Method for synthesizing triphenyl phosphine dichloride

Abstract

A process for synthesizing phosphine triphenyldichloride features the reaction between phosphine triphenyloxide and triphosgene or biphosgene in organic solvent under existance of the nucleophilic catalyst chosen from N,N-dimethyl formamide, triethylamine, pyridine, etc.

Description

technical field [0001] What the present invention relates to is the synthetic method of triphenylphosphine chloride. Background technique [0002] Triphenylphosphine dichloride is the important intermediate of synthetic triphenylphosphine, especially in the by-product triphenylphosphine oxide of Wittig reaction as raw material, in the method for synthesizing triphenylphosphine, triphenylphosphine dichloride is key intermediates. [0003] By using triphenylphosphine oxide as a raw material, many patents have been reported for the preparation of triphenylphosphine dichloride. Patent US 3405180 has reported that triphenylphosphine oxide and phosphorus pentachloride or triphenylphosphine oxide and dichloro Sulfone reacts in solvents such as o-dichlorobenzene, generates triphenylphosphine dichloride; Patent US 3855310 reports generating triphenylphosphine dichloride with the reaction of triphenylphosphine oxide, phosphorus trichloride and chlorine; the above-mentioned three In ...

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Problems solved by technology

[0003] By using triphenylphosphine oxide as a raw material, many patents have been reported for the preparation of triphenylphosphine dichloride. Patent US 3405180 has reported that triphenylphosphine oxide and phosphorus pentachloride or triphenylphosphine oxide and dichloro Sulfone reacts in solvents such as o-dichlorobenzene, generates triphenylphosphine dichloride; Patent US 3855310 reports generating triphenylphosphine dichloride with the reaction of triphenylphosphine oxide, phosphorus trichloride and chlorine; the above-mentioned three In this method, the raw material is expensive, the yield is low, the reaction produces a lot of waste, and the environment is polluted greatly.

[0004] Patent US 4301301 adopts the method of introducing carbon monoxide and chlorine gas into a solution containing triphenylphosphine oxide to generate triphenylphosphine dichloride. The solvent used in this method needs to remove water and oxygen, and the reaction needs to be pressurized, and carbon monoxide and chlorine gas High toxicity, high transportation cost for gas at room temperature

[0005] Patents US 4249023 and US 5527966 react triphenylphosphine oxide and phosgene in different organic solvents to generate triphenylphosphine dichloride. This method uses highly toxic phosgene, which is highly dangerous, and the gas phosgene is not conducive to transportation