Process for producing gelfoam particle embolism agent

A technology of gelatin sponge and manufacturing process, which is applied in the direction of suppository delivery, etc., and can solve the problems of high particle size and high price

Active Publication Date: 2005-09-14
杭州艾力康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The key technology of interventional therapy is the particle embolism used to block the blood supply of tumor tissue, which has a high requirement on the size of the particle, and now the foam particles imported from abroad are more expensive; how to prepare a cheap and good particle embolism The manufacturing process is the problem to be solved in the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Embodiment 1: The manufacturing process of this gelatin sponge particle embolic agent is mainly realized by the following steps, 1), the gelatin sponge is crushed and dried; specifically, the gelatin sponge formal is first frozen at a temperature of -10°C , frozen for more than 24 hours until it is as hard as a stone, then crushed in a pulverizer to the required particle size, and then dried in a drying oven; after sieving and grading, put it into a cleaned and disinfected vial It can be divided into different grades according to the particle size, 50-100 microns, 150-350 microns, 350-1400 microns, 1400-2000 microns.

Embodiment 2

[0008] Embodiment 2: The manufacturing process of this gelatin sponge particle embolic agent is mainly realized by the following steps, the gelatin sponge is crushed and dried; specifically, the gelatin sponge formal is first frozen at a temperature of -30 ° C, and the freezing time More than 2 days, and then crushed in a pulverizer to the required particle size, and then dried in a dry box; after sieving and grading, put it into cleaned and disinfected vials for packaging and capping.

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PUM

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Abstract

The invention relates to a manufacturing process of a gelatin sponge particle embolic agent, which is mainly realized by the following steps: crushing and drying the gelatin sponge; specifically, firstly freezing the gelatin sponge at a temperature of -10°C-30°C, and freezing the gelatin sponge The time is at least half an hour, and then crushed in a pulverizer, and then dried in a dry box; after sieving and grading, put them into cleaned and disinfected vials for packaging and capping. The beneficial effect of the present invention is that the gelatin sponge can be crushed into required particle sizes due to the adoption of the freezing and crushing process, and a series of products can be formed, which are suitable for the needs of interventional therapy. Gelatin sponge not only has hemostatic effect on wound bleeding, but also has embolism effect.

Description

technical field [0001] The invention relates to a production process of an embolic agent, in particular to a production process of a gelatin sponge particle embolic agent. Background technique [0002] At present, in medical technology, as interventional therapy becomes more and more mature, the frequency of use is also increasing. Interventional medicine is the third major clinical discipline after internal medicine and surgery. Interventional therapy is not only different from "taking medicine and injection" in internal medicine, but also different from "surgery" in surgery. Instead, it is guided by high-definition medical imaging equipment. The catheter is inserted into the tumor site in the human body through a small incision, and then anti-tumor drugs are perfused through the blood supply artery or the blood supply of the tumor tissue is blocked, so that the tumor can be necrotic and shrunk in a short time to achieve the purpose of treatment. Due to the advantages of l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02
Inventor 郑隆泗
Owner 杭州艾力康医药科技有限公司
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