Sterilization method of classic famous formula Kaixin powder

Abstract

The invention discloses a sterilization method of classic famous formula Kaixin powder, which comprises the following steps: (1) heating Kaixin powder to 60-75 DEG C, and standing for 10-30 minutes; naturally cooling to 20-25 DEG C, adding ethanol with the volume fraction of 75-85% into the Kaixin powder, mixing, and standing for 12-24 hours to obtain primary sterilized powder; and (2) heating the powder sterilized for the first time to 60-75 DEG C, vacuumizing to-0.08 to-0.01 MPa, introducing ethanol steam, and keeping for 0.5-2 hours, thereby obtaining the product. The invention focuses on the influence of the sterilization method on the effective components in the Kaixin powder and the drug effect, and provides the sterilization method of the classic famous formula Kaixin powder from the characteristics of the four medicinal materials of the Kaixin powder, so that the effective sterilization is realized, the loss of the effective components of the Kaixin powder is avoided, and the treatment effect and medication safety of the medicine are ensured.

Description

technical field [0001] The invention belongs to the field of sterilization of traditional Chinese medicines, and in particular relates to a sterilization method of a classic famous prescription Kaixin San. Background technique [0002] The classic famous prescription Kaixin San is one of the first batch of 100 prescriptions selected into the "Ancient Classical Prescription Catalog (First Batch)" formulated by the State Administration of Traditional Chinese Medicine in conjunction with the State Drug Administration in 2018. It was first recorded in the medical science of the Tang Dynasty. "Emergency Prescriptions for Thousands of Gold" written by author Sun Simiao. The prescription is composed of ginseng, polygala, calamus, and poria cocos, and its composition is analyzed according to the "Basic Theory of Traditional Chinese Medicine". Calamus reduces phlegm and resuscitates, refreshes the mind; Polygala calms the mind and calms the nerves, eliminates phlegm and resuscitates...

AI Technical Summary

Problems solved by technology

[0004] At present, methods for sterilizing traditional Chinese medicine powder include moist heat sterilization, dry heat sterilization, high-pressure steam sterilization, ethanol steam sterilization, radiation sterilization, etc., but they all have their own limitations such as: (1) dry heat and The high temperature of moist heat sterilization will affect the heat-sensitive active ingredients or volatile ingredients; (2) Radiation sterilization may have radiation residues; (3) Chen Ying et al. reported that Kaixin Powder was sterilized at 111°C by high-pressure steam sterilization At 60s, the overall loss rate was the smallest, but the calamus contained in the prescription of Kaixin Powder contained volatile oil components, which would cause the loss of its volatile components α-asarone and β-asarone during the high temperature process, resulting in a decrease in the efficacy index components; In the high temperature sterilization process, polygala Ketone III, 3,6′-Dierucanoyl sucrose, Siberian polygala A5 and Siberian polygala A6 may also change with temperature, while ginsenoside Rg 1 Glycosyl hydrolysis and dehydration reactions are prone to occur with ginsenoside Re under high temperature conditions, and the above changes will affect the clinical efficacy of Kaixin San; (4) Conventional ethanol sterilization can only kill propagules, and for spores of microorganisms in the dormant stage It is said that due to the thick spore membrane, ethanol is not easy to penetrate, resulting in the unsatisfactory killing effect of ethanol on spores.

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