Biomedical magnesium or magnesium alloy implantation material with multiple surface protection

Abstract

The invention discloses a magnesium or magnesium alloy material or device with multiple surface protection layers and a production method. The magnesium or magnesium alloy material or device with multiple surface protection treatment has the aims that the initial mechanical attenuation of magnesium / magnesium alloy in a physiological environment is decelerated, the corrosion resisting property of the magnesium / magnesium alloy is improved, and the time of service is effectively prolonged. The protection treatment comprises the steps: 1) manufacturing a magnesium / magnesium alloy substrate, and cleaning the surface of the substrate; 2) carrying out chemical conversion treatment on the surface of the magnesium / magnesium alloy substrate, so as to grow a chemical conversion film, of which the thickness is several nanometers, on the surface of the substrate; 3) coating the chemical conversion film with an adhesive layer; 4) coating the outside surface of the adhesive layer with a degradable polymer film. The magnesium or magnesium alloy material or device with multiple surface protection treatment, provided by the invention, can be applied to biomedical implantation or intervention therapy and has the advantages of being good in initial corrosion resisting property in a human physiological environment, meeting clinical requirements of medical treatment and being finally in-vivo degradable.

Description

technical field [0001] The invention belongs to the field of biomedical materials and devices for implantation or interventional therapy, in particular to a biomedical magnesium or magnesium alloy implant material with multiple protective layers on the surface. Background technique [0002] With the aging trend of my country's population increasing year by year, orthopedic diseases such as cardiovascular disease, osteoporosis and arthritis, as well as diseases such as general surgery and stomatology, the market demand for materials and devices for implantation and interventional therapy is also increasing. rising day by day. Among such medical materials and devices, metal materials have been widely used in clinical treatment because of their good mechanical strength and toughness, resistance to fracture fatigue, suitable for load bearing, and easy processing and forming. At present, stainless steel, titanium or cobalt-chromium alloys are routinely used for implantation or in...

AI Technical Summary

Problems solved by technology

However, some treatment methods have potential hazards to human health, such as chromate treatment, surface nickel plating, aluminum, iron, etc.; some treatment methods cannot meet the requirements of degradability, such as ceramic layers prepared by anodic oxidation or micro-arc oxidation , titanium layer and most organic coatings are difficult to degrade in the human environment

In addition, many methods that can provide protection in theory may not be able to achieve the actual protection effect in practice.

For example, the combination of degradable magnesium / magnesium alloys and degradable polymer materials can theoretically delay the corrosion rate of magnesium / magnesium alloys and prolong the service life of implanted devices. The penetration of water molecules cannot be prevented, and the magnesium / magnesium alloy will start the degradation reaction at the same time as the polymer material. The hydrogen gas generated during the magnesium degradation process will directly cause the bubbling of the polymer film on its surface, or even fall off.

[0009] To sum up, although in the development of biomedical equipment, in vivo biodegradable magnesium and its alloy materials have received high attention, long research and development time, and large investment in research and development, so far, there has not been an ideal one that has long-lasting effective performance. Magnesium and its alloy materials with controllable degradation rate, complete degradability, good biocompatibility and simple preparation process

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