Application of rhynchophylline in preparation of medicine for treating inflammatory enteritis
A technology for inflammatory bowel disease and rhynchophylline, which is applied in the field of application of rhynchophylline in the preparation of drugs for treating inflammatory bowel disease, can solve problems such as restriction, drug allergy-dependent drug resistance, liver and kidney function damage, etc., and achieve the reduction of intestinal mucosa Permeability, effect of promoting intestinal barrier integrity
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[0032] (1) Animal grouping and administration
[0033] 60 C57 / BL6j mice aged 6-7 weeks and weighing 18-22g were divided into control group, positive drug group, model group, and urticine (low, medium and high) dose groups, with 10 mice in each group. The mice in the control group were given normal diet and drinking water every day without treatment. Mice in the model group, urticine (low, medium, high) group and positive drug group freely drank 2% DSS (dextran sodium sulfate) solution instead of drinking water and ate freely every day. The mice in the control group and the model group were given 0.1ml / 10g body weight of sterile water by gavage every day, and the rhynchophylline (low, medium, and high) groups were respectively given an aqueous solution of rhynchophylline (2mg / kg in the low-dose group and 4mg in the middle-dose group). / kg, high-dose group 8 mg / kg) once a day for 7 consecutive days. The positive drug group was injected intraperitoneally with dexamethasone 0.00...
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