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Transdermal administration of huperzine

A technology of huperzine and preparations, which is applied in the field of compositions for transdermal administration of huperzine, and can solve problems such as frequent medication

Inactive Publication Date: 2003-10-22
美国爱科赛尔制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many ways to treat patients with memory loss and cognitive impairment, such as oral administration, but one of the difficulties is the need for frequent medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0037] The term "matrix", "matrix system" or "matrix patch" as used herein refers to dissolving or suspending a certain amount of huperzine in a polymer carrier or phase. In addition, it can also promote penetration The agent or other health-beneficial substances are dissolved or suspended in the pressure-sensitive adhesive. This definition refers to the following embodiments: this type of polymer phase is laminated to a pressure-sensitive adhesive, or the adhesive is used to make an adhesive skeleton-type patch with a reservoir. This type of framework patch usually contains an adhesive layer, the outer surface of which is an impermeable backing film, and the inner surface is a release liner, which must be torn off before use. The backing film is to protect the polymer phase of the matrix patch to prevent the transfer of drugs and / or accelerators to the external environment. The release liner film functions like a backing film, but the adhesive matrix-type patch is torn off as des...

Embodiment 4

[0119] Formulation Four (1)

[0120] * A mixture of a single Eudragit and different levels of Eudragit. Eudragit can be selected from: NE30D, L100, L12 / 5, S100, S12 / 5, L30D-55, E100, E12 / 5, RL100, RL12 / 5, R100, RLPO, PLPM, RL30D, RS100, RS12 / 5, RSPM , RSPO, RS30D, etc.

Embodiment 5

[0123] GMO: Glycerol Monooleate

[0124] LA: Lauryl Alcohol

[0125] L-DEA: Lauromide DEA (Lauromide DEA)

[0126] * (mean±SD), n=3 skin donors, 12 diffusion grooves

[0127] Test results show that penetration enhancers can increase the rate of Huperzine A through the skin from the gel formulation. The gel preparation is suitable for topical administration or depot patch.

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Abstract

The present invention provides a composition of transdermally administered huperzine for improving memory and cognitive function. In one aspect, huperzine is delivered in a sufficient amount to achieve and maintain a blood plasma Huperzine level of about 0.1 ng / mL to about to 30 ng / mL. Huperzine may be delivered by itself, or in combination with other positive health promoting substances, such as vitamins, minerals, other cholinesterase inhibitors, etc. Various formulations for the transdermal delivery of huperzine are disclosed, and may include selected penetration enhancers.

Description

Technical field [0001] The present invention mainly relates to a composition and method capable of improving human memory and cognitive functions. More specifically, the present invention relates to a composition and method for transdermal administration of huperzine capable of achieving a desired blood concentration. Background of the invention [0002] Good memory and cognitive functions are very important for a person's self-reliance and self-care. It is an important part of a person's quality of life. Generally speaking, people with excellent memory and cognitive abilities have outstanding results, and they will also achieve outstanding results in academic and professional fields. At the same time, people with clear thinking and decisive actions tend to have good social skills. [0003] Many people benefit from good memory and cognitive abilities, and many people are eager to improve this ability. In addition, those who suffer from cognitive and memory dysfunctions are enduri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/44A61K31/4748A61K45/06A61K47/06A61K47/10A61K47/14A61K47/18A61K47/26
CPCA61K31/4748A61K47/06A61K9/7069A61K9/7053A61K9/7061A61K47/26A61K9/0014A61K47/14A61K47/10A61K47/18A61K31/44A61K45/06A61P25/00A61K31/00A61K2300/00
Inventor 熊伟弘狄奈希·C·帕泰尔
Owner 美国爱科赛尔制药有限公司
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