissues and organs throughout the body.

Method used

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  • Nano-palladium sheet loaded tuzumab nano-complex, preparation method and application of nano-palladium sheet loaded tuzumab nano-complex in preparation of medicine for treating inflammation-related anemia
  • Nano-palladium sheet loaded tuzumab nano-complex, preparation method and application of nano-palladium sheet loaded tuzumab nano-complex in preparation of medicine for treating inflammation-related anemia
  • Nano-palladium sheet loaded tuzumab nano-complex, preparation method and application of nano-palladium sheet loaded tuzumab nano-complex in preparation of medicine for treating inflammation-related anemia

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Experimental program
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Embodiment Construction

[0023] 1. Preparation of Palladium Nanosheets (PdPL)

[0024] Add 10 mg of palladium(II) acetylacetonate, 30 mg of polyvinyl pyrrolidone (Polyvinyl pyrrolidone, PVP) and 10 mg of sodium bromide into a glass pressure reactor, add 2 mL of N,N-dimethylformamide (N,N-Dimethylformamide, DMP ) and mix well, add 4mL of double distilled water (Double distilled water, ddH 2 O) Mix well. Then use CO flow to exhaust the air in the container, so that the CO pressure in the container is maintained at 1 standard atmospheric pressure, place it in an oil bath with continuous stirring, and heat it from room temperature to 60 °C within 30 minutes. The reaction was continued for 1.5 hours and then cooled to room temperature. Add 37.5mg palladium acetylacetonate (II) to the container after the above reaction again and add it to the reaction container and make it fully dissolved. Use CO to empty the air in the container and maintain the CO pressure in the container at 1 standard atmosphere. It ...

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Abstract

The invention discloses a nano-palladium sheet loaded tuzumab nano-complex, a preparation method and application of the nano-palladium sheet loaded tuzumab nano-complex in preparation of drugs for treating inflammation-related anemia. According to the invention, the loading capacity of the PdPL on TCZ is improved in a manner of surface modification of the PdPL, so that the PdPL-PEG (at) TCZ nano-composite is constructed. According to the PdPL-PEG (at) TCZ nano-composite, the characteristic that PdPL passively targets liver tissues is utilized, TCZ is efficiently transported and enriched in the liver tissues, and IL-6 / IL-6R / JAK2 / STAT3 / Hepcidin signal channels of liver cells are blocked, so that the anemia degree of a mouse model is effectively improved, and meanwhile side effects induced by distribution of TCZ in other tissues can be reduced. The PdPL-PEG (at) TCZ nano-complex disclosed by the invention provides a new means for treating AI (Alzheimer's disease).

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a nano-palladium plate-loaded tocilizumab nanocomposite, a preparation method and its application in the preparation of drugs for treating inflammation-related anemia. Background technique [0002] The incidence of inflammation-associated anemia (Anemia of inflammation, AI) ranks second in the incidence of anemia in the world. AI is prevalent in patients with infectious diseases, autoimmune diseases, chronic kidney disease, congestive heart failure, and cancer, and patients with such diseases are usually accompanied by abnormal activation of the immune system. AI can adversely affect the physiological functions of multiple tissues and organs in patients, especially for patients who are receiving chemotherapy and / or radiotherapy, AI may accelerate their tumor progression. At the same time, studies have shown that in elderly patients (>60 years old), the presence of AI can signific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K47/02A61K47/10A61P29/00A61P7/06B82Y5/00B82Y40/00
CPCC07K16/2863A61K47/02A61K47/10A61P29/00A61P7/06B82Y5/00B82Y40/00A61K2039/505
Inventor 朱建强付青峰柳乐意郑志文
Owner 天津市泌尿外科研究所
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