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Methyleneseleno propanel method for preparing selenoic methionine

A technology of selenomethionine and methylselenopropanal, which is applied in the field of amino acid drugs and can solve the problems of low yield, restrictions on the development of selenoanalogs of methionine, and large-scale equipment.

Inactive Publication Date: 2005-09-21
董国臣
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Problems solved by technology

[0008] The existing preparation method of selenomethionine, whether it is chemical synthesis method or biosynthesis method, has complex process conditions and difficult management; low product concentration and low yield; large-scale equipment and small profit
Therefore, selenomethionine products cannot meet the supply and demand of the market, and limit the development of selenomethionine analogues

Method used

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  • Methyleneseleno propanel method for preparing selenoic methionine
  • Methyleneseleno propanel method for preparing selenoic methionine
  • Methyleneseleno propanel method for preparing selenoic methionine

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Embodiment Construction

[0021] The chemical synthesis methods for producing methionine mainly include Strecker method, malonate, aminolactone method and Heine method, most of which are used at home and abroad. Among them, the important intermediate methylselenopropanal, which is an important intermediate of the Heine method and the malonate method, uses methylselenol instead of methylmercaptan to react with acrolein to synthesize the methylselenopropionaldehyde intermediate, and realizes the chemical synthesis of selenium on the methionine production line. Methionine, that is, methylselenopropionaldehyde method to prepare selenomethionine.

[0022] Manufacturing method:

[0023] Routing:

[0024]

[0025]

[0026] crafting process:

[0027] 1. Dehydration: Yield 95% (in propylene) or 70% (in glycerin), batching ratio, glycerol: potassium bisulfate: potassium sulfate=1: 0.5: 0.26. Put 1 / 7 amount of glycerin and all potassium bisulfate and potassium sulfate into the reaction kettle, start addi...

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Abstract

A process for preparing selenoic methionine by methyleneseleno propanal method includes preparing the important intermediate, methyleneseleno propanel, from methyleneselenol, acroleic acid relative compounds by chemical synthesis, and chemically synthesizing selenoic methionic from it along with se and methionine by conventional process. The resultant product has excellent more bioactivities and the insulin-like action, so it can be used for treating diabetes.

Description

(1) Technical field: [0001] The invention belongs to the field of amino acid drugs, and relates to the preparation of selenomethionine by chemical synthesis intermediate methylselenopropanal; [0002] The present invention also relates to the technique for treating diabetes by the insulin-like effect of biological trace element and amino acid complex selenomethionine. (two) background technology: [0003] As we all know, since the important biological activity of the trace element selenium exists in the form of selenium-containing amino acids in organisms, especially selenomethionine is widely used in medicine, health care, agriculture, nutrition and other departments, and the preparation method of selenomethionine has been paid attention to. [0004] 1. Existing technology: [0005] (1) Liquid ammonia method (Na / ligNH 4 ) Preparation of selenomethionine: In order to obtain selenomethionine, (selenium)-benzylselenohomocysteine ​​is usually used to reductively remove the be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C391/00
Inventor 董国臣
Owner 董国臣
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