277 results about "Cells signal" patented technology

The invention discloses an anti-aging composition containing ergothioneine, glutathione and fish collagen, relates to the technical field of anti-aging compositions, and aims to solve the technical problems that a traditional anti-aging composition lacks attention to the aspects of cell energy metabolism, barrier repair and the like, and the overall skin improvement effect is not obvious. The ergothioneine is used as a natural antioxidant, and the content of the ergothioneine is 0.01-5wt%; the ergothioneine participates in a synergistic effect of an intracellular antioxidant enzyme system, so that tyrosinase activity is effectively inhibited, melanogenesis is reduced, and DNA and protein are protected from oxidation damage; in a simulated strong ultraviolet environment, compared with skin cells not using the ergothioneine-containing product, the content of free radicals in the cells is reduced by 30% after the ergothioneine-containing product is used; the ergothioneine can also regulate a cell signal channel, promote cell metabolism and maintain normal growth of cells. The mask has the advantages of accelerating skin metabolism and improving the self-repairing ability of the skin.

The invention discloses a preparation method of an oral liver protection composition containing ergothioneine, and relates to the technical field of ergothioneine application. The oral liver protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.5 to 5 parts of the ergothioneine, 10 to 30 parts of silibinin, 20 to 50 parts of a phospholipid complex, 5 to 15 parts of a liver targeting carrier, 2 to 8 parts of a disintegrating agent, 1 to 5 parts of an adhesive and 2 to 4 parts of an antioxidant. Free radicals are efficiently captured through a polycyclic conjugated pi electron system of the antioxidant, a hydrogen bond network is formed by a heteroatom bridging effect of the antioxidant, a galactose group of the liver targeting carrier and the disintegrating agent, and the stability of the system is synergistically improved; the phospholipid complex is embedded with a hydrophobic drug and a hydrophilic carrier, and the drug is accurately delivered to the liver by combining the specific recognition capability of the liver targeting carrier; the ergothioneine and the silybin form a bidirectional synergistic liver protection mechanism by removing reactive oxygen free radicals and regulating and controlling cell signal channels respectively.

The invention discloses a prediction method for identifying a protein-protein interaction site. According to the method, a deep learning framework is constructed based on protein chain hierarchical graph construction and double-branch graph neural network learning. The method comprises the following steps: firstly, constructing a corresponding hierarchical graph for each protein chain, including a residue-level graph and an atomic-level graph; next, the method constructs an isotropic graph neural network (EGNN) module to extract residue-level embedding with isotropic features. After a GraphSAGE module is further used for extracting atomic-scale embedding, the method integrates layered graph features by using a comparative learning strategy so as to learn residue-scale and atomic-scale consistency embedding. Finally, an improved gated multi-head attention mechanism is used for fusion embedding weighting, and residue-level interaction classification prediction is performed through a multi-layer perceptron. A comprehensive evaluation result on a plurality of data sets shows that the method is remarkably superior to an existing method. In conclusion, according to the method, various advanced technologies such as graph structure denaturation, multi-scale modeling and comparative learning are fused, and an accurate and steady solution with expansion potential is provided for protein interaction prediction. The method can assist researchers in deeply recognizing key protein acting sites and promoting analysis work of cell signal channels and metabolic networks.

The invention relates to the technical field of food, medicine and health care products, and discloses a composition containing rosemary exosome vesicles and application of the composition in anti-inflammatory, the composition is formed by mixing plant cell-derived exosome vesicles and functional active ingredients, the composition comprises the following components in percentage by mass: 45-55% of rosemary exosome and 45-55% of turmeric exosome; the preparation method of the composition containing the rosemary exosome vesicles comprises the following steps: S1, taking a certain amount of fresh rosemary and turmeric plants, removing root hairs and impurities, washing the fresh plants with domestic drinking water, washing the fresh plants with purified water for three times, and finally washing the fresh plants with ultrapure water for three times for 3-5 minutes each time; the product can carry various bioactive molecules, transfer cell signals in a transboundary manner, participate in anti-inflammation, inhibit tumor cell proliferation and promote normal tissue repair, has an anti-inflammatory effect, inhibits release of inflammatory factors, improves the immune function of a body and adjusts the immune balance state, and can play a role in neovascularization diseases of the body.

The present invention provides a real-time flow cytometric analyzer of single-cell dynamics combining droplet microfluidics and multimodal optical microscopy, and belongs to the field of cell biology experimental devices. The analyzer comprises a cell / signal loading & acquisition and control system, a high-throughput microfluidic single-cell manipulation chip, a multi-channel optical microscopy and multimodal signal acquisition and control system, and a data processing and analysis system. Based on droplet-based microfluidic chip technology, multimodal optical microscopy technology, single-cell dynamics theoretical modeling and analysis methods, and artificial intelligence technology, the integrated detection of spatiotemporal information of single-cell dynamics can be realized. The analyzer provides a new rapid and accurate single-cell dynamics analysis platform for exploring the occurrence and development mechanism of major human diseases, disease diagnosis, cell sorting and drug screening, etc.

The present disclosure relates generally to compositions and methods for improving T cell therapy. In particular, the disclosure provides polypeptides and recombinant nucleic acid constructs and / or recombinant nucleic acids encoding polypeptides having mutations capable of effecting altering T cell signaling, cytokine production, and / or in vivo persistence of therapeutic T cells comprising the mutations in tumors. The T cell signaling may be carried out by the NFAT, NF-[kappa] B, and / or AP-1 pathway. The disclosure also provides vectors and cells comprising the polypeptides and / or recombinant nucleic acid constructs and / or recombinant nucleic acids of the disclosure, as well as methods of making T cells for use in cell therapy, and methods of identifying mutations useful for improving T cell therapy.

The utility model provides a CCS thermal safety combination device for all-cell signal acquisition, which comprises a plastic uptake isolation plate used for being electrically connected with a battery assembly, the plastic uptake isolation plate is provided with a cell area and positioning areas, and the positioning areas are arranged on two opposite sides of the cell area; the FPC is mounted in the battery cell area and is electrically connected with the blister isolation plate; the fireproof sheet is arranged corresponding to the FPC and the blister isolation plate so as to cover the surface of the FPC and the surface of the blister isolation plate; and the insulating sheet covers the fireproof sheet and is fixedly connected with the blister isolation plate. The fireproof sheet is placed on the FPC to avoid the battery cell explosion-proof valve, and the whole insulating sheet is placed at the top end of the fireproof sheet, so that the battery cell can be effectively protected, heat spreading during thermal runaway of the battery cell is prevented, the risk of thermal runaway of the battery cell is reduced, and the maintenance and replacement cost of the battery is reduced.

The invention provides a communication method, device and system, a computer program product and a readable storage medium, and the method can be applied to a communication scene exemplarily. In the method, a terminal device receives a first measurement event and a second measurement event configured by a source access network device, and takes the first measurement event and the second measurement event related to estimated service time as execution conditions. The terminal device can select the target cell according to the estimated service time of the candidate cell and the estimated service time of the source cell to perform cell switching. Compared with the existing scheme that the target cell is selected only according to the cell signal quality, the terminal equipment can execute cell switching under the condition that the first measurement event and the second measurement event are triggered, and the terminal equipment can perform cell switching under the condition that the estimated service time of the source cell is short and the estimated service time of the candidate cell is relatively long. And switching to the target cell capable of providing relatively long service time, thereby reducing the frequency of switching the access network equipment by the terminal equipment, and improving the communication stability.

The present application belongs to the technical field of communications. Disclosed are a cell measurement method, a communication apparatus, a storage medium and a computer program product. In the present application, a target time offset may indicate a time offset between a measurement window of a neighbor cell measurement signal and a serving cell signal, so that a terminal may directly determine the measurement window of the neighbor cell measurement signal according to the target time offset, and then uses a low-power receiver to measure within the measurement window the neighbor cell measurement signal, thus implementing cell measurement when the terminal in a low-power state. In the embodiments of the present application, as the terminal may directly determine measurement timing of the neighbor cell measurement signal according to the target time offset, and determine the measurement timing without relying on frame number information, the neighbor cell measurement signal may not carry the frame number information. In this way, the present application may reduce the bit overhead of neighbor cell measurement signals, thus better supporting low-power receivers to perform cell measurement.

The invention relates to the technical field of biology, and discloses a method for constructing immortalized thymoma primary epithelial cells. The method comprises the following steps: step 1, tissue dissociation and mixed cell population acquisition; step 2, performing differential liquid change to remove immune cells; step 3, immortalization treatment; step 4, carrying out monoclonal screening; step 5, amplification and verification; and step 6, passage and storage. The method is mainly used for establishing a stable immortalized cell line in a laboratory for subsequent scientific research. The specific application comprises tumor biology research; anti-tumor drug screening; cancer-related gene function research; and cell signal transduction mechanism research and the like. For tumors which do not have mature cell lines or are difficult to establish primary cell lines, such as thymoma, the invention is beneficial to improving the success rate of establishing immortalized tumor primary cell lines and promoting the development of subsequent basic scientific research.

Disclosed herein are cell signaling complexes such as chimeric cytokine complexes and uses thereof. In some embodiments, a chimeric cytokine complex comprises a protein cage polypeptide, a plurality of engineered Fc antibody domains bound to the protein cage polypeptide, and one or more cytokines linked to each of the plurality of engineered Fc antibody domains. Also disclosed are Fc-cytokine complexes and uses thereof. In some embodiments, an Fc-cytokine complex comprises an engineered Fc antibody domain and one or more cytokines linked to the engineered Fc antibody domain.

An embodiment of the invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for FLT3, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.

The invention discloses an infrared polarization detector and device, and relates to the photoelectric detection technology. The detector chip (2) is electrically connected with the reading circuit (1) through an indium column (5), a polarization grating (4) is arranged on one surface, far away from the reading circuit (1), of the detector chip, and a pixel array structure (3) is arranged on the other surface, close to the reading circuit (1), of the detector chip; the relative positions of the pixel array structures (3) and the polarization gratings (4) are in one-to-one correspondence. Through the design of the n-type region of the polarization grating structure, the crosstalk of adjacent pixel signals can be blocked, so that the response value when the light transmission axes of the polarizer and the polarization grating are vertical is reduced, and the extinction ratio of the infrared polarization detector is improved.

Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in immune cells, antibodies binding to a set of amino acid residues required for its ligand binding, and uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

The present disclosure provides a neighboring cell measurement method, comprising: receiving SMTC information; and determining an SMTC window according to a positioning capability of a terminal device and the SMTC information, the SMTC window being used to perform a neighboring cell measurement. In this way, a terminal device having positioning capabilities meeting the requirement can more accurately determine a neighboring-cell signal delay on the basis of its own positioning capabilities, without having to extend an SMTC window to eliminate the impact of signal delay calculation errors.

The invention discloses a culture method for improving proliferation and differentiation capacity of NK (Natural Killer) cells based on angelica sinensis-astragalus membranaceus exosomes, which comprises the following steps: firstly extracting exosomes in angelica sinensis and astragalus membranaceus, then adding the exosomes into an NK cell culture system according to a specific concentration, and regulating and controlling an NK cell signal channel by virtue of active ingredients carried by the exosomes so as to improve the proliferation and differentiation capacity of the NK cells. Therefore, the proliferation rate and differentiation maturity of the NK cells are remarkably improved. Experimental results show that compared with a traditional culture method, the proliferation multiple of the NK cells cultured through the method is increased by 28.99%-33.69%, the proportion of differentiated mature cells is increased by 15.91%-28.30%, and the cell killing activity is not remarkably reduced. The method can be widely applied to the field of immune cell treatment, provides a high-quality NK cell source for clinic, effectively solves the problems of slow cell proliferation rate, low differentiation maturity, easy activity reduction after large-scale culture and the like in traditional NK cell in-vitro culture, and has important clinical application value and industrialization prospect.

Disclosed herein are cell signaling complexes such as chimeric cytokine complexes and uses thereof. In some embodiments, a chimeric cytokine complex comprises a protein cage polypeptide, a plurality of engineered Fc antibody domains bound to the protein cage polypeptide, and one or more cytokines linked to each of the plurality of engineered Fc antibody domains. Also disclosed are Fc-cytokine complexes and uses thereof. In some embodiments, an Fc-cytokine complex comprises an engineered Fc antibody domain and one or more cytokines linked to the engineered Fc antibody domain.

An example method for estimating a number of individuals present in a crowd includes generating a density map based on an image of a crowd, using a convolutional neural network, augmenting the density map with cellular signal processing data to produce an augmented density map, and estimating a number of individuals present in the crowd, based on the augmented density map.

The invention discloses a cell energy-saving optimization method and device, a readable storage medium and a program product. The method comprises the following steps: acquiring a plurality of characteristics influencing cell signal propagation of a target area; on the basis of the obtained characteristics influencing the signal propagation of the cells and a path loss model, predicting the signal strength and load of each opened cell in the target area after the target cell in the target area executes the closing of the energy-saving strategy; the path loss model is obtained through training by taking the characteristics influencing the signal propagation of the cell as samples and taking antenna transmitting power loss generated on a signal propagation path by a cell corresponding to the characteristics influencing the signal propagation of the cell as labels; based on the predicted signal strength and load, determining an optimization strategy of each open cell, the optimization strategy comprising adjusting antenna parameters of the corresponding open cell; and after the target cell is closed according to the energy-saving strategy, adjusting the antenna parameters of the corresponding open cell according to the optimization strategy.

The invention discloses a prediction method, a terminal and network side equipment, and belongs to the technical field of communication, and the prediction method comprises the steps that the terminal obtains a first parameter; and the terminal determines whether to predict the signal quality of the cell based on the first parameter to obtain a predicted value.

Embodiments of this application provide a method for measuring signal quality of a cell, and a related apparatus. The method includes: receiving a measurement configuration from a network device, where the measurement configuration includes a trigger beam quantity, and the trigger beam quantity is a beam quantity threshold that triggers generation of a cell measurement result; determining that a quantity of detected beams is greater than or equal to the trigger beam quantity, where the detected beams belong to one or more cells; and obtaining a cell measurement result for the one or more cells based on signal quality of the detected beams. According to embodiments of this application, a frequency of reporting a measurement report can be decreased, reducing communication overheads.

A spectroscopic bioagent detection apparatus and method are provided. In one aspect, an optical detection system and method are used to identify and / or detect a virus or bacteria by using a microscope and measuring vibrational motion or phonons of the virus or bacteria. A further aspect of the present apparatus and method include automatically optically measuring vibrational motion or phonons of a target virus or bacteria, substantially in real-time, in vivo or in situ, automatically filtering out undesired background and living cell signals, and automatically identifying a characteristic of the virus or bacteria.

A system for treating various medical conditions in humans includes a medical or therapeutic laser operating at wavelengths in the near infrared range of between 1250 nm-1267 nm, with a target wavelength of 1260 nm, at power levels between 2 Watts and 60 Watts, and for a period not to exceed 60 seconds per dose. The emitted laser light energizes, e.g., the stem cell niche or mitochondria of the human tissue to which it is applied, both directly and indirectly via activation of cell signaling intermediaries including but not limited to heat shock proteins, thereby stimulating cell activity to promote healing and reduce pain. In this specific wavelength range, water absorption of the laser light energy is plateaued which effectively acts as a conduit allowing the laser light energy to be transferred deeper into the tissue without causing thermal damage to the skin and tissue.

The invention discloses a scene recognition method and apparatus, a device and a storage medium. The method comprises the steps of obtaining first real-time information; wherein the first real-time information at least comprises one or more of the following items: sensor information; cell number change information; cell signal intensity change information; searching information by a satellite; a cell monitoring result; and performing scene recognition of the basement scene based on the first real-time information to obtain a scene recognition result.

A method for selectively targeting tumor cells for a given strain of cancer includes providing amino acids shown to discourage promotion of tumor growth for the given strain of cancer. The method may include determining the amino acids by identifying extracellular vesicles (EVs) involved in cell-cell signaling for tumor development, quantifying relative abundance of amino acids present in patient samples, comparing the relative abundance of the amino acids from the patient sample to a known distribution of the individual amino acids present in a nonmalignant sample, and comparing the abundance of the amino acids in the patient sample to the nonmalignant sample to determine the plurality of amino acids suitable for treating the given strain of cancer. The method may include supplementing the combination of the plurality of amino acids with a chemotherapy drug.

A touch controller is used to control a touch panel. The touch panel has an array of sensor cells divided in to N columns, each column has M regions, M regions are grouped into P zones. The touch controller has a switch circuit and a sensing circuit. In a coarse scan period, the switch circuit shorts the sensor cells in each zone of each column, and the sensing circuits scans P×N zones of the N columns to generate P×N zone signals. In M fine scan periods, the switch circuit decouples the sensor cells in a triggered zone of the P×N zones, and the sensing circuit scans a region of the triggered zone without scanning untriggered zones of the P×N zones to generated cell signals.

The wireless device performs an uplink transmission, such as an idle mode uplink transmission using a preconfigured uplink resource (PUR). The wireless device determines whether the serving cell signal measurement M2 has been completed within a predetermined time range before the reference time T2, where the reference time T2 corresponds to an uplink transmission opportunity. In response to determining that the serving cell signal measurement M2 has not been completed within the predetermined time range, the wireless device defers the transmission to a subsequent transmission opportunity, or abandons the uplink transmission, or collects additional serving cell measurements M2' that fall within the predetermined time range for verifying the TA used for transmission at the uplink transmission opportunity and / or estimating the PL for power control of the transmission at the uplink transmission opportunity.

The present invention discloses an improved c-Met neutralizing antibody and a preparation method and application thereof. It belongs to the field of biopharmaceutical technology. The present invention optimizes the structure and activity of an agonistic c-Met antibody with neutralizing activity through a random mutation library of antibodies and cell display technology, obtains an antibody with high affinity and low agonistic activity, and maintains the neutralization and internalization activity of the parent antibody, thereby improving the drugability of the c-Met antibody. The obtained mutant antibody 2G5 has a good purification effect, an IC50 of 41.53ng / ml, and a strong ability to bind to the extracellular region of c-Met. The results of the blocking ELISA experiment showed that the mutant antibody 2G5 had significant neutralizing activity, and in A549 cells, the antibody caused a significant internalization effect. The mutant antibody 2G5 could not activate the c-Met signaling pathway of A549 cells, and could not cause HUVEC cell proliferation and A549 cell migration. A mutant antibody with higher drugability was obtained.

This disclosure provides systems, methods and apparatus for cellular communications. In one aspect, a UE determines an FFP of a cell signal for the UE in a frame based equipment mode, determines one or more SSB positions in the cell signal based on the FFP, and performs radio management of the UE based at least in part on the one or more invalid SSB candidate positions. Performing radio management may include using one or more SSB positions in the FFP exclusive of the one or more invalid SSB candidate positions. Radio management may include PDSCH rate matching, radio link monitoring or measurement, or radio resource management. In some implementations, the one or more SSB positions are SSB positions after a first eight SSB positions in an FFP. In some other implementations, the one or more SSB positions are SSB positions that at least partially overlap an idle period between FFPs.

The invention relates to a communication method, a terminal, network equipment, a communication system and a storage medium. The communication method comprises the following steps that: a response terminal is in a non-connection state, the terminal measures the signal quality of a cell in a DRX (discontinuous reception) opening time period in N DRX periods, N is smaller than or equal to M, and M is the number of the DRX periods used for evaluating the quality of received signals of the cell. Through the embodiment of the invention, the power consumption of the terminal can be reduced.