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A technology of huperzine and preparations, which is applied in the field of compositions for transdermal administration of huperzine, and can solve problems such as frequent medication
Inactive Publication Date: 2003-10-22
美国爱科赛尔制药有限公司
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[0007] There are many ways to treat patients with memory loss and cognitive impairment, such as oral administration, but one of the difficulties is the need for frequent medication
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[0037] The term "matrix", "matrix system" or "matrix patch" as used herein refers to dissolving or suspending a certain amount of huperzine in a polymer carrier or phase. In addition, it can also promote penetration The agent or other health-beneficial substances are dissolved or suspended in the pressure-sensitive adhesive. This definition refers to the following embodiments: this type of polymer phase is laminated to a pressure-sensitive adhesive, or the adhesive is used to make an adhesive skeleton-type patch with a reservoir. This type of framework patch usually contains an adhesive layer, the outer surface of which is an impermeable backing film, and the inner surface is a release liner, which must be torn off before use. The backing film is to protect the polymer phase of the matrix patch to prevent the transfer of drugs and / or accelerators to the external environment. The release liner film functions like a backing film, but the adhesive matrix-type patch is torn off as des...
Embodiment 4
[0119] Formulation Four (1)
[0120] * A mixture of a single Eudragit and different levels of Eudragit. Eudragit can be selected from: NE30D, L100, L12 / 5, S100, S12 / 5, L30D-55, E100, E12 / 5, RL100, RL12 / 5, R100, RLPO, PLPM, RL30D, RS100, RS12 / 5, RSPM , RSPO, RS30D, etc.
[0127] Test results show that penetration enhancers can increase the rate of Huperzine A through the skin from the gel formulation. The gel preparation is suitable for topical administration or depot patch.
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Abstract
The present invention provides a composition of transdermally administered huperzine for improving memory and cognitive function. In one aspect, huperzine is delivered in a sufficient amount to achieve and maintain a blood plasma Huperzine level of about 0.1 ng / mL to about to 30 ng / mL. Huperzine may be delivered by itself, or in combination with other positive health promoting substances, such as vitamins, minerals, other cholinesterase inhibitors, etc. Various formulations for the transdermal delivery of huperzine are disclosed, and may include selected penetration enhancers.
Description
Technical field [0001] The present invention mainly relates to a composition and method capable of improving human memory and cognitive functions. More specifically, the present invention relates to a composition and method for transdermal administration of huperzine capable of achieving a desired blood concentration. Background of the invention [0002] Good memory and cognitive functions are very important for a person's self-reliance and self-care. It is an important part of a person's quality of life. Generally speaking, people with excellent memory and cognitive abilities have outstanding results, and they will also achieve outstanding results in academic and professional fields. At the same time, people with clear thinking and decisive actions tend to have good social skills. [0003] Many people benefit from good memory and cognitive abilities, and many people are eager to improve this ability. In addition, those who suffer from cognitive and memory dysfunctions are enduri...
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