The invention belongs to the field of medical instruments, and discloses a cardiovascular intervention therapy device which comprises a needle tube. A one-way valve is embedded into the front end of the needle tube, a rubber positioning piece is vertically mounted on the one-way valve, a push rod is movably mounted inside the needle tube, a hole plug is arranged inside the push rod, a rubber plugis fixedly mounted at the front end of the push rod and clamped inside the needle tube, a through hole is formed in the front end of the rubber plug, an elastic sealing diaphragm is mounted inside thethrough hole, a guide wire hole is formed in the rear end of the push rod and communicated with the hole plug, a push plate is integrally mounted at the rear end of the push rod, and a conical blockis arranged in the middle of the push plate. The one-way valve is arranged at a needle head of the cardiovascular intervention therapy device, when the needle head is inserted into a blood vessel, a clamping valve flap further clamps a guide wire under reverse thrust of blood pressure, reverse flow of blood is decreased, annular valve flaps are arranged in a needle cylinder and a piston, reverse flow of the blood is reduced to the minimum, surgical safety is greatly improved, pollution to a worktable top is avoided, and bacterial pollution is reduced.