Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methyleneseleno propanel method for preparing selenoic methionine

A technology for selenomethionine and amino acids, which is applied in the fields of preparing selenomethionine, chemical synthesis intermediates, and treating diabetes, and can solve the problems of low yield, limited development of methionine seleno analogs, large scale of equipment, etc.

Inactive Publication Date: 2002-09-18
董国臣
View PDF1 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The existing preparation method of selenomethionine, whether it is chemical synthesis method or biosynthesis method, has complex process conditions and difficult management; low product concentration and low yield; large-scale equipment and small profit
Therefore, selenomethionine products cannot meet the supply and demand of the market, and limit the development of selenomethionine analogues

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The chemical synthesis methods for producing methionine mainly include Strecker method, malonate, aminolactone method and Heine method, most of which are used at home and abroad. Among them, the important intermediate methylselenopropanal, which is an important intermediate of the Heine method and the malonate method, uses methylselenol instead of methylmercaptan to react with acrolein to synthesize the methylselenopropionaldehyde intermediate, and realizes the chemical synthesis of selenium on the methionine production line. Methionine, that is, methylselenopropionaldehyde method to prepare selenomethionine.

[0021] Production method:

[0022] Routing:

[0023] crafting process:

[0024] 1. Dehydration: Yield 95% (in propylene) or 70% (in glycerin), batching ratio, glycerol: potassium bisulfate: potassium sulfate=1: 0.5: 0.26. Put 1 / 7 of the glycerin and all the potassium bisulfate and potassium sulfate into the reaction kettle, and start adding the rest of the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for preparing selenoic methionine by methyleneseleno propanal method includes preparing the important intermediate, methyleneseleno propanel, from methyleneselenol, acroleic acid relative compounds by chemical synthesis, and chemically synthesizing selenoic methionic from it along with se and methionine by conventional process. The resultant product has excellent more bioactivities and the insulin-like action, so it can be used for treating diabetes.

Description

(1) Technical field: [0001] The invention belongs to the field of amino acid drugs, and relates to the preparation of selenomethionine by chemical synthesis intermediate methylselenopropanal; [0002] The present invention also relates to the technique for treating diabetes by the insulin-like effect of biological trace element and amino acid complex selenomethionine. (two) background technology: [0003] As we all know, since the important biological activity of the trace element selenium exists in the form of selenium-containing amino acids in organisms, especially selenomethionine is widely used in medicine, health care, agriculture, nutrition and other departments, and the preparation method of selenomethionine has been paid attention to. [0004] 1. Existing technology: [0005] (1) Liquid ammonia method (Na / lig NH 4 ) to prepare selenomethionine: In order to obtain selenomethionine, (selenium)-benzylselenohomocysteine ​​is usually used to reductively remove the benzy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C391/00
Inventor 董国臣
Owner 董国臣
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com