163 results about "Cells signal" patented technology

The invention discloses a preparation method of an oral liver protection composition containing ergothioneine, and relates to the technical field of ergothioneine application. The oral liver protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.5 to 5 parts of the ergothioneine, 10 to 30 parts of silibinin, 20 to 50 parts of a phospholipid complex, 5 to 15 parts of a liver targeting carrier, 2 to 8 parts of a disintegrating agent, 1 to 5 parts of an adhesive and 2 to 4 parts of an antioxidant. Free radicals are efficiently captured through a polycyclic conjugated pi electron system of the antioxidant, a hydrogen bond network is formed by a heteroatom bridging effect of the antioxidant, a galactose group of the liver targeting carrier and the disintegrating agent, and the stability of the system is synergistically improved; the phospholipid complex is embedded with a hydrophobic drug and a hydrophilic carrier, and the drug is accurately delivered to the liver by combining the specific recognition capability of the liver targeting carrier; the ergothioneine and the silybin form a bidirectional synergistic liver protection mechanism by removing reactive oxygen free radicals and regulating and controlling cell signal channels respectively.

The invention discloses a prediction method for identifying a protein-protein interaction site. According to the method, a deep learning framework is constructed based on protein chain hierarchical graph construction and double-branch graph neural network learning. The method comprises the following steps: firstly, constructing a corresponding hierarchical graph for each protein chain, including a residue-level graph and an atomic-level graph; next, the method constructs an isotropic graph neural network (EGNN) module to extract residue-level embedding with isotropic features. After a GraphSAGE module is further used for extracting atomic-scale embedding, the method integrates layered graph features by using a comparative learning strategy so as to learn residue-scale and atomic-scale consistency embedding. Finally, an improved gated multi-head attention mechanism is used for fusion embedding weighting, and residue-level interaction classification prediction is performed through a multi-layer perceptron. A comprehensive evaluation result on a plurality of data sets shows that the method is remarkably superior to an existing method. In conclusion, according to the method, various advanced technologies such as graph structure denaturation, multi-scale modeling and comparative learning are fused, and an accurate and steady solution with expansion potential is provided for protein interaction prediction. The method can assist researchers in deeply recognizing key protein acting sites and promoting analysis work of cell signal channels and metabolic networks.

The utility model provides a CCS thermal safety combination device for all-cell signal acquisition, which comprises a plastic uptake isolation plate used for being electrically connected with a battery assembly, the plastic uptake isolation plate is provided with a cell area and positioning areas, and the positioning areas are arranged on two opposite sides of the cell area; the FPC is mounted in the battery cell area and is electrically connected with the blister isolation plate; the fireproof sheet is arranged corresponding to the FPC and the blister isolation plate so as to cover the surface of the FPC and the surface of the blister isolation plate; and the insulating sheet covers the fireproof sheet and is fixedly connected with the blister isolation plate. The fireproof sheet is placed on the FPC to avoid the battery cell explosion-proof valve, and the whole insulating sheet is placed at the top end of the fireproof sheet, so that the battery cell can be effectively protected, heat spreading during thermal runaway of the battery cell is prevented, the risk of thermal runaway of the battery cell is reduced, and the maintenance and replacement cost of the battery is reduced.

The invention provides a communication method, device and system, a computer program product and a readable storage medium, and the method can be applied to a communication scene exemplarily. In the method, a terminal device receives a first measurement event and a second measurement event configured by a source access network device, and takes the first measurement event and the second measurement event related to estimated service time as execution conditions. The terminal device can select the target cell according to the estimated service time of the candidate cell and the estimated service time of the source cell to perform cell switching. Compared with the existing scheme that the target cell is selected only according to the cell signal quality, the terminal equipment can execute cell switching under the condition that the first measurement event and the second measurement event are triggered, and the terminal equipment can perform cell switching under the condition that the estimated service time of the source cell is short and the estimated service time of the candidate cell is relatively long. And switching to the target cell capable of providing relatively long service time, thereby reducing the frequency of switching the access network equipment by the terminal equipment, and improving the communication stability.

The invention discloses a culture method for improving proliferation and differentiation capacity of NK (Natural Killer) cells based on angelica sinensis-astragalus membranaceus exosomes, which comprises the following steps: firstly extracting exosomes in angelica sinensis and astragalus membranaceus, then adding the exosomes into an NK cell culture system according to a specific concentration, and regulating and controlling an NK cell signal channel by virtue of active ingredients carried by the exosomes so as to improve the proliferation and differentiation capacity of the NK cells. Therefore, the proliferation rate and differentiation maturity of the NK cells are remarkably improved. Experimental results show that compared with a traditional culture method, the proliferation multiple of the NK cells cultured through the method is increased by 28.99%-33.69%, the proportion of differentiated mature cells is increased by 15.91%-28.30%, and the cell killing activity is not remarkably reduced. The method can be widely applied to the field of immune cell treatment, provides a high-quality NK cell source for clinic, effectively solves the problems of slow cell proliferation rate, low differentiation maturity, easy activity reduction after large-scale culture and the like in traditional NK cell in-vitro culture, and has important clinical application value and industrialization prospect.

The invention discloses a prediction method, a terminal and network side equipment, and belongs to the technical field of communication, and the prediction method comprises the steps that the terminal obtains a first parameter; and the terminal determines whether to predict the signal quality of the cell based on the first parameter to obtain a predicted value.

Embodiments of this application provide a method for measuring signal quality of a cell, and a related apparatus. The method includes: receiving a measurement configuration from a network device, where the measurement configuration includes a trigger beam quantity, and the trigger beam quantity is a beam quantity threshold that triggers generation of a cell measurement result; determining that a quantity of detected beams is greater than or equal to the trigger beam quantity, where the detected beams belong to one or more cells; and obtaining a cell measurement result for the one or more cells based on signal quality of the detected beams. According to embodiments of this application, a frequency of reporting a measurement report can be decreased, reducing communication overheads.

A spectroscopic bioagent detection apparatus and method are provided. In one aspect, an optical detection system and method are used to identify and / or detect a virus or bacteria by using a microscope and measuring vibrational motion or phonons of the virus or bacteria. A further aspect of the present apparatus and method include automatically optically measuring vibrational motion or phonons of a target virus or bacteria, substantially in real-time, in vivo or in situ, automatically filtering out undesired background and living cell signals, and automatically identifying a characteristic of the virus or bacteria.

The invention discloses a scene recognition method and apparatus, a device and a storage medium. The method comprises the steps of obtaining first real-time information; wherein the first real-time information at least comprises one or more of the following items: sensor information; cell number change information; cell signal intensity change information; searching information by a satellite; a cell monitoring result; and performing scene recognition of the basement scene based on the first real-time information to obtain a scene recognition result.

A method for selectively targeting tumor cells for a given strain of cancer includes providing amino acids shown to discourage promotion of tumor growth for the given strain of cancer. The method may include determining the amino acids by identifying extracellular vesicles (EVs) involved in cell-cell signaling for tumor development, quantifying relative abundance of amino acids present in patient samples, comparing the relative abundance of the amino acids from the patient sample to a known distribution of the individual amino acids present in a nonmalignant sample, and comparing the abundance of the amino acids in the patient sample to the nonmalignant sample to determine the plurality of amino acids suitable for treating the given strain of cancer. The method may include supplementing the combination of the plurality of amino acids with a chemotherapy drug.

A touch controller is used to control a touch panel. The touch panel has an array of sensor cells divided in to N columns, each column has M regions, M regions are grouped into P zones. The touch controller has a switch circuit and a sensing circuit. In a coarse scan period, the switch circuit shorts the sensor cells in each zone of each column, and the sensing circuits scans P×N zones of the N columns to generate P×N zone signals. In M fine scan periods, the switch circuit decouples the sensor cells in a triggered zone of the P×N zones, and the sensing circuit scans a region of the triggered zone without scanning untriggered zones of the P×N zones to generated cell signals.

The invention relates to a communication method, a terminal, network equipment, a communication system and a storage medium. The communication method comprises the following steps that: a response terminal is in a non-connection state, the terminal measures the signal quality of a cell in a DRX (discontinuous reception) opening time period in N DRX periods, N is smaller than or equal to M, and M is the number of the DRX periods used for evaluating the quality of received signals of the cell. Through the embodiment of the invention, the power consumption of the terminal can be reduced.

The present disclosure relates to a primary secondary cell processing method, a terminal and a computer storage medium, and relates to the technical field of communication. The primary secondary cell processing method is executed by a terminal, and includes: obtaining, from a primary base station, configuration information of at least one candidate primary secondary cell corresponding to a non-ground access network-based secondary base station and a required trigger condition for switching, the candidate primary secondary cell has an overlapping area with a primary cell of the primary base station, and the trigger condition includes at least one of a time condition and a location condition, and a cell signal quality condition; judging whether each candidate primary secondary cell meets the corresponding trigger condition; in the case that at least one candidate primary secondary cell meets the corresponding trigger condition, selecting a target primary secondary cell from the at least one candidate primary secondary cell; and accessing the target primary secondary cell according to the configuration information of the target primary secondary cell.

The application discloses a flow cytometer sorting control system, a sorting method and a storage medium, and belongs to the technical field of flow cytometer sorting. The flow cytometer sorting control system provided by the application comprises an interface for interacting with user software, an analog-to-digital conversion module, a data processing module, a sorting identification module, a sorting delay module and a sorting actuator. The application further provides a method for sorting cells by using the flow cytometer sorting control system provided by the application, wherein the method comprises a new sorting identification method and a new delay method. By using the control system and the sorting identification method provided by the application, the calculation time can be greatly shortened and the sorting speed can be improved when complex circle gates are used under the same calculation speed of hardware; meanwhile, the time difference between the start of liquid drop charging and the disconnection of the liquid drop can be fixed, the sorting stability and reliability can be ensured, the judgment of cell spacing for each cell is not needed, the judgment of whether each cell is a target cell is not needed, the processing process of cell signals is simplified, and the requirement for electronic performance is reduced.

This disclosure provides a method for determining the beam failure detection (BFD) relaxation state, wherein the method is executed by a terminal, and the method includes: in a multiple transmit / receive node (mTRP) scenario, determining whether the terminal is in a relaxation state based on predetermined rules; wherein the relaxation state is a state in which the terminal can perform BFD relaxation; the predetermined rules include at least one of the following: a low mobility criterion; and a good cell signal quality criterion. Here, in the mTRP scenario, the terminal's presence or absence in the relaxation state can be determined based on the low mobility criterion and / or the good cell signal quality criterion. Compared to situations where it cannot be clearly determined whether the terminal is in or not in a relaxation state, BFD relaxation can be performed based on the determination result, improving the reliability of wireless network communication.

The invention relates to an expression line resisting composition containing cell signal factors and plant active ingredients and a skin care product of the expression line resisting composition. The expression line resisting composition is prepared from the following components in percentage by mass: 10 to 50 percent of cell signal factors, 10 to 50 percent of flos chrysanthemi extract and 10 to 50 percent of camellia seed oil. By adopting a composite strategy of metabolism regulation and neuromuscular regulation, nerve-muscular signal conduction is regulated, facial muscle tension is weakened, and dynamic formation of expression lines is reduced; the AMPK energy metabolism pathway is activated, and the cell activity is improved; rOS accumulation in cells is reduced, and the mitochondrial function is improved; strong fat-soluble anti-oxidation protection is provided, the action time is prolonged, barrier repair, moistening and anti-inflammation are facilitated, and therefore the more efficient expression line resisting effect is achieved.

To provide agents for modulating cell signaling and / or cellular activities.SOLUTION: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and / or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.SELECTED DRAWING: Figure 3

The present application relates to compositions comprising fusion proteins and cells expressing the proteins. The application further relates to methods of using the fusion proteins, cells, and compositions for modulating cell signaling and for selective expansion of cells.

A touch controller is disclosed for controlling a touch panel. The touch panel includes an array of a plurality of sensing units, the plurality of sensing units are divided into N columns, each column includes M ranges, and the M ranges in each column are grouped into P regions. The touch controller includes a switching circuit and a sensing circuit. During a coarse scan, the switching circuit couples the plurality of sensing units in each region of each column to each other, and the sensing circuit scans the P x N regions of the N columns to generate P x N region signals. During M fine scans, the switching circuit uncouples the plurality of sensing units in a triggered region of the P x N regions from each other, and the sensing circuit scans the ranges in the triggered region without scanning the plurality of untriggered regions of the P x N regions to generate a plurality of cell signals of the plurality of sensing units in the triggered region.

The invention discloses a battery pack monitoring system and method based on a built-in sensor, the battery pack comprises a plurality of battery cells, the system comprises a plurality of battery cell internal monitoring assemblies, a module data acquisition unit and a monitoring terminal, the battery cell internal monitoring assemblies are packaged in the battery cells, and the module data acquisition unit is connected with the monitoring terminal. The module data acquisition unit is respectively in wired connection with the plurality of battery cell internal monitoring assemblies, and the monitoring terminal is in wireless or wired communication with the module data acquisition unit; the cell internal monitoring assembly comprises a miniature PCB, a pressure sensor, a temperature sensor and a signal terminal, and the pressure sensor and the temperature sensor are integrated on the miniature PCB; the signal terminal is arranged on a cover plate of the battery cell, and the signal terminal comprises a battery cell positive pole, a battery cell negative pole and a signal line pole. According to the system and the method, the problems of large external monitoring error, unreliable wireless transmission, sealing failure of wired transmission, multi-cell signal interference and the like in the prior art are solved.

The application relates to the field of cell signal detection, in particular to a multi-size microelectrode array detection device coupled with microelectroporation and a preparation method thereof. The multi-size microelectrode array detection device comprises a first microelectrode array device, a second microelectrode array device, and an electrophysiological signal acquisition module. The first microelectrode array device comprises a first chip, a first printed circuit board and a first cell culture chamber, and the first chip comprises a plurality of microelectrodes with mixed sizes. The second microelectrode array device comprises a second chip, a second printed circuit board and a second cell culture chamber, and the second chip comprises a plurality of microelectrodes with the same size. The microelectrodes on the second chip of different second microelectrode array devices are not the same in size. The electrophysiological signal acquisition module collects the electrophysiological signals of cells collected by the first microelectrode array device and the second microelectrode array device. An upper computer stores and displays the electrophysiological signal data collected by the electrophysiological signal acquisition module. The application improves the adaptability of the cell detection device and the accuracy of the cell electrophysiological signal detection result.

1. The name of the design product: multifunctional enzyme label instrument. 2. The use of the design product: for nucleic acid, protein concentration, enzyme activity analysis and other conventional molecular detection; signal transduction research, cell signal event active oxygen, modification detection; cell viability, apoptosis, killing and other overall level analysis. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention describes a method to infer the Hippo cellular signaling pathway activity in a sample based on assessing the expression levels of six or more predefined target genes. The invention further describes the use of the method in prognostic and diagnostic applications and use of the method to determine or predict therapy resistance.

Antibodies that specifically bind to TrkB and methods for using the same are described. Neuroprotective agonist antibodies are described, as indicated by their effect on enhancing the survival of retinal ganglion cells in vitro, and these agonist antibodies may be used to treat eye disorders, such as glaucoma. Additionally, other neuronal diseases or disorders, including those characterized by partial neuronal damage, benefit from treatment using these agonist antibodies. In certain embodiments, the present invention comprises antibodies that bind to TrkB and mediate cell signaling. The antibodies of the present invention may be whole human, non-natural antibodies formulated as injectable excipients.

The invention provides a communication method and a communication device. The method comprises: receiving first indication information, the first indication information indicating information of N data rates, the data rates having an association relationship with cell signal quality; measuring the M cells to obtain the cell signal quality of the M cells; and determining a data rate associated with the cell signal quality of the M cells based on the first indication information, and further determining a service processing strategy and / or a cell management strategy based on the data rate associated with the cell signal quality of the M cells, the cell management strategy being any one of the following: a cell selection strategy, a cell reselection strategy, and a cell switching strategy. Based on this, when the processing strategy of the service and the cell management strategy are determined, the rate (namely the data rate associated with the cell signal quality) which can be provided by the cell is considered, so that the terminal can efficiently decide the processing strategy of the service and the cell management mode, and the user experience can be improved and the resource waste can be reduced.

Antibodies that specifically bind to TrkB and methods of use thereof are disclosed. Agonist antibodies having neuroprotective effects, as shown by their ability to enhance retinal ganglion cell survival in vitro, are disclosed, and these agonist antibodies can be used in the treatment of conditions such as eye diseases, including glaucoma. In addition, other neuronal diseases or conditions can also benefit from treatment with these agonist antibodies, including those characterized in part by neuronal damage. In certain embodiments, the present invention includes antibodies that bind to TrkB and mediate cell signaling. The antibodies of the present invention can be fully human, non-naturally occurring antibodies formulated with an excipient for injection.

A bridge is provided, including a donor bridge node and one or more serving bridge nodes. The donor bridge node is configured to connect to a base station aggregation location including cell signals; determine a serving link carrier frequency in a serving link frequency band and a bridge link carrier frequency in a bridge link frequency band for each cell signal; associate the cell signals and the determined carrier frequencies in the serving link frequency band and the bridge link frequency band with the one or more serving bridge nodes; and communicate each cell signal with the one or more serving bridge nodes associated with each cell signal through the bridge link carrier frequency of the cell signal in the bridge link frequency band. The one or more serving bridge nodes are configured to communicate with the donor bridge node through the carrier frequencies of the bridge link frequency band and communicate with user equipment in the serving link carrier band of the serving link frequency band associated with one cell signal.

The present invention includes methods and computer programs for use in the detection preeclampsia and / or determining an increased risk for preeclampsia in a pregnant female, the methods including identifying in a biosample obtained from the pregnant female cell-free DNA signals, including concentration, fetal fraction, and fragment size distribution. These methods provide for the identification of patients at risk of preeclampsia in the first trimester of pregnancy.

Disclosed herein are cell signaling complexes, such as chimeric cytokine complexes, and their uses. In some embodiments, the chimeric cytokine complex comprises a protein cage polypeptide, a plurality of engineered Fc antibody domains bound to the protein cage polypeptide, and one or more cytokines linked to each of the plurality of engineered Fc antibody domains. Also disclosed are Fc-cytokine complexes and their uses. In some embodiments, the Fc-cytokine complex comprises engineered Fc antibody domains and one or more cytokines linked to the engineered Fc antibody domains.

The present disclosure relates to compositions and methods for modulating signaling in a cell and / or for differentiating / maturing a cell. Compositions of this disclosure, as may be used in associated methods, may include first and second segments that are connected to one another. When used in methods to differentiate and / or mature immune cells, compositions of this disclosure advantageously increase frequency and yields of arising cells in comparison to conditions deploying only first or second segments separately, or both individually (not connected).