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Application of montmorillonite in preparation of medicine for reducing absorption of radioactive elements by human body

A technology of radioactive elements and montmorillonite, which is applied in drug combinations, anti-toxic agents, active ingredients of aluminum/calcium/magnesium, etc., can solve the problems of inability to reduce the absorption of radionuclides and the limited effect of substances, and achieve the protection of the human body Healthy, Avoid Absorbed Effects

Pending Publication Date: 2022-07-08
ACADEMY OF MILITARY MEDICAL SCI
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  • Claims
  • Application Information

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Problems solved by technology

However, most of the existing methods for reducing the intake of radionuclides by the human body use some chemically synthesized drugs, but these substances have limited effects and cannot effectively reduce the absorption of radionuclides by the human body. Therefore, further research on reducing the absorption of radionuclides by the human body has very important

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  • Application of montmorillonite in preparation of medicine for reducing absorption of radioactive elements by human body
  • Application of montmorillonite in preparation of medicine for reducing absorption of radioactive elements by human body
  • Application of montmorillonite in preparation of medicine for reducing absorption of radioactive elements by human body

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Embodiment

[0022] The montmorillonite was added with purified water to prepare a solvent of 400 mg / kg, 600 mg / kg and 800 mg / kg, respectively.

[0023] 1. Pharmacological experiments on absorption of cesium

[0024] (1) Experiments with different dosages

[0025] 72 SD rats were divided into 6 groups according to body weight, 12 rats in each group, half male and half male, the first group was the blank control group, the second group was the model control group, and the third group was the low-dose montmorillonite group. (400mg / kg), the fourth group was the montmorillonite middle dose group (600mg / kg), the fifth group was the montmorillonite high dose group (800mg / kg), and the sixth group was the positive drug Prussian blue group.

[0026] The rats in the blank group were given purified water according to their body weight after fasting for 24 hours. After fasting for 24 hours, the rats in the second to sixth groups were given 12 mg / mL cesium ion solution by intragastric administration ...

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Abstract

The invention provides application of montmorillonite in preparation of a medicine for reducing absorption of radioactive elements by a human body, and relates to the field of medicines. The invention provides application of montmorillonite in preparation of a medicine for reducing absorption of radioactive elements by a human body. Radioactive elements are released into the environment after a nuclear accident, internal irradiation injury can be caused to a human body, acute radiation sickness and high incidence of cancers of the human body are caused, the montmorillonite structure carries negative charges, so that the montmorillonite can adsorb numerous metal cations, and the montmorillonite cannot be absorbed by gastrointestinal tracts, so that the adsorbed ions can be taken out of the body together, and therefore, the treatment effect of the montmorillonite is improved. Meanwhile, the radioactive elements can be taken out of the body, so that the human body is prevented from absorbing the radioactive elements, and the health of the human body is protected.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the use of montmorillonite in the preparation of a medicine for reducing the absorption of radioactive elements by the human body. Background technique [0002] Montmorillonite is a layered mineral composed of extremely fine-grained hydrous aluminosilicate, also known as kaolinite or microcrystalline kaolinite, which is altered by igneous rocks such as volcanic condensate in an alkaline environment. The main component of bentonite. The name of montmorillonite comes from the place where it was first discovered - Montmorillon in France. The montmorillonite subgroup belongs to one of the smectite minerals (the other subgroup is saponite), and is an important clay mineral, generally in the form of lumps or soils. Molecular formula (Na,Ca)0.33(Al,Mg)2[Si 4 O 10 ](OH) 2 ·nH 2 O, a clay mineral with a three-layer sheet structure composed of an aluminum-oxygen octahedron in the midd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61P39/02
CPCA61K33/06A61P39/02
Inventor 李彬董俊兴张广杰田瑛郑亚萍李敏刘思凡
Owner ACADEMY OF MILITARY MEDICAL SCI
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