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Eye drops of fluconazole

A technology of fluconazole and eye drops, applied in the direction of organic active ingredients, sensory diseases, medical preparations containing active ingredients, etc., to achieve the effect of long residence time, less usage, and less tear dilution

Inactive Publication Date: 2005-03-30
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fluconazole used as eye drops has not yet seen any research and production reports

Method used

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  • Eye drops of fluconazole
  • Eye drops of fluconazole

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Experimental program
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Embodiment Construction

[0008] Prescription 1:

[0009] Fluconazole 5.0g

[0010] Propylene glycol 22.0g

[0011] Benzalkonium Chloride 0.1g

[0012] Add water for injection to full amount

[0013] Makes 1000ml

[0014] Operation process:

[0015] ①Take the prescribed amount of fluconazole, stir and mix with propylene glycol to fully disperse it evenly;

[0016] ② Add appropriate amount of water for injection and dissolve;

[0017] ③Take another benzalkonium chloride, add water to dissolve it, add it to ②, and stir evenly;

[0018] ④Replenish water to the full amount, filter, sterilize by heating, and pack it separately to get ready.

[0019] Prescription 2:

[0020] Fluconazole 1.0-25.0g

[0021] Propylene glycol 0-110.0g

[0022] Benzalkonium Chloride 0-0.5g

[0023] Add water for injection to full amount

[0024] Makes 1000ml

[0025] Operation process:

[0026] ①Take the prescribed amount of fluconazole, stir and mix with propylene glycol to fully disperse it evenly;

[0027] ② Add...

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Abstract

A diflucan eye drops for treating fungal injection of eye is prepared from diflucan and propanediol through mixing, grinding, adding the water for injection, dissolving benzalkonium chloride in water for injection, mixing and stirring.

Description

Technical field [0001] The invention relates to an active ingredient of medicine - fluconazole - which is made into eye drops for the first time and applied to the treatment of ophthalmic fungal infection. Background technique [0002] In the past ten or twenty years, fungal infectious eye diseases have gradually increased, especially the widespread use of antibiotics, corticosteroids and immune agents in clinical practice, which has further increased the upward trend of fungal eye diseases. At present, there is no antifungal ophthalmic drug for topical application in China, and injection or oral preparations are generally used for clinical treatment. Fluconazole used as eye drops has not yet seen any research and production reports. Contents of the invention [0003] The antifungal infection drug fluconazole was made into eye drops for the first time, which not only overcomes the disadvantages of large dosage and difficulty in passing oral drugs through the blood-ocular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61P27/02
Inventor 刘继东姚东民高峨宋长海
Owner SHENYANG XINGQI PHARM CO LTD
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