Novel titanium stent for aged coronary artery and treatment method of titanium stent

A coronary, a new type of technology, applied in the field of medical appliances

Inactive Publication Date: 2017-05-31
淮安市第二人民医院(淮安仁慈医院)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the use of titanium alloy materials as coronary stent materi

Method used

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Embodiment Construction

[0022] The present invention will be further described with reference to examples.

[0023] Chinese medicine GDP preparation

[0024] Wash fresh snails in ice water. Remove the shell and impurities, pulverize with a high-speed pulverizer, make a homogeneous slurry and keep it in 90% ethanol for two weeks. Use 1:20 distilled water to extract once every 4 hours at a temperature of 85-87°C, a total of three times. The mixture was centrifuged for 20 minutes to remove insoluble residues. The supernatant was collected, concentrated to an appropriate amount by a vacuum rotary evaporator, protein was removed by Sevag, Lackman, Smolens and absolute ethanol, and left overnight at 4°C. The precipitate was centrifuged for 20 minutes to extract GDP.

[0025] Purification of traditional Chinese medicine GDP

[0026] GDP was purified sequentially by chromatography DEAE-52 and Sephadex G-100. GDP (3ml, 15mg / ml) was purified by chromatographic column (2.6cm × 30cm) DEAE-52 cellulose, and...

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PUM

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Abstract

The invention discloses a novel titanium stent for aged coronary artery and a treatment method of the titanium stent. A stent body is made of a titanium material. The treatment method comprises the following steps of adsorbing a nanoparticle composition onto the surface of the stent body; after the surface of the stent body is polished and cleaned, soaking the stent body into an NaOH (sodium hydroxide) solution, reacting for 10h at the temperature of 70 DEG C, cleaning by ultrasonic waves in primary distilling water, soaking into secondary distilling water, reacting for 10h at the temperature of 70 DEG C, cleaning by ultrasonic waves in primary distilling water, and drying at the temperature of 37 DEG C; soaking the stent body into PLL (poly-l-lysine), standing for reacting for 20h at the temperature of 4 DEG C, and cleaning the stent body by a phosphate buffer solution. The GDP (guanosine diphosphate) at the surface of the stent body is combined with HEP (haperin), PLL, LN (laminin) or SDF-1apha (stromal derived factor-1alpha) to build a biological functional micro-environment with effects of coronary artery immune regulation, blood compatibility, coronary artery thrombus formation inhibition, coronary artery endothelial injury recovery, and coronary interventional treatment restenosis inhibition, so as to possibly solve the problems of coronary artery thrombus formation and restenosis caused by intervention therapy for coronary multi-vessel lesions and complex coronary artery lesion.

Description

technical field [0001] The invention relates to a medical appliance, more specifically, it relates to a novel titanium stent suitable for elderly coronary arteries and a processing method for the titanium stent. Background technique [0002] The incidence of coronary thrombosis and coronary restenosis caused by interventional treatment of multi-vessel coronary artery (coronary) disease and complex disease in the elderly over 70 years old is significantly higher than that in young patients with coronary heart disease. Titanium alloy materials have good biocompatibility and have been widely used in peripheral vascular stents. However, there is no research on the use of titanium alloy materials as coronary stent materials for interventional treatment of elderly coronary multi-vessel lesions and complex lesions. Contents of the invention [0003] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a novel titanium stent suitable fo...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/20A61L27/18A61L27/22A61L27/30A61L27/34
CPCA61L27/06A61L27/18A61L27/20A61L27/22A61L27/30A61L27/34A61L2300/232A61L2300/252A61L2430/22C08L77/04C08L5/10C08L89/00
Inventor 李侠熊清平刘涛蒋长兴胡有东张枫林赵庆娜
Owner 淮安市第二人民医院(淮安仁慈医院)
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