Radix cyathulae fructosan, preparation process and use thereof

A technique of Achyranthes bidentata and fructan, applied in the fields of Achyranthes bidentata and fructan, its preparation and application, to achieve high yield, simple extraction and separation method, and the effect of inhibiting Lewis lung cancer

Inactive Publication Date: 2003-08-06
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the research on sugar compounds of Achyranthes bidentata

Method used

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  • Radix cyathulae fructosan, preparation process and use thereof
  • Radix cyathulae fructosan, preparation process and use thereof
  • Radix cyathulae fructosan, preparation process and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Wash and dry 100g of Rhizoma Achyranthes Radix, cut into slices, soak in 1 liter of deionized water at room temperature for 48 hours, and filter. The residue was soaked in 1 liter of deionized water for 12 hours, filtered, and the combined filtrates were concentrated under reduced pressure at 60° C., then precipitated with 5 times the volume of 95% ethanol, and the precipitate was allowed to stand for 24 hours. Centrifuge, dissolve the precipitate with 100 ml of water, centrifuge, separate with a membrane with a molecular weight cut-off of 1000, and freeze-dry to obtain 15-17 g of total polysaccharides of Achyranthes bidentata.

Embodiment 2

[0028] Wash and dry 100 g of Rhizoma Achyranthes Radix, cut into slices, soak in 1.2 liters of deionized water at room temperature for 48 hours, and filter. The residue was soaked in 1 liter of deionized water for 12 hours, filtered, and the combined filtrates were concentrated under reduced pressure at 50° C., then precipitated with 3 times the volume of 95% acetone, and the precipitate was allowed to stand for 24 hours. After centrifugation, the precipitate was dissolved with 100 ml of water, centrifuged, and dialyzed against ion-free water for 72 hours. Concentrate under reduced pressure at 50°C and freeze-dry to obtain 13-15 g of total polysaccharides of Achyranthes bidentata.

Embodiment 3

[0030] Wash and dry 100 g of Rhizoma Achyranthes Radix, cut into slices, soak in 0.8 liter of deionized water at room temperature for 48 hours, and filter. The residue was soaked in 0.5 liter of deionized water for 12 hours, filtered, and the filtrates were combined, concentrated under reduced pressure at 50°C, dialyzed in deionized water for 72 hours, and centrifuged. Concentrate under reduced pressure at 50°C and freeze-dry to obtain 15-17 g of total polysaccharides of Achyranthes bidentata.

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Abstract

The present invention relates to a production method for extracting fructosan from Chinese medicinal material radix cyathula and its application. Said method includes the following steps: soaking cyathula root in water to obtain aqueous extract of radix cyathula, using organic solvent to make preciptiation, dissolving the precipitate with water, making supernatnat fluid undergo the processes of dialysis or membrane separation, concentration and drying to obtain total polysaccharide, and making the obtained cyathula total polysaccharide undergo the process of column chromatography to make purification so as to obtain the cyathula fructosan CoPS. Said invention provides its chemical structure formula. It can be used for preparing medicine and health-care product with the actions of resisting tumor and raising immunological function.

Description

technical field [0001] The invention relates to extracting Achyranthes bidentata fructan and its total polysaccharides from traditional Chinese medicine Achyranthes bidentata, a preparation method and application. Background technique [0002] Cyathula Officinals Kuan (Cyathula Officinals Kuan) is a traditional Chinese medicinal material, which has the functions of dispelling blood stasis, dredging menstrual flow, benefiting joints, diuresis and treating stranguria. According to literature reports, [Ma Ying et al., Chinese Herbal Medicine, 31(6), 427(2000)], its chemical components are mainly alkaloids and sterones, such as calixanthone, cephalanthrone, etc. However, the research on sugar compounds of Achyranthes bidentata has not been reported yet. Contents of the invention [0003] The problem to be solved by the present invention is to provide Achyranthes bidentata fructan CoPS and its total polysaccharide, its production method and application. [0004] The present i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
Inventor 田庚元陈晓明
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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