105 results about "Cells signal" patented technology

The invention discloses a culture method for improving proliferation and differentiation capacity of NK (Natural Killer) cells based on angelica sinensis-astragalus membranaceus exosomes, which comprises the following steps: firstly extracting exosomes in angelica sinensis and astragalus membranaceus, then adding the exosomes into an NK cell culture system according to a specific concentration, and regulating and controlling an NK cell signal channel by virtue of active ingredients carried by the exosomes so as to improve the proliferation and differentiation capacity of the NK cells. Therefore, the proliferation rate and differentiation maturity of the NK cells are remarkably improved. Experimental results show that compared with a traditional culture method, the proliferation multiple of the NK cells cultured through the method is increased by 28.99%-33.69%, the proportion of differentiated mature cells is increased by 15.91%-28.30%, and the cell killing activity is not remarkably reduced. The method can be widely applied to the field of immune cell treatment, provides a high-quality NK cell source for clinic, effectively solves the problems of slow cell proliferation rate, low differentiation maturity, easy activity reduction after large-scale culture and the like in traditional NK cell in-vitro culture, and has important clinical application value and industrialization prospect.

A spectroscopic bioagent detection apparatus and method are provided. In one aspect, an optical detection system and method are used to identify and / or detect a virus or bacteria by using a microscope and measuring vibrational motion or phonons of the virus or bacteria. A further aspect of the present apparatus and method include automatically optically measuring vibrational motion or phonons of a target virus or bacteria, substantially in real-time, in vivo or in situ, automatically filtering out undesired background and living cell signals, and automatically identifying a characteristic of the virus or bacteria.

A touch controller is used to control a touch panel. The touch panel has an array of sensor cells divided in to N columns, each column has M regions, M regions are grouped into P zones. The touch controller has a switch circuit and a sensing circuit. In a coarse scan period, the switch circuit shorts the sensor cells in each zone of each column, and the sensing circuits scans P×N zones of the N columns to generate P×N zone signals. In M fine scan periods, the switch circuit decouples the sensor cells in a triggered zone of the P×N zones, and the sensing circuit scans a region of the triggered zone without scanning untriggered zones of the P×N zones to generated cell signals.

The invention relates to a communication method, a terminal, network equipment, a communication system and a storage medium. The communication method comprises the following steps that: a response terminal is in a non-connection state, the terminal measures the signal quality of a cell in a DRX (discontinuous reception) opening time period in N DRX periods, N is smaller than or equal to M, and M is the number of the DRX periods used for evaluating the quality of received signals of the cell. Through the embodiment of the invention, the power consumption of the terminal can be reduced.

The present disclosure relates to a primary secondary cell processing method, a terminal and a computer storage medium, and relates to the technical field of communication. The primary secondary cell processing method is executed by a terminal, and includes: obtaining, from a primary base station, configuration information of at least one candidate primary secondary cell corresponding to a non-ground access network-based secondary base station and a required trigger condition for switching, the candidate primary secondary cell has an overlapping area with a primary cell of the primary base station, and the trigger condition includes at least one of a time condition and a location condition, and a cell signal quality condition; judging whether each candidate primary secondary cell meets the corresponding trigger condition; in the case that at least one candidate primary secondary cell meets the corresponding trigger condition, selecting a target primary secondary cell from the at least one candidate primary secondary cell; and accessing the target primary secondary cell according to the configuration information of the target primary secondary cell.

This disclosure provides a method for determining the beam failure detection (BFD) relaxation state, wherein the method is executed by a terminal, and the method includes: in a multiple transmit / receive node (mTRP) scenario, determining whether the terminal is in a relaxation state based on predetermined rules; wherein the relaxation state is a state in which the terminal can perform BFD relaxation; the predetermined rules include at least one of the following: a low mobility criterion; and a good cell signal quality criterion. Here, in the mTRP scenario, the terminal's presence or absence in the relaxation state can be determined based on the low mobility criterion and / or the good cell signal quality criterion. Compared to situations where it cannot be clearly determined whether the terminal is in or not in a relaxation state, BFD relaxation can be performed based on the determination result, improving the reliability of wireless network communication.

The invention relates to an expression line resisting composition containing cell signal factors and plant active ingredients and a skin care product of the expression line resisting composition. The expression line resisting composition is prepared from the following components in percentage by mass: 10 to 50 percent of cell signal factors, 10 to 50 percent of flos chrysanthemi extract and 10 to 50 percent of camellia seed oil. By adopting a composite strategy of metabolism regulation and neuromuscular regulation, nerve-muscular signal conduction is regulated, facial muscle tension is weakened, and dynamic formation of expression lines is reduced; the AMPK energy metabolism pathway is activated, and the cell activity is improved; rOS accumulation in cells is reduced, and the mitochondrial function is improved; strong fat-soluble anti-oxidation protection is provided, the action time is prolonged, barrier repair, moistening and anti-inflammation are facilitated, and therefore the more efficient expression line resisting effect is achieved.

To provide agents for modulating cell signaling and / or cellular activities.SOLUTION: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and / or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.SELECTED DRAWING: Figure 3

The present application relates to compositions comprising fusion proteins and cells expressing the proteins. The application further relates to methods of using the fusion proteins, cells, and compositions for modulating cell signaling and for selective expansion of cells.

A touch controller is disclosed for controlling a touch panel. The touch panel includes an array of a plurality of sensing units, the plurality of sensing units are divided into N columns, each column includes M ranges, and the M ranges in each column are grouped into P regions. The touch controller includes a switching circuit and a sensing circuit. During a coarse scan, the switching circuit couples the plurality of sensing units in each region of each column to each other, and the sensing circuit scans the P x N regions of the N columns to generate P x N region signals. During M fine scans, the switching circuit uncouples the plurality of sensing units in a triggered region of the P x N regions from each other, and the sensing circuit scans the ranges in the triggered region without scanning the plurality of untriggered regions of the P x N regions to generate a plurality of cell signals of the plurality of sensing units in the triggered region.

The invention discloses a battery pack monitoring system and method based on a built-in sensor, the battery pack comprises a plurality of battery cells, the system comprises a plurality of battery cell internal monitoring assemblies, a module data acquisition unit and a monitoring terminal, the battery cell internal monitoring assemblies are packaged in the battery cells, and the module data acquisition unit is connected with the monitoring terminal. The module data acquisition unit is respectively in wired connection with the plurality of battery cell internal monitoring assemblies, and the monitoring terminal is in wireless or wired communication with the module data acquisition unit; the cell internal monitoring assembly comprises a miniature PCB, a pressure sensor, a temperature sensor and a signal terminal, and the pressure sensor and the temperature sensor are integrated on the miniature PCB; the signal terminal is arranged on a cover plate of the battery cell, and the signal terminal comprises a battery cell positive pole, a battery cell negative pole and a signal line pole. According to the system and the method, the problems of large external monitoring error, unreliable wireless transmission, sealing failure of wired transmission, multi-cell signal interference and the like in the prior art are solved.

The application relates to the field of cell signal detection, in particular to a multi-size microelectrode array detection device coupled with microelectroporation and a preparation method thereof. The multi-size microelectrode array detection device comprises a first microelectrode array device, a second microelectrode array device, and an electrophysiological signal acquisition module. The first microelectrode array device comprises a first chip, a first printed circuit board and a first cell culture chamber, and the first chip comprises a plurality of microelectrodes with mixed sizes. The second microelectrode array device comprises a second chip, a second printed circuit board and a second cell culture chamber, and the second chip comprises a plurality of microelectrodes with the same size. The microelectrodes on the second chip of different second microelectrode array devices are not the same in size. The electrophysiological signal acquisition module collects the electrophysiological signals of cells collected by the first microelectrode array device and the second microelectrode array device. An upper computer stores and displays the electrophysiological signal data collected by the electrophysiological signal acquisition module. The application improves the adaptability of the cell detection device and the accuracy of the cell electrophysiological signal detection result.

1. The name of the design product: multifunctional enzyme label instrument. 2. The use of the design product: for nucleic acid, protein concentration, enzyme activity analysis and other conventional molecular detection; signal transduction research, cell signal event active oxygen, modification detection; cell viability, apoptosis, killing and other overall level analysis. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention describes a method to infer the Hippo cellular signaling pathway activity in a sample based on assessing the expression levels of six or more predefined target genes. The invention further describes the use of the method in prognostic and diagnostic applications and use of the method to determine or predict therapy resistance.

Antibodies that specifically bind to TrkB and methods for using the same are described. Neuroprotective agonist antibodies are described, as indicated by their effect on enhancing the survival of retinal ganglion cells in vitro, and these agonist antibodies may be used to treat eye disorders, such as glaucoma. Additionally, other neuronal diseases or disorders, including those characterized by partial neuronal damage, benefit from treatment using these agonist antibodies. In certain embodiments, the present invention comprises antibodies that bind to TrkB and mediate cell signaling. The antibodies of the present invention may be whole human, non-natural antibodies formulated as injectable excipients.

Antibodies that specifically bind to TrkB and methods of use thereof are disclosed. Agonist antibodies having neuroprotective effects, as shown by their ability to enhance retinal ganglion cell survival in vitro, are disclosed, and these agonist antibodies can be used in the treatment of conditions such as eye diseases, including glaucoma. In addition, other neuronal diseases or conditions can also benefit from treatment with these agonist antibodies, including those characterized in part by neuronal damage. In certain embodiments, the present invention includes antibodies that bind to TrkB and mediate cell signaling. The antibodies of the present invention can be fully human, non-naturally occurring antibodies formulated with an excipient for injection.

Disclosed herein are cell signaling complexes, such as chimeric cytokine complexes, and their uses. In some embodiments, the chimeric cytokine complex comprises a protein cage polypeptide, a plurality of engineered Fc antibody domains bound to the protein cage polypeptide, and one or more cytokines linked to each of the plurality of engineered Fc antibody domains. Also disclosed are Fc-cytokine complexes and their uses. In some embodiments, the Fc-cytokine complex comprises engineered Fc antibody domains and one or more cytokines linked to the engineered Fc antibody domains.

The present disclosure relates to compositions and methods for modulating signaling in a cell and / or for differentiating / maturing a cell. Compositions of this disclosure, as may be used in associated methods, may include first and second segments that are connected to one another. When used in methods to differentiate and / or mature immune cells, compositions of this disclosure advantageously increase frequency and yields of arising cells in comparison to conditions deploying only first or second segments separately, or both individually (not connected).

The present invention relates to a cosmetic composition for promoting skin regeneration, and more particularly, to a cosmetic composition for promoting skin regeneration by further comprising a polydeoxyribonucleotide (PDRN) in a composition comprising a sponge microneedle, a lactic acid bacteria exosome, and a ceramide in a specific weight ratio, and more particularly, to a cosmetic composition for promoting skin regeneration by adding a polydeoxyribonucleotide (PDRN) to a composition comprising a sponge microneedle, a lactic acid bacteria exosome, and a ceramide in a specific weight ratio. The sponge microneedle forms a microchannel in a skin cuticle to promote transmission of effective components, the lactic acid bacteria exosome induces cell viability through a cell signal transduction function, and the ceramide strengthens a skin barrier. By adding PDRN in the range of 0.001 to 3% by weight relative to the total weight of the composition, proliferation of skin fibroblasts, collagen synthesis and wound healing can be promoted. The composition can be prepared into various dosage forms such as face cream, emulsion, essence, ampoules or facial masks, and the improved skin regeneration effect is provided by simultaneously achieving the effects of strengthening the skin barrier, activating cells and promoting tissue regeneration.

A battery pack for use in an electric vehicle having two longitudinal sill members extending in a length direction, interconnected at a front side by front and rear transverse members, a number of rectangular battery cells being placed between the sill members, the front transverse member and the rear transverse member, the cells being mutually adjacent in the length direction. The battery pack has at least a chamber integrated in the rear transverse beam, said chamber being configured to accommodate an analog-to-digital converter.

The invention discloses a myocardial cell intracellular signal prediction method and related equipment, and the method comprises the steps: obtaining an extracellular physiological signal of a myocardial cell, carrying out the variational mode decomposition of the denoised extracellular physiological signal, and obtaining a plurality of components with different center frequencies; determining a high-frequency component feature and a low-frequency component feature according to the plurality of components with different center frequencies, inputting the high-frequency component feature into a trained first prediction model to obtain a high-frequency feature tensor, and inputting the low-frequency component feature into a trained second prediction model to obtain a low-frequency feature tensor; and performing space-time fusion on the high-frequency feature tensor and the low-frequency feature tensor to obtain an intracellular signal of the myocardial cell. According to the embodiment of the invention, the electrophysiological signal in the myocardial cell can be stably detected for a long time. The method can be widely applied to the technical field of cell signal measurement.

The application discloses application of an S1PR1 selective agonist SAR247799 in preparation of a drug for treating neuromyelitis optica spectrum disorders. The SAR247799 can up-regulate S1PR1 expression of astrocytes, activate an S1PR1 signal path of the astrocytes, inhibit AQP4-IgG and complement-mediated damage of the astrocytes, reduce loss of AQP4, GFAP and ALDH1L1 in a lesion area of brain tissue of a neuromyelitis optica spectrum disorder model mouse, and relieve pathological damage of the neuromyelitis optica spectrum disorder model. In-vivo and in-vitro experiments prove that the SAR247799 can effectively inhibit AQP4-IgG and complement-dependent cytotoxicity effects and promote survival of the astrocytes. The application provides a novel, efficient and specific targeted drug for clinical treatment of the neuromyelitis optica spectrum disorder.

The application provides application of a small molecule compound YZL-51N in preparation of a SIRT7 selective inhibitor. The application finds that the small molecule compound YZL-51N can be used as a specific small molecule inhibitor of SIRT7. The application verifies that the compound YZL-51N can effectively inhibit SIRT7 deacetylase activity by using polypeptide deacetylation. The application also proves that YZL-51N has stronger interaction affinity with SIRT7 compared with other sirtuins family members by a BLI experiment method. The application verifies that the small molecule compound inserts into a pocket and interacts with hot spot amino acids by a molecular docking experiment. In a cell model, YZL-51N can also specifically inhibit SIRT7 and replenish the substrate. Under ionizing radiation stimulation, the compound can effectively inhibit a SIRT7-ATM cell signal pathway.

The application discloses a detection kit based on a colorimetric method and application thereof, and the detection kit comprises two membrane protein recognition chains T1 and T2, two DNA hairpins H1 and H2 required for forming G-quadruplex, hematin required for a color developing reaction, hydrogen peroxide (H2O2) and ABTS. The membrane protein recognition chains T1 and T2 can anchor membrane proteins, and adjacent hybridization occurs when the membrane proteins dimerize, thereby triggering catalytic hairpin self-assembly of H1 and H2 to form a large number of G-quadruplex structures; when H2O2 exists, G-quadruplex / hematin formed by combining G-quadruplex and hematin can catalyze oxidation of ABTS to generate a color developing reaction. The detection kit has the characteristics of high sensitivity, good specificity, low cost, low dependence on equipment and simple operation in the detection of cell membrane protein dimerization, and also has good application performance in cell signal pathway visualization and rapid diagnosis of tumor cells at a bedside.

The invention discloses a beam collaboration method, device, equipment, medium and product between macro and micro cells. The method executed by an interfered micro base station comprises the following steps: receiving special beam measurement information reported by a plurality of user terminals in a serving cell; determining at least one interference sample according to the signal strength difference threshold value, the serving cell signal strength and the adjacent cell beam signal strength in each piece of beam dedicated measurement information; when it is detected that the number of the interference samples meets a sample proportion threshold value, according to the serving cell signal strength and the adjacent cell beam signal strength corresponding to each interference sample, determining a target beam power decline value of an interference applying adjacent cell; and according to the target beam power drop value and the corresponding target beam information, generating target beam adjustment information, and sending the target beam adjustment information to an interference-applying macro base station corresponding to the interference-applying neighbor cell so as to indicate the interference-applying macro base station to perform beam adjustment. According to the invention, fine beam cooperation between macro and micro cells can be realized, and signal interference of a macro base station to a micro base station is effectively reduced.

A wireless terminal is described. The wireless terminal includes receiving circuitry configured to receive a neighbor cell signal and to determine a non-terrestrial network (NTN) neighbor cell for a cell reselection process based on a calculation using a neighbor cell received signal power.

Provided are molecular feedback circuits employing caged-degrons. Aspects of such circuits include the use of a caged-degron to modulate the output of a signaling pathway in a feedback-controlled manner. Also provided are nucleic acids encoding molecular circuits and cells containing such nucleic acids. Methods of using caged-degron-based molecular feedback circuits are also provided, including e.g., methods of modulating a signaling pathway of a cell that include genetically modifying the cell with a caged-degron-based molecular feedback circuit.

The invention provides an abnormal neighbor cell identification method, a neighbor cell measurement optimization method and a mobile terminal. The method comprises the following steps: acquiring the cell signal quality of a neighbor cell; determining a first deduction score according to a difference value between the cell signal quality of the adjacent cell and the cell signal quality of the service cell; evaluating the cell signal fluctuation amplitude of the adjacent cell according to the cell signal quality of the adjacent cell, and determining a second deduction score according to the cell signal fluctuation amplitude; according to the first deduction score and the second deduction score, determining a health score of the adjacent cell; and judging whether the neighbor cell is abnormal according to the health score of the neighbor cell. According to the invention, the identification accuracy of the abnormal neighbor cell can be improved, the terminal is prevented from being switched to the abnormal neighbor cell, the switching reliability of the terminal is improved, and the measurement power consumption and air interface overhead of the terminal are reduced.

The invention provides a terminal equipment energy saving method and related equipment, and relates to the technical field of wireless communication. The method comprises: a terminal device receiving measurement relaxation configuration information for a serving cell and / or a neighbor cell sent by a network side device; the measurement relaxation configuration information for the serving cell and / or the neighbor cell comprises at least one of static mobility evaluation configuration, cell edge evaluation configuration, a main receiving module dormancy entry condition and a joint condition of any combination of the above conditions; the measurement relaxation configuration information for the serving cell and / or the neighbor cell is carried by at least one of a broadcast message, a first radio resource control (RRC) signaling, a low-power-consumption wake-up signal and a low-power-consumption synchronization signal; therefore, the terminal equipment is supported to keep an energy-saving or dormant state or execute measurement relaxation with a more loose requirement under the condition of low mobility or good signal quality of a serving cell, and the energy consumption of the terminal is effectively reduced.

The invention relates to the technical field of gene engineering technology, in particular to a preparation method of an efficient and stable gene knockout cell line. According to the AKAP11 gene knockout cell line provided by the invention, the 6th exon of the AKAP11 gene in the cell line is subjected to 3395bp frameshift deletion mutation, so that a coding frame is shifted, and protein translation is terminated in advance; after continuous subculture, the homozygous knockout phenotype is still maintained through PCR sequencing verification. A CRISPR / Cas9 system is combined with puromycin screening, the positive cloning rate reaches 30% or above, the construction period is shortened to 45 days, the constructed cell line can be directly used for AKAP11 related cell signal path research, disease model construction and targeted drug screening, and a reliable tool is provided for basic research and clinical transformation.